Dokument: Which factors predict tumor recurrence and survival after curative hepatectomy in hepatocellular carcinoma? Results from a European institution
| Titel: | Which factors predict tumor recurrence and survival after curative hepatectomy in hepatocellular carcinoma? Results from a European institution | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67778 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241129-120707-6 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Vaghiri, Sascha [Autor] Prassas, Dimitrios [Autor] Mustafov, Onur [Autor] Kalmuk, Sinan [Autor] Knoefel, Wolfram Trudo [Autor] Lehwald-Tywuschik, Nadja [Autor] Alexander, Andrea [Autor] Dizdar, Levent [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Overall and disease free survival, Predictive factors, Curative resection, Hepatocellular carcinoma | |||||||
| Beschreibung: | Background
High tumor recurrence and dismal survival rates after curative intended resection for hepatocellular carcinoma (HCC) are still concerning. The primary goal was to assess predictive factors associated with disease-free (DFS) and overall survival (OS) in a subset of patients with HCC undergoing hepatic resection (HR). Methods Between 08/2004–7/2021, HR for HCC was performed in 188 patients at our institution. Data allocation was conducted from a prospectively maintained database. The prognostic impact of clinico-pathological factors on DFS and OS was assessed by using uni- and multivariate Cox regression analyses. Survival curves were generated with the Kaplan Meier method. Results The postoperative 1-, 3- and 5- year overall DFS and OS rates were 77.9%, 49.7%, 41% and 72.7%, 54.7%, 38.8%, respectively. Tumor diameter ≥ 45 mm [HR 1.725; (95% CI 1.091–2.727); p = 0.020], intra-abdominal abscess [HR 3.812; (95% CI 1.859–7.815); p < 0.0001], and preoperative chronic alcohol abuse [HR 1.831; (95% CI 1.102–3.042); p = 0.020] were independently predictive for DFS while diabetes mellitus [HR 1.714; (95% CI 1.147–2.561); p = 0.009), M-Stage [HR 2.656; (95% CI 1.034–6.826); p = 0.042], V-Stage [HR 1.946; (95% CI 1.299–2.915); p = 0.001, Sepsis [HR 10.999; (95% CI 5.167–23.412); p < 0.0001], and ISGLS B/C [HR 2.008; (95% CI 1.273–3.168); p = 0.003] were significant determinants of OS. Conclusions Despite high postoperative recurrence rates, an acceptable long-term survival in patients after curative HR could be achieved. The Identification of parameters related to OS and DFS improves patient-centered treatment and surveillance strategies. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Vaghiri, S., Prassas, D., Mustafov, O., Kalmuk, S., Knoefel, W. T., Lehwald-Tywuschik, N., Alexander, A., & Dizdar, L. (2024). Which factors predict tumor recurrence and survival after curative hepatectomy in hepatocellular carcinoma? Results from a European institution. BMC Surgery, 24, Article 101. https://doi.org/10.1186/s12893-024-02399-y | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 29.11.2024 | |||||||
| Dateien geändert am: | 29.11.2024 |
