Dokument: Time-resolved quantification of fine hand movements as a proxy for evaluating bradykinesia-induced motor dysfunction
| Titel: | Time-resolved quantification of fine hand movements as a proxy for evaluating bradykinesia-induced motor dysfunction | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67754 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241128-115658-9 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Spooner, Rachel K. [Autor] Bahners, Bahne Hendrik [Autor] Schnitzler, Alfons [Autor] Florin, Esther [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Finger-tapping, Single-trial, Parkinson’s disease, Pronation-supination, Accelerometer, Bradykinesia | |||||||
| Beschreibung: | Bradykinesia is a behavioral manifestation that contributes to functional dependencies in later life. However, the current state of bradykinesia indexing primarily relies on subjective, time-averaged categorizations of motor deficits, which often yield poor reliability. Herein, we used time-resolved analyses of accelerometer recordings during standardized movements, data-driven factor analyses, and linear mixed effects models (LMEs) to quantitatively characterize general, task- and therapy-specific indices of motor impairment in people with Parkinson’s disease (PwP) currently undergoing treatment for bradykinesia. Our results demonstrate that single-trial, accelerometer-based features of finger-tapping and rotational hand movements were significantly modulated by divergent therapeutic regimens. Further, these features corresponded well to current gold standards for symptom monitoring, with more precise predictive capacities of bradykinesia-specific declines achieved when considering kinematic features from diverse movement types together, rather than in isolation. Herein, we report data-driven, sample-specific kinematic profiles of diverse movement types along a continuous spectrum of motor impairment, which importantly, preserves the temporal scale for which biomechanical fluctuations in motor deficits evolve in humans. Therefore, this approach may prove useful for tracking bradykinesia-induced motor decline in aging populations the future. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Spooner, R. K., Bahners, B. H., Schnitzler, A., & Florin, E. (2024). Time-resolved quantification of fine hand movements as a proxy for evaluating bradykinesia-induced motor dysfunction. Scientific Reports, 14, Article 5340. https://doi.org/10.1038/s41598-024-55862-4 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 28.11.2024 | |||||||
| Dateien geändert am: | 28.11.2024 |
