Dokument: CD73 deficiency does not aggravate angiotensin II-induced aortic inflammation in mice
| Titel: | CD73 deficiency does not aggravate angiotensin II-induced aortic inflammation in mice | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67533 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241115-103859-4 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Massold, Timo [Autor] Ibrahim, Fady [Autor] Niemann, Viola [Autor] Steckel, Bodo [Autor] Becker, Katrin [Autor] Schrader, Jürgen [Autor] Stegbauer, Johannes [Autor] Temme, Sebastian [Autor] Grandoch, Maria [Autor] Flögel, Ulrich [Autor] | |||||||
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| Beschreibung: | Vascular inflammation plays a key role in the development of aortic diseases. A potential novel target for treatment might be CD73, an ecto-5′-nucleotidase that generates anti-inflammatory adenosine in the extracellular space. Here, we investigated whether a lack of CD73 results in enhanced aortic inflammation. To this end, angiotensin II was infused into wildtype and CD73−/− mice over 10 days. Before and after infusion, mice were analyzed using magnetic resonance imaging, ultrasound, flow cytometry, and histology. The impact of age and gender was investigated using female and male mice of three and six months of age, respectively. Angiotensin II infusion led to increased immune cell infiltration in both genotypes’ aortae, but depletion of CD73 had no impact on immune cell recruitment. These findings were not modified by age or sex. No substantial difference in morphological or functional characteristics could be detected between wildtype and CD73−/− mice. Interestingly, the expression of CD73 on neutrophils decreased significantly in wildtype mice during treatment. In summary, we have found no evidence that CD73 deficiency affects the onset of aortic inflammation. However, as CD73 expression decreased during disease induction, an increase in CD73 by pharmaceutical intervention might result in lower vascular inflammation and less vascular disease. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Massold, T., Ibrahim, F., Niemann, V., Steckel, B., Becker, K., Schrader, J., Stegbauer, J., Temme, S., Grandoch, M., Flögel, U., & Bouvain, P. (2023). CD73 deficiency does not aggravate angiotensin II-induced aortic inflammation in mice. Scientific Reports, 13, Article 17125. https://doi.org/10.1038/s41598-023-44361-7 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 15.11.2024 | |||||||
| Dateien geändert am: | 15.11.2024 |
