Dokument: Direct targeting of host microtubule and actin cytoskeletons by a chlamydial pathogenic effector protein
| Titel: | Direct targeting of host microtubule and actin cytoskeletons by a chlamydial pathogenic effector protein | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67982 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241216-105805-0 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Höhler, Mona [Autor] Alcázar-Román, Abel R. [Autor] Schenk, Katharina [Autor] Aguirre-Huamaní, Mac Pholo [Autor] Braun, Corinna [Autor] Zrieq, Rafat [Autor] Mölleken, Katja [Autor] Hegemann, Johannes H. [Autor] Fleig, Ursula [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Pathogenic bacteria, Cytoskeleton, Microtubules, Chlamydia | |||||||
| Beschreibung: | To propagate within a eukaryotic cell, pathogenic bacteria hijack and remodulate host cell functions. The Gram-negative obligate intracellular Chlamydiaceae, which pose a serious threat to human and animal health, attach to host cells and inject effector proteins that reprogram host cell machineries. Members of the conserved chlamydial TarP family have been characterized as major early effectors that bind to and remodel the host actin cytoskeleton. We now describe a new function for the Chlamydia pneumoniae TarP member CPn0572, namely the ability to bind and alter the microtubule cytoskeleton. Thus, CPn0572 is unique in being the only prokaryotic protein that directly modulates both dynamic cytoskeletons of a eukaryotic cell. Ectopically expressed GFP–CPn0572 associates in a dose-independent manner with either cytoskeleton singly or simultaneously. In vitro, CPn0572 binds directly to microtubules. Expression of a microtubule-only CPn0572 variant resulted in the formation of an aberrantly thick, stabilized microtubule network. Intriguingly, during infection, secreted CPn0572 also colocalized with altered microtubules, suggesting that this protein also affects microtubule dynamics during infection. Our analysis points to a crosstalk between actin and microtubule cytoskeletons via chlamydial CPn0572 | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Höhler, M., Alcázar-Román, A. R., Schenk, K., Aguirre-Huamaní, M. P., Braun, C. U., Zrieq, R., Mölleken, K., Hegemann, J. H., & Fleig, U.-N. (2024). Direct targeting of host microtubule and actin cytoskeletons by a chlamydial pathogenic effector protein. Journal of Cell Science, 137(17), Article jcs263450. https://doi.org/10.1242/jcs.263450 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 16.12.2024 | |||||||
| Dateien geändert am: | 16.12.2024 |
