Dokument: Tobacco smoke condensate-induced senescence in endothelial cells was ameliorated by colchicine treatment via suppression of NF-κB and MAPKs P38 and ERK pathways activation
| Titel: | Tobacco smoke condensate-induced senescence in endothelial cells was ameliorated by colchicine treatment via suppression of NF-κB and MAPKs P38 and ERK pathways activation | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67775 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241129-113024-2 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Khan, Dilaware [Autor] Zhou, Huakang [Autor] You, Jinliang [Autor] Kaiser, Vera Annika [Autor] Khajuria, Rajiv Kumar [Autor] Muhammad, Sajjad [Autor] | |||||||
| Dateien: |
| |||||||
| Stichwörter: | MAPKs, HUVECs, Tobacco smoke, NF-kB, Senescence, SASP factors | |||||||
| Beschreibung: | Smoking is the major cause of cardiovascular diseases and cancer. It induces oxidative stress, leading to DNA damage and cellular senescence. Senescent cells increase the expression and release of pro-inflammatory molecules and matrix metalloproteinase, which are known to play a vital role in the initiation and progression of cardiovascular diseases and metastasis in cancer. The current study investigated the smoking induced cellular senescence and employed colchicine that blocked senescence in endothelial cells exposed to tobacco smoke condensate. Colchicine prevented oxidative stress and DNA damage in tobacco smoke-condensate-treated endothelial cells. Colchicin reduced β-gal activity, improved Lamin B1, and attenuated cell growth arrest markers P21 and P53. Colchicine also ameliorated the expression of SASP factors and inhibited the activation of NF-kB and MAPKs P38 and ERK. In summary, colchicine inhibited tobacco smoke condensate-induced senescence in endothelial cells by blocking the activation of NF-kB and MAPKs P38 and ERK. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Khan, D., Zhou, H., You, J., Kaiser, V. A., Khajuria, R. K., & Muhammad, S. (2024). Tobacco smoke condensate-induced senescence in endothelial cells was ameliorated by colchicine treatment via suppression of NF-κB and MAPKs P38 and ERK pathways activation. Cell Communication and Signaling, 22, Article 214. https://doi.org/10.1186/s12964-024-01594-x | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 29.11.2024 | |||||||
| Dateien geändert am: | 29.11.2024 |
