Dokument: A Systematic Compilation of Human SH3 Domains: A Versatile Superfamily in Cellular Signaling
| Titel: | A Systematic Compilation of Human SH3 Domains: A Versatile Superfamily in Cellular Signaling | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67172 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241023-112429-6 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Mehrabipour, Mehrnaz [Autor] Kazemein Jasemi, Neda S. [Autor] Dvorsky, Radovan [Autor] Ahmadian, Mohammad Reza [Autor] | |||||||
| Dateien: |
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| Stichwörter: | SRC homology 3, signal transduction, protein interaction, SH3 domain-containing proteins, proline-rich motifs (PRM), SH3 domain | |||||||
| Beschreibung: | SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of protein complexes through physical interactions with a pool of proline-rich/noncanonical motifs from partner proteins. They are widely studied modular building blocks across all five kingdoms of life and viruses, mediating various biological processes. The SH3 domains are also implicated in the development of human diseases, such as cancer, leukemia, osteoporosis, Alzheimer’s disease, and various infections. A database search of the human proteome reveals the existence of 298 SH3 domains in 221 SH3 domain-containing proteins (SH3DCPs), ranging from 13 to 720 kilodaltons. A phylogenetic analysis of human SH3DCPs based on their multi-domain architecture seems to be the most practical way to classify them functionally, with regard to various physiological pathways. This review further summarizes the achievements made in the classification of SH3 domain functions, their binding specificity, and their significance for various diseases when exploiting SH3 protein modular interactions as drug targets. | |||||||
| Rechtliche Vermerke: | Originalveröffenlichung:
Mehrabipour, M., Kazemein Jasemi, N. S., Dvorsky, R., & Ahmadian, M. R. (2023). A Systematic Compilation of Human SH3 Domains: A Versatile Superfamily in Cellular Signaling. Cells, 12(16), Article 2054. https://doi.org/10.3390/cells12162054 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 23.10.2024 | |||||||
| Dateien geändert am: | 23.10.2024 |
