Dokument: The Microenvironment of the Pathogenesis of Cardiac Hypertrophy
| Titel: | The Microenvironment of the Pathogenesis of Cardiac Hypertrophy | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67150 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241022-104254-1 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Bazgir, Farhad [Autor] Nau, Julia [Autor] Nakhaei-Rad, Saeideh [Autor] Amin, Ehsan [Autor] Wolf, Matthew J. [Autor] Saucerman, Jeffry J. [Autor] Lorenz, Kristina [Autor] Ahmadian, Mohammad Reza [Autor] | |||||||
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| Stichwörter: | vasoactive hormones, cardiomyocytes, myocardial microenvironment, myofibroblasts, pressure overload, cardiac hypertrophy, heart failure, scar formation | |||||||
| Beschreibung: | Pathological cardiac hypertrophy is a key risk factor for the development of heart failure and predisposes individuals to cardiac arrhythmia and sudden death. While physiological cardiac hypertrophy is adaptive, hypertrophy resulting from conditions comprising hypertension, aortic stenosis, or genetic mutations, such as hypertrophic cardiomyopathy, is maladaptive. Here, we highlight the essential role and reciprocal interactions involving both cardiomyocytes and non-myocardial cells in response to pathological conditions. Prolonged cardiovascular stress causes cardiomyocytes and non-myocardial cells to enter an activated state releasing numerous pro-hypertrophic, pro-fibrotic, and pro-inflammatory mediators such as vasoactive hormones, growth factors, and cytokines, i.e., commencing signaling events that collectively cause cardiac hypertrophy. Fibrotic remodeling is mediated by cardiac fibroblasts as the central players, but also endothelial cells and resident and infiltrating immune cells enhance these processes. Many of these hypertrophic mediators are now being integrated into computational models that provide system-level insights and will help to translate our knowledge into new pharmacological targets. This perspective article summarizes the last decades’ advances in cardiac hypertrophy research and discusses the herein-involved complex myocardial microenvironment and signaling components. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Bazgir, F., Nau, J., Nakhaei-Rad, S., Amin, E., Wolf, M. J., Saucerman, J. J., Lorenz, K., & Ahmadian, M. R. (2023). The Microenvironment of the Pathogenesis of Cardiac Hypertrophy. Cells, 12(13), Article 1780. https://doi.org/10.3390/cells12131780 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 22.10.2024 | |||||||
| Dateien geändert am: | 22.10.2024 |
