Dokument: Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases
| Titel: | Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67585 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241118-121457-2 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Zhou, Huakang [Autor] Khan, Dilaware [Autor] Hussain, Sajid Muhammad [Autor] Gerdes, Norbert [Autor] Hagenbeck, Carsten [Autor] Rana, Majeed [Autor] Cornelius, Jan Frederick [Autor] Muhammad, Sajjad [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Colchicine, Cellular senescence, MAPKs, Oxidative stress, Inflammation, NFκ-B, mTOR, Endothelial cells | |||||||
| Beschreibung: | Background
Smoking, alcohol abuse, and hypertension are – among others, potential risk factors for cardiovascular diseases. These risk factors generate oxidative stress and cause oxidative stress-induced DNA damage, resulting in cellular senescence and senescence-associated secretory phenotype (SASP). The SASP factors in feed-forward response exacerbate inflammation and cause tissue remodeling, resulting in atherosclerotic plaque formation and rupture. Results Colchicine inhibited ROS generation and mitigated oxidative stress-induced DNA damage. It dampened oxidative stress-induced endothelial cell senescence and improved the expression of DNA repair protein KU80 and aging marker Lamin B1. The drug attenuated the expression of senescence marker P21 at mRNA and protein levels. The pathway analysis showed that colchicine inhibited NF-κB and MAPKs pathways and subdued mTOR activation. Colchicine also attenuated mRNA expression of interleukin (IL)-1β, IL-6, IL-8, MCP-1, ICAM-1, and E-selectin. Furthermore, colchicine reduced the mRNA and protein expression of matrix metalloproteinase (MMP-2). Conclusion In summary, colchicine blocked oxidative stress-induced senescence and SASP by inhibiting the activation of NF-κB and MAPKs pathways. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Zhou, H., Khan, D., Hussain, S. M., Gerdes, N., Hagenbeck, C., Rana, M., Cornelius, J. F., & Muhammad, S. (2023). Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases. Journal of Inflammation, 20, Article 41. https://doi.org/10.1186/s12950-023-00366-7 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 18.11.2024 | |||||||
| Dateien geändert am: | 18.11.2024 |
