Dokument: Acute Variceal Hemorrhage in Germany–A Nationwide Study of 65,357 Hospitalized Cases
| Titel: | Acute Variceal Hemorrhage in Germany–A Nationwide Study of 65,357 Hospitalized Cases | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67991 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241218-114559-7 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Mertens, Alexander [Autor] Essing, Tobias [Autor] Kunstein, Anselm [Autor] Weigel, Christian [Autor] Bode, Johannes [Autor] Roderburg, Christoph [Autor] Luedde, Tom [Autor] Kandler, Jennis [Autor] | |||||||
| Dateien: |
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| Stichwörter: | endoscopic therapy, TIPS, EVL, AVH, incidence, EST, variceal bleeding, adverse event, outcome, in-hospital mortality | |||||||
| Beschreibung: | Background:
Acute variceal hemorrhage (AVH) is a frequent cause of upper gastrointestinal bleeding (UGIB) in liver cirrhosis. Most cases require urgent endoscopic intervention due to potentially life-threatening courses. Di9erent endoscopic hemostasis techniques can be used, in particular endoscopic variceal ligation (EVL) and endoscopic sclerotherapy (EST), depending on the bleeding side (esophageal, fundal, and gastric) as well as radiological interventions (e.g., embolization and transjugular intrahepatic portosystemic shunt [TIPS]). *is study aimed to investigate trends in incidence, treatment modalities, and outcome parameters, such as in-hospital mortality and adverse events in Germany. Methods: We evaluated the current epidemiological trends, therapeutic strategies, and in-hospital mortality of AVH in Germany based on the standardized hospital discharge data provided by the German Federal Statistical OCce from 2010 to 2019. Results: A total of 65,357 AVH cases, predominately males (68.3%), were included in the analysis. *e annual incidence rate (hospitalization cases per 100,000 persons) was 8.9. *e in-hospital mortality was 18.6%. *e most common underlying disease was alcoholrelated liver cirrhosis (60.6%).*emost common clinical complication was bleeding anemia (60.1%), whereas hypovolemic shock (12.8%) was the less frequent. In esophageal variceal hemorrhage (EVH), EVL was the most frequently performed endoscopic therapy, while in gastric variceal hemorrhage (GVH), ESTand Ibrin glue injection were the most commonly performed therapies. EVL showed the lowest in-hospital mortality (12.3%) in EVH, while EST showed favorable results (14% in-hospital mortality) in GVH. Combination therapies overall showed a higher in-hospital mortality and were more frequent in GVH. *e presence of hypovolemic shock, AKI, sepsis, artiIcial ventilation, ARDS, bleeding anemia, hepatic encephalopathy, and male sex was associated with a signiIcantly worse outcome. Conclusion: Our study provides detailed insight into the incidence, patient-related risk factors, endoscopic treatment, and inhospital mortality in a sizeable AVH collective in Germany. *ese data might help improve risk stratiIcation and treatment strategies for AVH patients in the future. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Mertens, A., Essing, T., Kunstein, A., Weigel, C., Bode, J. G., Roderburg, C., Lüdde, T., Kandler, J., & Loosen, S. H. (2024). Acute Variceal Hemorrhage in Germany–A Nationwide Study of 65,357 Hospitalized Cases: Variceal Hemorrhage in Germany. Canadian Journal of Gastroenterology and Hepatology, 2024(1), Article 5453294. https://doi.org/10.1155/2024/5453294 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 18.12.2024 | |||||||
| Dateien geändert am: | 18.12.2024 |
