Dokument: Colchicine Protects against Ethanol-Induced Senescence and Senescence-Associated Secretory Phenotype in Endothelial Cells
| Titel: | Colchicine Protects against Ethanol-Induced Senescence and Senescence-Associated Secretory Phenotype in Endothelial Cells | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=67056 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20241015-114034-4 | |||||||
| Kollektion: | Publikationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Texte » Artikel, Aufsatz | |||||||
| Medientyp: | Text | |||||||
| Autoren: | Zhou, Huakang [Autor] Khan, Dilaware [Autor] Gerdes, Norbert [Autor] Hagenbeck, Carsten [Autor] Rana, Majeed [Autor] Cornelius, Jan Frederick [Autor] Muhammad, Sajjad [Autor] | |||||||
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| Stichwörter: | NFk-B, ethanol, inflammation, HUVECs, SASP, MAPKs, cellular senescence, colchicine | |||||||
| Beschreibung: | Inflammaging is a potential risk factor for cardiovascular diseases. It results in the development of thrombosis and atherosclerosis. The accumulation of senescent cells in vessels causes vascular inflammaging and contributes to plaque formation and rupture. In addition to being an acquired risk factor for cardiovascular diseases, ethanol can induce inflammation and senescence, both of which have been implicated in cardiovascular diseases. In the current study, we used colchicine to abate the cellular damaging effects of ethanol on endothelial cells. Colchicine prevented senescence and averted oxidative stress in endothelial cells exposed to ethanol. It lowered the relative protein expression of aging and senescence marker P21 and restored expression of the DNA repair proteins KU70/KU80. Colchicine inhibited the activation of nuclear factor kappa B (NFκ-B) and mitogen activated protein kinases (MAPKs) in ethanol-treated endothelial cells. It reduced ethanol-induced senescence-associated secretory phenotype. In summary, we show that colchicine ameliorated the ethanol-caused molecular events, resulting in attenuated senescence and senescence-associated secretory phenotype in endothelial cells. | |||||||
| Rechtliche Vermerke: | Originalveröffentlichung:
Zhou, H., Khan, D., Gerdes, N., Hagenbeck, C., Rana, M., Cornelius, J. F., & Muhammad, S. (2023). Colchicine Protects against Ethanol-Induced Senescence and Senescence-Associated Secretory Phenotype in Endothelial Cells [OnlineRessource]. Antioxidants, 12(4), Article 960. https://doi.org/10.3390/antiox12040960 | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 15.10.2024 | |||||||
| Dateien geändert am: | 16.10.2024 |
