Dokument: Evaluation of binders in twin-screw wet granulation – Optimization of tabletability
| Titel: | Evaluation of binders in twin-screw wet granulation – Optimization of tabletability | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67627 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241121-112452-5 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Köster, Claudia [Autor] Kleinebudde, Peter [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Wet granulation, Tablet, Twin-screw granulation, Tablet tensile strength, Tablet disintegration, Binder | |||||||
| Beschreibung: | The influence of hydroxypropyl cellulose type (HPC-SSL SFP, HPC-SSL), concentration (2 %, 3.5 %, 5 %) and filler (lactose, calcium hydrogen phosphate (DCP)/microcrystalline cellulose (MCC)) on twin-screw wet granulation and subsequent tableting was studied. The aim was to identify the formulation of the highest tabletability which still fulfills the requirements of the disintegration. Lactose combined with 5 % binder enabled a higher tabletability and a faster disintegration than DCP/MCC. It was found that tabletability of lactose formulations can be increased by higher binder concentration and higher compression pressure while tabletability of DCP/MCC formulations can be only increased by higher compression pressure. It was observed that batches containing DCP/MCC failed the disintegration test, if the highest binder concentration and the highest compression pressure were used. To ensure a fast disintegration, the compression pressure or at least the binder concentration had to be low. Changing the disintegrant and its localization improved the DCP/MCC formulation, resulting in faster disintegration than lactose tablets. However, it also resulted in a lower tabletability. In this study best tablets were achieved with 3.5 % or 5 % binder and lactose as filler. These tablets presented the highest tabletability but still disintegrated in less than 500 s. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Köster, C., & Kleinebudde, P. (2024). Evaluation of binders in twin-screw wet granulation – Optimization of tabletability. International Journal of Pharmaceutics, 659, Article 124290. https://doi.org/10.1016/j.ijpharm.2024.124290 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 21.11.2024 | |||||||
| Dateien geändert am: | 21.11.2024 |
