Dokument: Dynamics of intracellular and intercellular redox communication
| Titel: | Dynamics of intracellular and intercellular redox communication | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67942 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241210-115939-0 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autor: | Sies, Helmut [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Compartmentation, Redox code, Redox heterogeneity, Oxidative stress, Redox regulation, Hydrogen peroxide, Redoxosomes, Exosomes, Membraneless organelles, Extracellular vesicles | |||||||
| Beschreibung: | Cell and organ metabolism is organized through various signaling mechanisms, including redox, Ca2+, kinase and electrochemical pathways. Redox signaling operates at multiple levels, from interactions between individual molecules in their microenvironment to communication among subcellular organelles, single cells, organs, and the entire organism. Redox communication is a dynamic and ongoing spatiotemporal process. This article focuses on hydrogen peroxide (H2O2), a key second messenger that targets redox-active protein cysteine thiolates. H2O2 gradients across cell membranes are controlled by peroxiporins, specialized aquaporins. Redox-active endosomes, known as redoxosomes, form at the plasma membrane. Cell-to-cell redox communication involves direct contacts, such as per gap junctions that connect cells for transfer of molecules via connexons. Moreover, signaling occurs through the release of redox-active molecules and enzymes into the surrounding space, as well as through various types of extracellular vesicles (EVs) that transport these signals to nearby or distant target cells. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Sies, H. (2024). Dynamics of intracellular and intercellular redox communication. Free Radical Biology & Medicine, 225, 933–939. https://doi.org/10.1016/j.freeradbiomed.2024.11.002 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 10.12.2024 | |||||||
| Dateien geändert am: | 10.12.2024 |
