Dokument: Identification of myeloid-derived growth factor as a mechanically-induced, growth-promoting angiocrine signal for human hepatocytes
| Titel: | Identification of myeloid-derived growth factor as a mechanically-induced, growth-promoting angiocrine signal for human hepatocytes | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=68007 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241219-114935-3 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Große-Segerath, Linda [Autor] Follert, Paula [Autor] Behnke, Kristina [Autor] Ettich, Julia [Autor] Buschmann, Tobias [Autor] Kirschner, Philip [Autor] Hartwig, Sonja [Autor] Lehr, Stefan [Autor] Korf-Klingebiel, Mortimer [Autor] Eberhard, Daniel [Autor] | |||||||
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| Beschreibung: | Recently, we have shown that after partial hepatectomy (PHx), an increased hepatic blood flow initiates liver growth in mice by vasodilation and mechanically-triggered release of angiocrine signals. Here, we use mass spectrometry to identify a mechanically-induced angiocrine signal in human hepatic endothelial cells, that is, myeloid-derived growth factor (MYDGF). We show that it induces proliferation and promotes survival of primary human hepatocytes derived from different donors in two-dimensional cell culture, via activation of mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription 3 (STAT3). MYDGF also enhances proliferation of human hepatocytes in three-dimensional organoids. In vivo, genetic deletion of MYDGF decreases hepatocyte proliferation in the regenerating mouse liver after PHx; conversely, adeno-associated viral delivery of MYDGF increases hepatocyte proliferation and MAPK signaling after PHx. We conclude that MYDGF represents a mechanically-induced angiocrine signal and that it triggers growth of, and provides protection to, primary mouse and human hepatocytes. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Große-Segerath, L., Follert, P., Behnke, K., Ettich, J., Buschmann, T., Kirschner, P., Hartwig, S., Lehr, S., Korf-Klingebiel, M., Eberhard, D., Lehwald-Tywuschik, N., Al-Hasani, H., Knoefel, W. T., Heinrich, S., Levkau, B., Wollert, K. C., Scheller, J., & Lammert, E. (2024). Identification of myeloid-derived growth factor as a mechanically-induced, growth-promoting angiocrine signal for human hepatocytes. Nature Communications, 15, Article 1076. https://doi.org/10.1038/s41467-024-44760-y [https://doi.org/10.1038/s41467-024-44760-y] | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät Medizinische Fakultät | |||||||
| Dokument erstellt am: | 19.12.2024 | |||||||
| Dateien geändert am: | 19.12.2024 |
