Dokument: Croscarmellose Sodium as Pelletization Aid in Extrusion-Spheronization
| Titel: | Croscarmellose Sodium as Pelletization Aid in Extrusion-Spheronization | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68233 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20250123-125522-4 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Siebel, Finn [Autor] Kleinebudde, Peter [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Extrusion-spheronization, Croscarmellose sodium, Pelletization aid, Multivalent cations | |||||||
| Beschreibung: | Only few excipients are known to be suitable as pelletization aids. In this study, the potential use of croscarmellose sodium (CCS) as pelletization aid was investigated. Furthermore, the impact of cations on extrusion-spheronization (ES) of CCS was studied and different grades of CCS were tested. The influence of different cations on the swelling of CCS was investigated by laser diffraction. Mixtures of CCS with lactose monohydrate as filler with or without the inclusion of different cations were produced. The mixtures were investigated by mixer torque rheometry and consequently extruded and spheronized. Resulting pellets were analyzed by dynamic image analysis. In addition, mixtures of different CCS grades with dibasic calcium phosphate anhydrous (DP) and a mixture with praziquantel (PZQ) as filler were investigated. Calcium and magnesium cations caused a decrease of the swelling of CCS and influenced the use of CCS as pelletization aid since they needed to be included for successful ES. Aluminum, however, led to an aggregation of the CCS particles and to failure of extrusion. The inclusion of cations decreased the uptake of water by the mixtures which also reduced the liquid-to-solid-ratio (L/S) for successful ES. This was shown to be dependent on the amount of divalent cations in the mixture. With DP or PZQ as filler, no addition of cations was necessary for a successful production of pellets, however the optimal L/S for ES was dependent on the CCS grade used. In conclusion, CCS can be used as a pelletization aid. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Siebel, F., & Kleinebudde, P. (2024). Croscarmellose Sodium as Pelletization Aid in Extrusion-Spheronization. AAPS PharmSciTech, 25(6), Article 147. https://doi.org/10.1208/s12249-024-02864-0 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 23.01.2025 | |||||||
| Dateien geändert am: | 23.01.2025 |
