Dokument: Predictive factors of 90-day mortality after curative hepatic resection for hepatocellular carcinoma: a western single-center observational study
| Titel: | Predictive factors of 90-day mortality after curative hepatic resection for hepatocellular carcinoma: a western single-center observational study | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67818 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241202-101937-4 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Vaghiri, Sascha [Autor] Lehwald-Tywuschik, Nadja [Autor] Prassas, Dimitrios [Autor] Safi, Sami-Alexander [Autor] Kalmuk, Sinan [Autor] Knoefel, Wolfram Trudo [Autor] Dizdar, Levent [Autor] Alexander, Andrea [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Predictive factors, 90-day mortality, Curative resection, Hepatocellular carcinoma | |||||||
| Beschreibung: | Purpose
The aim of this study was to identify predictive risk factors associated with 90-day mortality after hepatic resection (HR) in hepatocellular carcinoma (HCC). Methods All patients undergoing elective resection for HCC from a single- institutional and prospectively maintained database were included. Multivariate regression analysis was conducted to identify pre- and intraoperative as well as histopathological predictive factors of 90-day mortality after elective HR. Results Between August 2004 and October 2021, 196 patients were enrolled (148 male /48 female). The median age of the study cohort was 68.5 years (range19-84 years). The rate of major hepatectomy (≥ 3 segments) was 43.88%. Multivariate analysis revealed patient age ≥ 70 years [HR 2.798; (95% CI 1.263–6.198); p = 0.011], preoperative chronic renal insufficiency [HR 3.673; (95% CI 1.598–8.443); p = 0.002], Child–Pugh Score [HR 2.240; (95% CI 1.188–4.224); p = 0.013], V-Stage [HR 2.420; (95% CI 1.187–4.936); p = 0.015], and resected segments ≥ 3 [HR 4.700; (95% 1.926–11.467); p = 0.001] as the major significant determinants of the 90-day mortality. Conclusion Advanced patient age, pre-existing chronic renal insufficiency, Child–Pugh Score, extended hepatic resection, and vascular tumor involvement were identified as significant predictive factors of 90-day mortality. Proper patient selection and adjustment of treatment strategies could potentially reduce short-term mortality. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Vaghiri, S., Lehwald-Tywuschik, N., Prassas, D., Safi, S.-A., Kalmuk, S., Knoefel, W. T., Dizdar, L., & Alexander, A. (2024). Predictive factors of 90-day mortality after curative hepatic resection for hepatocellular carcinoma: a western single-center observational study. Langenbeck’s Archives of Surgery, 409(1), Article 149. https://doi.org/10.1007/s00423-024-03337-5 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 02.12.2024 | |||||||
| Dateien geändert am: | 02.12.2024 |
