Dokument: Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes
| Titel: | Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67407 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241108-101743-5 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Rafii, Puyan [Autor] Seibel, Christiane [Autor] Weitz, Hendrik T. [Autor] Ettich, Julia [Autor] Minafra, Anna Rita [Autor] Petzsch, Patrick [Autor] Lang, Alexander [Autor] Floss, Doreen M. [Autor] Behnke, Kristina [Autor] Köhrer, Karl [Autor] | |||||||
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| Beschreibung: | All except one cytokine of the Interleukin (IL-)6 family share glycoprotein (gp) 130 as the common β receptor chain. Whereas Interleukin (IL-)11 signal via the non-signaling IL-11 receptor (IL-11R) and gp130 homodimers, leukemia inhibitory factor (LIF) recruits gp130:LIF receptor (LIFR) heterodimers. Using IL-11 as a framework, we exchange the gp130-binding site III of IL-11 with the LIFR binding site III of LIF. The resulting synthetic cytokimera GIL-11 efficiently recruits the non-natural receptor signaling complex consisting of gp130, IL-11R and LIFR resulting in signal transduction and proliferation of factor-depending Ba/F3 cells. Besides LIF and IL-11, GIL-11 does not activate receptor complexes consisting of gp130:LIFR or gp130:IL-11R, respectively. Human GIL-11 shows cross-reactivity to mouse and rescued IL-6R−/− mice following partial hepatectomy, demonstrating gp130:IL-11R:LIFR signaling efficiently induced liver regeneration. With the development of the cytokimera GIL-11, we devise the functional assembly of the non-natural cytokine receptor complex of gp130:IL-11R:LIFR. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Rafii, P., Seibel, C., Weitz, H. T., Ettich, J., Minafra, A. R., Petzsch, P., Lang, A., Floß, D. M., Behnke, K., Köhrer, K., Moll, J. M., & Scheller, J. (2023). Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes [OnlineRessource]. Communications Biology, 6, Article 418. https://doi.org/10.1038/s42003-023-04768-4 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 08.11.2024 | |||||||
| Dateien geändert am: | 08.11.2024 |
