Dokument: GTP before ATP: The energy currency at the origin of genes
| Titel: | GTP before ATP: The energy currency at the origin of genes | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67651 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241122-114709-1 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Mrnjavac, Natalia [Autor] Martin, William F. [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Ribosome, Origin of life, Acyl phosphates, Acetyl-CoA pathway, ATP synthase, Origin of translation | |||||||
| Beschreibung: | Life is an exergonic chemical reaction. Many individual reactions in metabolism entail slightly endergonic steps that are coupled to free energy release, typically as ATP hydrolysis, in order to go forward. ATP is almost always supplied by the rotor-stator ATP synthase, which harnesses chemiosmotic ion gradients. Because the ATP synthase is a protein, it arose after the ribosome did. What was the energy currency of metabolism before the origin of the ATP synthase and how (and why) did ATP come to be the universal energy currency? About 27 % of a cell's energy budget is consumed as GTP during translation. The universality of GTP-dependence in ribosome function indicates that GTP was the ancestral energy currency of protein synthesis. The use of GTP in translation and ATP in small molecule synthesis are conserved across all lineages, representing energetic compartments that arose in the last universal common ancestor, LUCA. And what came before GTP? Recent findings indicate that the energy supporting the origin of LUCA's metabolism stemmed from H2-dependent CO2 reduction along routes that strongly resemble the reactions and transition metal catalysts of the acetyl-CoA pathway. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Mrnjavac, N., & Martin, W. F. (2024). GTP before ATP: The energy currency at the origin of genes. Biochimica et Biophysica Acta Bioenergetics, 1866(1), Article 149514. https://doi.org/10.1016/j.bbabio.2024.149514 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 22.11.2024 | |||||||
| Dateien geändert am: | 22.11.2024 |
