Dokument: Central intra-lesional iron deposits as a possible novel imaging marker at 7 Tesla MRI in Susac Syndrome - an exploratory study
| Titel: | Central intra-lesional iron deposits as a possible novel imaging marker at 7 Tesla MRI in Susac Syndrome - an exploratory study | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67992 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241218-121355-9 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Strunk, Daniel [Autor] Sinnecker, Tim [Autor] Kleffner, Ilka [Autor] Doerr, Jan [Autor] Ringelstein, Marius [Autor] Gross, Catharina C. [Autor] Deuschl, Cornelius [Autor] Maderwald, Stefan [Autor] Quick, Harald H. [Autor] Yamac, Elif [Autor] | |||||||
| Dateien: |
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| Stichwörter: | T1 hypointense lesions, “Iron dot” lesions, Imaging marker, Susac syndrome, Central vein sign, 7 Tesla MRI | |||||||
| Beschreibung: | Background
Susac syndrome (SuS) is a rare autoimmune disease that leads to hearing impairment, visual field deficits, and encephalopathy due to an occlusion of precapillary arterioles in the brain, retina, and inner ear. Given the potentially disastrous outcome and difficulties in distinguishing SuS from its differential diagnoses, such as multiple sclerosis (MS), our exploratory study aimed at identifying potential new SuS-specific neuroimaging markers. Methods Seven patients with a definite diagnosis of SuS underwent magnetic resonance imaging (MRI) at 7 Tesla (7T), including T2* weighted and quantitative susceptibility mapping (QSM) sequences. T2 weighted hyperintense lesions were analyzed with regard to number, volume, localization, central vein sign, T1 hypointensity, and focal iron deposits in the center of SuS lesions (“iron dots”). Seven T MRI datasets from the same institute, comprising 75 patients with, among others, MS, served as controls. Results The “iron dot” sign was present in 71.4% (5/7) of the SuS patients, compared to 0% in our control cohort. Thus, sensitivity was 71.4% and specificity 100%. A central vein sign was only incidentally detected. Conclusion We are the first to demonstrate this type of “iron dot” lesions on highly resolving 7T T2*w and QSM images in vivo as a promising neuroimaging marker of SuS, corroborating previous histopathological ex vivo findings. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Strunk, D., Sinnecker, T., Kleffner, I., Doerr, J., Ringelstein, M., Gross, C. C., Deuschl, C., Maderwald, S., Quick, H. H., Yamac, E., Wrede, K. H., & Krämer, M. (2024). Central intra-lesional iron deposits as a possible novel imaging marker at 7 Tesla MRI in Susac Syndrome - an exploratory study. BMC Medical Imaging, 24, Article 4. https://doi.org/10.1186/s12880-023-01171-7 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 18.12.2024 | |||||||
| Dateien geändert am: | 18.12.2024 |
