Dokument: Associating Appendicitis with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Novel Insight into an Unexpected Connection
| Titel: | Associating Appendicitis with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Novel Insight into an Unexpected Connection | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68425 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250204-093338-1 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Roderburg, Christoph [Autor] Waldschmidt, Dirk [Autor] Leyh, Catherine [Autor] Krieg, Sarah [Autor] Krieg, Andreas [Autor] Luedde, Tom [Autor] Loosen, Sven H. [Autor] Kostev, Karel [Autor] | |||||||
| Dateien: |
| |||||||
| Stichwörter: | NAFLD, metALD, epidemiology, MASH, MASLD, appendicitis | |||||||
| Beschreibung: | Background:
The gut microbiome modulates the liver immune microenvironment and is deeply integrated into the pathophysiology of metabolic dysfunction-associated steatotic liver disease (MASLD). Appendectomies, which are performed in almost all patients diagnosed with appendicitis, cause long-term alterations to the gut microbiome, providing a potential link with the development of MASLD. We therefore investigated a potential link between appendicitis and the presence of MASLD in a large cohort of outpatients in Germany. Methods: The present study included 26,717 individuals with and 26,717 without appendicitis. Univariable Cox-regression analyses were conducted to assess the association between appendicitis and MASLD. Results: During the long-term follow-up, 4.8% of patients with appendicitis and 3.4% of those in the non-appendicitis group were diagnosed with MASLD (p < 0.001), corresponding to an incidence of 5.4 (appendicitis cohort) versus 3.5 (non-appendicitis cohort) cases per 1000 patient years. These findings were confirmed in regression analysis, revealing a strong and statistically significant association between appendicitis and the development of MASLD (HR: 1.57; 95% CI: 1.39–1.78). This link was observed for all age groups and was independent of patients’ sex. Conclusion: We provide evidence from a large cohort of outpatients in Germany suggesting a link between appendicitis and MASLD. This might help to better stratify patients according to their individual risk for the development of chronic liver diseases. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Roderburg, C., Waldschmidt, D., Leyh, C., Krieg, S., Krieg, A., Lüdde, T., Loosen, S. H., & Kostev, K. (2024). Associating Appendicitis with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Novel Insight into an Unexpected Connection. Journal of Clinical Medicine, 13(5), Article 1319. https://doi.org/10.3390/jcm13051319 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 04.02.2025 | |||||||
| Dateien geändert am: | 04.02.2025 |
