Dokument: Concomitant parasite infections influence tuberculosis immunopathology and favor rapid sputum conversion of pulmonary tuberculosis patients
| Titel: | Concomitant parasite infections influence tuberculosis immunopathology and favor rapid sputum conversion of pulmonary tuberculosis patients | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67935 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241210-092516-0 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Yeboah, Augustine [Autor] Vivekanandan, Monika M. [Autor] Adankwah, Ernest [Autor] Owusu, Dorcas O. [Autor] Aniagyei, Wilfred [Autor] Minadzi, Difery [Autor] Acheampong, Isaac [Autor] Arthur, Joseph F. [Autor] Lamptey, Milicent [Autor] Abass, Mohammed K. [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Tuberculosis, Treatment efficacy, Co-infections, IL-6 | |||||||
| Beschreibung: | Immunopathology of human tuberculosis (TB) in a subgroup of patients is characterized by aberrantly high concentrations of inflammatory cytokines, for example Interleukin (IL)-6. Concomitant (co-)infections by parasites can affect host immunity, but the impact on immunopathology in TB patients is poorly defined. Here we characterized a group of patients with TB ( n = 76) from Ghana with different protozoan and helminth co-infections. Plasma cytokines were measured at the onset of disease and anti-mycobacterial treatment efficacy was monitored during disease course. A subgroup of TB patients had co-infections with protozoan (n = 19) or helminth (n = 16) parasites. Plasma analyses for candidate cytokines identified lower levels of IL-6 in parasite co-infected patients with TB. Moreover, it took less time for co-infected patients to become sputum-negative for Mycobacterium tuberculosis during treatment. These results indicated an influence of parasite co-infections on immunopathology in TB and suggested positive effects on treatment efficacy. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Yeboah, A., Vivekanandan, M., Adankwah, E., Owusu, D. O., Aniagyei, W., Minadzi, D., Acheampong, I., Arthur, J. F., Lamptey, M., Abass, M. K., Kumbel, F., Osei-Yeboah, F., Gawusu, A., Debrah, L. B., Debrah, A., Mayatepek, E., Seyfarth, J., Phillips, R. O., & Jacobsen, M. (2024). Concomitant parasite infections influence tuberculosis immunopathology and favor rapid sputum conversion of pulmonary tuberculosis patients. Annals of Clinical Microbiology and Antimicrobials, 23, Article 97. https://doi.org/10.1186/s12941-024-00756-6 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 10.12.2024 | |||||||
| Dateien geändert am: | 10.12.2024 |
