Dokument: Association between early postoperative hypoalbuminaemia and outcome after orthotopic heart transplantation
| Titel: | Association between early postoperative hypoalbuminaemia and outcome after orthotopic heart transplantation | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68399 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250203-092255-9 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | M'Pembele, René [Autor] Roth, Sebastian [Autor] Jenkins, Freya Sophie [Autor] Hettlich, Vincent [Autor] Nucaro, Anthony [Autor] Stroda, Alexandra [Autor] Tenge, Theresa [Autor] Polzin, Amin [Autor] Ramadani, Bedri [Autor] Lurati Buse, Giovanna [Autor] | |||||||
| Dateien: |
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| Stichwörter: | biomarkers, prognosis, risk stratification, cardiac surgery, liver function | |||||||
| Beschreibung: | OBJECTIVES:
In patients undergoing heart transplantation (HTX), preoperative liver impairment and consecutive hypoalbuminaemia are associated with increased mortality. The role of early postoperative hypoalbuminaemia after HTX is unclear. This study investigated the association between early postoperative hypoalbuminaemia and 1-year mortality as well as ‘days alive and out of hospital’ (DAOH) after HTX. METHODS: This retrospective cohort study included patients who underwent HTX at the University Hospital Duesseldorf, Germany, between 2010 and 2022. The main exposure was serum albumin concentration at intensive care unit (ICU) arrival. The primary endpoints were mortality and DAOH within 1 year after surgery. Receiver operating characteristic (ROC) curve analysis was performed and logistic and quantile regression models with adjustment for 13 a priori defined clinical risk factors were conducted. RESULTS: Out of 241 patients screened, 229 were included in the analysis (mean age 55±11years, 73% male). ROC analysis showed moderate discrimination for 1-year mortality by postoperative serum albumin after HTX [AUC¼0.74; 95% confidence interval (CI): 0.66– 0.83]. The cutoff for serum albumin at ICU arrival was 3.0g/dl. According to multivariate logistic and quantile regression, there were independent associations between hypoalbuminaemia and mortality/DAOH [odds ratio of 4.76 (95% CI: 1.94–11.67) and regression coefficient of −46.97 (95% CI: −83.81 to −10.13)]. CONCLUSIONS: Postoperative hypoalbuminaemia <3.0g/dl is associated with 1-year mortality and reduced DAOH after HTX and therefore might be used for early postoperative risk re-assessment in clinical practice. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
M’Pembele, R., Roth, S., Jenkins, F. S., Hettlich, V., Nucaro, A., Stroda, A., Tenge, T., Polzin, A., Ramadani, B., Lurati Buse, G., Aubin, H., Lichtenberg , A., Huhn, R., & Boeken, U. (2024). Association between early postoperative hypoalbuminaemia and outcome after orthotopic heart transplantation. Interdisciplinary CardioVascular and Thoracic Surgery, 38(1), Article ivae012. https://doi.org/10.1093/icvts/ivae012 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 03.02.2025 | |||||||
| Dateien geändert am: | 03.02.2025 |
