Dokument: Differences in PPD- and mitogen-induced T-cell activation marker expression characterize immunopathology in acute tuberculosis patients
| Titel: | Differences in PPD- and mitogen-induced T-cell activation marker expression characterize immunopathology in acute tuberculosis patients | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67996 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241218-133006-7 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Acheampong, Isaac [Autor] Minadzi, Difery [Autor] Laing, Edwin F. [Autor] Frimpong, Michael [Autor] Vivekanandan, Monika M. [Autor] Yeboah, Augustine [Autor] Adankwah, Ernest [Autor] Aniagyei, Wilfred [Autor] Arthur, Joseph F. [Autor] Lamptey, Milicent [Autor] | |||||||
| Dateien: |
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| Stichwörter: | T-cell activation marker, Tuberculosis, Anergy, Mitogen, Immunopathology | |||||||
| Beschreibung: | Impaired T-cell responses to mitogens and high T-cell activation marker (TAM) expression on Mycobacterium tuberculosis–specific T-cells characterize immunopathology in patients with tuberculosis (TB). In a study of patients with TB (n = 60) and asymptomatic contacts (controls, n = 37), we found that TB patients had higher CD38+ T-cell proportions specific for M. tuberculosis protein (PPDMtb), yet total proportions of PPDMtb-specific T-cells were comparable. Notably, both activated (CD38+) and total IFN-γ+ T-cells from TB patients had lower mitogen (phytohemagglutinin, PHA)-induced responses. This impaired mitogen response improved the classification efficacy of the TAM-TB assay, especially employing the PPD/PHA-induced T-cell ratio. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Acheampong, I., Minadzi, D., Laing, E. F., Frimpong, M., Vivekanandan, M. M., Yeboah, A., Adankwah, E., Aniagyei, W., Arthur, J. F., Lamptey, M., Abass, M. K., Kumbel, F., Osei-Yeboah, F., Gawusu, A., Debrah, L. B., Owusu, D. O., Debrah, A., Mayatepek, E., Seyfarth, J., … Jacobsen, M. (2024). Differences in PPD- and mitogen-induced T-cell activation marker expression characterize immunopathology in acute tuberculosis patients. European Journal of Clinical Microbiology & Infectious Diseases, 43(3), 611–616. https://doi.org/10.1007/s10096-023-04741-3 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 18.12.2024 | |||||||
| Dateien geändert am: | 18.12.2024 |
