Dokument: BCG Vaccination-Associated Lower HbA1c and Increased CD25 Expression on CD8+ T Cells in Patients with Type 1 Diabetes in Ghana
| Titel: | BCG Vaccination-Associated Lower HbA1c and Increased CD25 Expression on CD8+ T Cells in Patients with Type 1 Diabetes in Ghana | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68434 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250204-121701-7 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Aniagyei, Wilfred [Autor] Mohayideen, Sumaya [Autor] Sarfo-Kantanka, Osei [Autor] Bittner, Sarah [Autor] Vivekanandan, Monika M. [Autor] Arthur, Joseph F. [Autor] Boateng, Agnes O. [Autor] Yeboah, Augustine [Autor] Ahor, Hubert Senanu [Autor] Asibey, Shadrack O. [Autor] | |||||||
| Dateien: |
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| Stichwörter: | BCG vaccination, glycolysis, type 1 diabetes, immunomodulation, T cells | |||||||
| Beschreibung: | BCG vaccination affects other diseases beyond tuberculosis by unknown—potentially immunomodulatory—mechanisms. Recent studies have shown that BCG vaccination administered during overt type 1 diabetes (T1D) improved glycemic control and affected immune and metabolic parameters. Here, we comprehensively characterized Ghanaian T1D patients with or without routine neonatal BCG vaccination to identify vaccine-associated alterations. Ghanaian long-term T1D patients (n = 108) and matched healthy controls (n = 214) were evaluated for disease-related clinical, metabolic, and immunophenotypic parameters and compared based on their neonatal BCG vaccination status. The majority of study participants were BCG-vaccinated at birth and no differences in vaccination rates were detected between the study groups. Notably, glycemic control metrics, i.e., HbA1c and IDAA1c, showed significantly lower levels in BCG-vaccinated as compared to unvaccinated patients. Immunophenotype comparisons identified higher expression of the T cell activation marker CD25 on CD8+ T cells from BCG-vaccinated T1D patients. Correlation analysis identified a negative correlation between HbA1c levels and CD25 expression on CD8+ T cells. In addition, we observed fractional increases in glycolysis metabolites (phosphoenolpyruvate and 2/3-phosphoglycerate) in BCG-vaccinated T1D patients. These results suggest that neonatal BCG vaccination is associated with better glycemic control and increased activation of CD8+ T cells in T1D patients. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Aniagyei, W., Mohayideen, S., Sarfo-Kantanka, O., Bittner, S., Vivekanandan, M. M., Arthur, J. F., Boateng, A. O., Yeboah, A., Ahor, H. S., Asibey, S. O., Owusu, E., Herebian, D., Huttasch, M., Burkart, V., Wagner, R., Roden, M., Adankwah, E., Owusu, D. O., Mayatepek, E., … Seyfarth, J. (2024). BCG Vaccination-Associated Lower HbA1c and Increased CD25 Expression on CD8+ T Cells in Patients with Type 1 Diabetes in Ghana. Vaccines, 12(5), Article 452. https://doi.org/10.3390/vaccines12050452 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 04.02.2025 | |||||||
| Dateien geändert am: | 04.02.2025 |
