Dokument: Evaluation of risk factors for cytomegalovirus DNAemia after end of regular prophylaxis after heart transplantation
| Titel: | Evaluation of risk factors for cytomegalovirus DNAemia after end of regular prophylaxis after heart transplantation | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67301 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241031-115924-8 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Immohr, Moritz Benjamin [Autor] Oehler, Daniel [Autor] Jenkins, Freya Sophie [Autor] Kalampokas, Nikolaos [Autor] Hettlich, Vincent [Autor] Sigetti, Dennis [Autor] Voß, Fabian [Autor] Hannan, Dalyanoglu [Autor] Aubin, Hug [Autor] Akhyari, Payam [Autor] | |||||||
| Dateien: |
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| Stichwörter: | prophylaxis, cardiac allograft vasculopathy, heart transplantation, cytomegalovirus | |||||||
| Beschreibung: | Background:
Cytomegalovirus (CMV) infections after heart transplantation (HTx) can cause cardiac allograft vasculopathy. Consequently, monitoring and prophylaxis for cytomegalovirus deoxyribonucleic acid (CMV‐DNAemia) within the first weeks after HTx is recommended. Methods: All patients who underwent HTx between September 2010 and 2021 surviving the first 90 days (n = 196) were retrospectively reviewed. The patients were divided on the prevalence of CMV‐DNAemia during the first postoperative year after the end of the prophylaxis. A total of n = 35 (20.1%) developed CMV‐DNAemia (CMV group) and were compared to patients without CMV‐DNAemia (controls, n = 139). The remaining patients (n = 22) were excluded due to incomplete data. Results: Positive donors and negative recipients (D+/R−) and negative donors and positive recipients (D−/R+) serology was significantly increased and D−/R− decreased in the CMV group (p < .01). Furthermore, the mean age was 57.7 ± 8.7 years but only 53.6 ± 10.0 years for controls (p = .03). Additionally, the intensive care unit (p = .02) and total hospital stay (p = .03) after HTx were approximately 50% longer. Interestingly, the incidence of CMV‐DNAemia during prophylaxis was only numerically increased in the CMV group (5.7%, respectively, 0.7%, p = .10), the same effect was also observed for postoperative infections. Multivariate analyses confirmed that D+/R− and D−/R+ CMV immunoglobulin G match were independent risk factors for postprophylaxis CMV‐DNAemia. Conclusion: Our data should raise awareness of CMV‐DNAemia after the termination of regular prophylaxis, as this affects one in five HTx patients. Especially old recipients as well as D+/R− and D−/R+ serology share an elevated. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Immohr, M. B., Oehler, D., Jenkins, F. S., Kalampokas, N., Hettlich, V., Sigetti, D., Voß, F., Hannan, D., Aubin, H., Akhyari, P., Lichtenberg , A., & Boeken, U. (2023). Evaluation of risk factors for cytomegalovirus DNAemia after end of regular prophylaxis after heart transplantation. Immunity, Inflammation and Disease, 11(11), Article e1075. https://doi.org/10.1002/iid3.1075 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 31.10.2024 | |||||||
| Dateien geändert am: | 31.10.2024 |
