Dokument: Pectoral muscle mass is not a robust prognostic factor for survival after left ventricular assist device (LVAD) implantation
| Titel: | Pectoral muscle mass is not a robust prognostic factor for survival after left ventricular assist device (LVAD) implantation | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67726 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241127-110744-5 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Jenkins, Freya Sophie [Autor] Minol, Jan-Philipp [Autor] Akar, Tarik [Autor] Yilmaz, Esma [Autor] Immohr, Moritz Benjamin [Autor] Dalyanoglu, Ismail [Autor] Korbmacher, Bernhard [Autor] Aissa, Joel [Autor] Boeken, Udo [Autor] Lichtenberg, Artur [Autor] | |||||||
| Dateien: |
| |||||||
| Stichwörter: | Left ventricular heart failure, Pectoral muscle mass, Left ventricular assist device, Frailty | |||||||
| Beschreibung: | Background
Left ventricular assist devices (LVAD) are an established treatment for end-stage left ventricular heart failure. Parameters are needed to identify the most appropriate patients for LVADs. This study aimed to evaluate pectoral muscle mass and density as prognostic parameters. Methods This single-center study included all patients with LVAD implantation between January 2010 and October 2017 and a preoperative chest CT scan. Pectoral muscle mass was assessed using the Pectoralis Muscle Index (PMI, surface area indexed to height, cm2/m2) and pectoral muscle density by Hounsfield Units (HU). Overall mortality was analyzed with Kaplan–Meier survival analysis and 1-year and 3-year mortality with receiver operating characteristic (ROC) curves and Cox regression models. Results 57 patients (89.5% male, mean age 57.8 years) were included. 64.9% of patients had end-stage left ventricular failure due to ischemic heart disease and 35.1% due to dilated cardiomyopathy. 49.2% of patients had preoperative INTERMACS profile of 1 or 2 and 33.3% received mechanical circulatory support prior to LVAD implantation. Total mean PMI was 4.7 cm2/m2 (± 1.6), overall HU of the major pectoral muscle was 39.0 (± 14.9) and of the minor pectoral muscle 37.1 (± 16.6). Mean follow-up was 2.8 years (± 0.2). Mortality rates were 37.5% at 1 year and 48.0% at 3 years. Neither PMI nor HU were significantly associated with overall mortality at 1-year or 3-year. Conclusions The results of our study do not confirm the association between higher pectoral muscle mass and better survival after LVAD implantation previously described in the literature. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Jenkins, F. S., Minol, J.-P., Akar, T., Yilmaz, E., Immohr, M. B., Dalyanoglu, I., Korbmacher, B., Aissa, J., Boeken, U., Lichtenberg , A., Akhyari, P., & Hannan, D. (2024). Pectoral muscle mass is not a robust prognostic factor for survival after left ventricular assist device (LVAD) implantation. Journal of Cardiothoracic Surgery, 19, Article 76. https://doi.org/10.1186/s13019-024-02547-8 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 27.11.2024 | |||||||
| Dateien geändert am: | 27.11.2024 |
