Dokument: Die Gewichtsentwicklung bei Menschen mit schweren psychischen Erkrankungen während einer stationären psychiatrischen Behandlung - Ergebnisse eines internationalen Qualitätssicherungsprogramms
Titel: | Die Gewichtsentwicklung bei Menschen mit schweren psychischen Erkrankungen während einer stationären psychiatrischen Behandlung - Ergebnisse eines internationalen Qualitätssicherungsprogramms | |||||||
Weiterer Titel: | Weight change in people with severe mental illnesses during inpatient psychiatric treatment - Results of an international quality assurance program | |||||||
URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=65158 | |||||||
URN (NBN): | urn:nbn:de:hbz:061-20240308-113614-9 | |||||||
Kollektion: | Dissertationen | |||||||
Sprache: | Deutsch | |||||||
Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
Medientyp: | Text | |||||||
Autor: | Peter, Stephanie Christina Maria [Autor] | |||||||
Dateien: |
| |||||||
Beitragende: | Prof. Dr. Cordes, Joachim [Gutachter] Prof. Dr. Wilm, Stefan [Gutachter] | |||||||
Stichwörter: | Gewichtszunahme; psychische Erkrankung; stationäre psychiatrische Behandlung; weight gain; severe mental illness; inpatient psychiatric treatment | |||||||
Dewey Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit | |||||||
Beschreibungen: | Gewichtszunahme bei Menschen mit schweren psychischen Erkrankungen ist aufgrund der
damit einhergehenden somatischen Komorbidität, psychischen Folgewirkungen und Auswirkungen auf die Compliance der Behandlung ein klinisch relevantes Phänomen. Basierend auf bisherigen Forschungsergebnissen haben zahlreiche Faktoren Einfluss auf die Gewichtsentwicklung von Menschen mit schweren psychischen Erkrankungen während einer Hospitalisierung. Hierzu gehören der Body-Mass-Index (BMI) bei Aufnahme, das Alter, das Geschlecht, die Art der psychischen Erkrankung und die verabreichte psychiatrische Medikation und auch der ethnische Hintergrund des Patienten sowie die länderspezifischen Behandlungsbedingungen. Die vorliegende Auswertung ist Teil eines internationalen Qualitätssicherungsprogramms zur anonymisierten Erhebung von Variablen aller Patienten bei Aufnahme und Entlassung einer stationären psychiatrischen Behandlung in fünf Ländern von Mai 2003 bis Juni 2006 auf definierten Behandlungseinheiten. Fragestellung der vorliegenden Arbeit war, ob und welche Patienten im Rahmen einer stationären Behandlung durchschnittlich an Gewicht zunehmen und welche Einflussfaktoren auf die Gewichtszunahme sich identifizieren lassen. Von ursprünglich 2338 anonymisiert in das Qualitätssicherungsprogramms eingeschlossenen Patienten lagen bei 876 Patienten die auszuwertenden anonymisierten Variablen für diese Fragestellung vor. Die in die Auswertung eingeschlossenen Patienten wurden in psychiatrischen Einrichtungen in West-Europa (Dänemark, Deutschland und Schweiz; N = 466), Nigeria (N = 265) und Japan (N = 145) aufgenommen und behandelt. Es zeigten sich signifikante Effekte der Variablen Behandlungsland, afrikanische Abstammung, BMI bei Aufnahme, psychiatrische Diagnose und psychiatrische Medikation auf das Ausmaß der Gewichtszunahme während der stationären Behandlung. Die Variable Alter zeigte nur bei Patienten in Nigeria einen signifikanten Einfluss auf die Gewichtsentwicklung, die Variable Geschlecht nur bei Patienten, die in Dänemark behandelt wurden. Die Variablen psychiatrische Diagnose und psychiatrische Medikation zeigten verschiedene Effekte in den unterschiedlichen Ländern.Weight gain among people with severe mentally illness is a clinically relevant phenomenon because of its somatic comorbidities, psychological effects and influences on patients´ treatment compliance. Based on recent research there are several factors influencing weight change of people with severe mental illness during hospitalisation including Body-Mass-Index (BMI) on admission, age, sex, psychiatric diagnosis and psychiatric medication as well as patient´s racial background and the country-specific treatment conditions. The present analysis is part of an international Quality Assurance Program to an anonymized collection of variables of all patients at admission and discharge from inpatient psychiatric treatment in 5 countries from may 2003 to june 2006 on defined treatment units. Aim of this work was to find out if patients with severe mental illness experience weight gain during hospitalisation and to identify which patients are in danger of weight gain during stationary psychiatric treatment as well as the factors which are involved in this effect. 876 of originally 2338 patients which were anonymously included in this Quality Assurance Program met the criteria for this analysis. Patients were recruited and examined in mental health care centres in Western-Europe (Denmark, Germany and Switzerland; N = 466), Nigeria (N = 265) and Japan (N = 145). The analysis showed significant effects of the variables country of treatment, african origin, BMI at admission, psychiatric diagnosis and psychiatric medication on the amount of weight gain during hospitalisation. The factor age only showed a significant effect in patients in Nigeria. The factor sex showed significant effects only in patients in Denmark. The factors psychiatric diagnosis and psychiatric medication showed different effects in different countries. | |||||||
Quelle: | Agelink, M. W., Kornischka, J., Cordes, J., Klimke, A., Hauner, H., & Ziegler. (2006). Deutsches Ärzteblatt: Archiv „Allgemeinmedizinische Aspekte der Therapie mit Antipsychotika der zweiten Generation“ (20.10.2006). https://www.aerzteblatt.de/pdf.asp?id=53161
Ananth, J., Kolli, S., Gunatilake, S., & Brown, S. (2005). Atypical antipsychotic drugs, diabetes and ethnicity. Expert Opinion on Drug Safety, 4(6), 1111–1124. https://doi.org/10.1517/14740338.4.6.1111 Andersen, S. W., Clemow, D. B., & Corya, S. A. (2005). Long-Term Weight Gain in Patients Treated With Open-Label Olanzapine in Combination With Fluoxetine for Major Depressive Disorder. The Journal of Clinical Psychiatry, 66(11), 1468–1476. Barke, A., & Klecha, D. (2003). Psychisch Kranke in Nigeria: Versteckt in der dunklen Ecke. Deutsches Ärzteblatt. Heft 24, 100: A 1662-1663. https://www.aerzteblatt.de/archiv/37661/Psychisch-Kranke-in-Nigeria-Versteckt-in-der-dunklen-Ecke Basson, B. R., Kinon, B. J., Taylor, C. C., Szymanski, K. A., Gilmore, J. A., & Tollefson, G. D. (2001). Factors influencing acute weight change in patients with schizophrenia treated with olanzapine, haloperidol, or risperidone. The Journal of Clinical Psychiatry, 62(4), 231–238. Belgardt, B.-F. (2010). Obesity-linked dysfunction of hypothalamic and pituitary circuits in regulation of energy homeostasis [Text.thesis.doctoral, Universität zu Köln]. http://kups.ub.uni-koeln.de/3273/ Bermudes, R. A., Keck, P. E., & McElroy, S. L. (2007). Managing Metabolic Abnormalities in the Psychiatrically Ill: A Clinical Guide for Psychiatrists. American Psychiatric Publishing, Inc. Bet, P. M., Hugtenburg, J. G., Penninx, B. W. J. H., & Hoogendijk, W. J. G. (2013). Side effects of antidepressants during long-term use in a naturalistic setting. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 23(11), 1443–1451. https://doi.org/10.1016/j.euroneuro.2013.05.001 Bleuler, E. (1911). Dementia praecox. Deuticke, Leipzig. Brown, S., Birtwistle, J., Roe, L., & Thompson, C. (1999). The unhealthy lifestyle of people with schizophrenia. Psychological Medicine, 29(3), 697–701. Cao, H., Chen, J., Meyer-Lindenberg, A., & Schwarz, E. (2017). A polygenic score for schizophrenia predicts glycemic control. Translational Psychiatry, 7(12), 1295. https://doi.org/10.1038/s41398-017-0044-z Casey, D. E., & Zorn, S. H. (2001). The pharmacology of weight gain with antipsychotics. The Journal of Clinical Psychiatry, 62 Suppl 7, 4–10. Chan, L. F., Zai, C., Monda, M., Potkin, S., Kennedy, J. L., Remington, G., Lieberman, J., Meltzer, H. Y., & De Luca, V. (2013). Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia: Genes or environment? Pharmacogenomics, 14(11), 1273–1281. https://doi.org/10.2217/pgs.13.127 Cheng, C.-Y., Kao, W. H. L., Patterson, N., Tandon, A., Haiman, C. A., Harris, T. B., Xing, C., John, E. M., Ambrosone, C. B., Brancati, F. L., Coresh, J., Press, M. F., Parekh, R. S., Klag, M. J., Meoni, L. A., Hsueh, W.-C., Fejerman, L., Pawlikowska, L., Freedman, M. L., … Reich, D. (2009). Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X. PLoS Genetics, 5(5), e1000490. https://doi.org/10.1371/journal.pgen.1000490 Cordes, J., Hauner, Klimke, A., Agelink, M. W., Kornischka, J., & Wormer, E. J. (2006a). Bei Gewichtszunahme erfolgreich intervenieren. Der Neurologe & Psychiater. Cordes, J., Klimke, A., Kornischka, J., & Hauner, H. (2006b). Therapie der Schizophrenie mit Antipsychotika: Gewichtszunahme ist ein relevanter Faktor. Der Neurologe & Psychiater, 1–2, 45–51. Cossrow, N., & Falkner, B. (2004). Race/ethnic issues in obesity and obesity-related comorbidities. The Journal of Clinical Endocrinology and Metabolism, 89(6), 2590–2594. https://doi.org/10.1210/jc.2004-0339 Dayabandara, M., Hanwella, R., Ratnatunga, S., Seneviratne, S., Suraweera, C., & de Silva, V. A. (2017). Antipsychotic-associated weight gain: Management strategies and impact on treatment adherence. Neuropsychiatric Disease and Treatment, 13, 2231–2241. https://doi.org/10.2147/NDT.S113099 Engelke, C., Lange-Asschenfeldt, C., Peter, S., Kahl, K. G., Frasch, K., Larsen, J. I., Bickel, G. G., Bork, B., Jacobsen, B. A., Wallenstein-Jensen, S. O., Lauber, C., Mogensen, B., Nielsen, J. A., Rössler, W., Tsuchiya, K. J., Toftegaard, K. L., Andersen, U. A., Uwakwe, R., Munk-Jørgensen, P., & Cordes, J. (2017). A cross-continental analysis of weight gain, psychiatric diagnoses and medication use during inpatient psychiatric treatment. The international study on physical illness in mentally ill. European Psychiatry: The Journal of the Association of European Psychiatrists, 48, 65–70. https://doi.org/10.1016/j.eurpsy.2017.11.004 Esquirol, J. E. D. (1838). Die Geisteskrankheiten in Beziehung zur Medizin und Staatsarzneikunde. Voß, Berlin. Fagiolini, A., Frank, E., Houck, P. R., Mallinger, A. G., Swartz, H. A., Buysse, D. J., Ombao, H., & Kupfer, D. J. (2002). Prevalence of obesity and weight change during treatment in patients with bipolar I disorder. The Journal of Clinical Psychiatry, 63(6), 528–533. Gates, M. L., Wilkins, T., Ferguson, E., Walker, V., Bradford, R. K., & Yoo, W. (2016). Gender and race disparities in weight gain among offenders prescribed antidepressant and antipsychotic medications. Health & Justice, 4, 6. https://doi.org/10.1186/s40352-016-0037-7 Geiser, A. (2009). Nigeria: Behandlung von PTSD. . . November, 7. https://www.fluechtlingshilfe.ch/assets/herkunftslaender/afrika/nigeria/nigeria-behandlung-von-ptsd.pdf. Global BMI Mortality Collaboration, null, Di Angelantonio, E., Bhupathiraju, S., Wormser, D., Gao, P., Kaptoge, S., Berrington de Gonzalez, A., Cairns, B., Huxley, R., Jackson, C., Joshy, G., Lewington, S., Manson, J., Murphy, N., Patel, A., Samet, J., Woodward, M., Zheng, W., Zhou, M., … Hu, F. (2016). Body-mass index and all-cause mortality: Individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet (London, England), 388(10046), 776–786. https://doi.org/10.1016/S0140-6736(16)30175-1 Heald, A., Pendlebury, J., Anderson, S., Narayan, V., Guy, M., Gibson, M., Haddad, P., & Livingston, M. (2017). Lifestyle factors and the metabolic syndrome in Schizophrenia: A cross-sectional study. Annals of General Psychiatry, 16, 12. https://doi.org/10.1186/s12991-017-0134-6 Herold, G. (2007). Innere Medizin. Holt, R. I. G., Abdelrahman, T., Hirsch, M., Dhesi, Z., George, T., Blincoe, T., & Peveler, R. C. (2010). The prevalence of undiagnosed metabolic abnormalities in people with serious mental illness. Journal of Psychopharmacology (Oxford, England), 24(6), 867–873. https://doi.org/10.1177/0269881109102788 Holt, R. I. G., & Peveler, R. C. (2009). Obesity, serious mental illness and antipsychotic drugs. Diabetes, Obesity & Metabolism, 11(7), 665–679. https://doi.org/10.1111/j.1463-1326.2009.01038.x Ising, M. (2012). Stresshormonregulation und Depressionsrisiko – Perspektiven für die antidepressive Behandlung | Max-Planck-Gesellschaft. https://www.mpg.de/4752810/Antidepressive_Behandlung Klecha, D., Barke, A., & Gureje, O. (2004). [Mental health care in developing countries: The example of Nigeria]. Der Nervenarzt, 75(11), 1118–1122. https://doi.org/10.1007/s00115-003-1653-8 Koga, M. (2003). [Clinical factors related to gains in body mass index (BMI) among patients under long-term antipsychotic treatment]. Seishin Shinkeigaku Zasshi = Psychiatria Et Neurologia Japonica, 105(4), 473–488. Kouidrat, Y., Amad, A., Lalau, J.-D., & Loas, G. (2014). Eating disorders in schizophrenia: Implications for research and management. Schizophrenia Research and Treatment, 2014, 791573. https://doi.org/10.1155/2014/791573 Kraepelin, E. (1913). Psychiatrie (8.). Johann Ambrosius Barth, Leipzig. Krakowski, M., Czobor, P., & Citrome, L. (2009). Weight gain, metabolic parameters, and the impact of race in aggressive inpatients randomized to double-blind clozapine, olanzapine or haloperidol. Schizophrenia Research, 110(1–3), 95–102. https://doi.org/10.1016/j.schres.2009.02.006 Kraus, T., Zimmermann, U., Schuld, A., Haack, M., Hinze-Selch, D., & Pollmächer, T. (2001). [The physiopathology of weight regulation during treatment with psychotropic drugs]. Fortschritte Der Neurologie-Psychiatrie, 69(3), 116–137. https://doi.org/10.1055/s-2001-12278 Kuntz, B., & Lampert, T. (2010). Socioeconomic factors and obesity. Deutsches Arzteblatt International, 107(30), 517–522. https://doi.org/10.3238/arztebl.2010.0517 Lane, H.-Y., Chang, Y.-C., Cheng, Y.-C., Liu, G.-C., Lin, X.-R., & Chang, W.-H. (2003). Effects of patient demographics, risperidone dosage, and clinical outcome on body weight in acutely exacerbated schizophrenia. The Journal of Clinical Psychiatry, 64(3), 316–320. Liu YT, Chau YL, Hsu SC, Chu CL, Chen CY. Factors influencing weight gain in an Asian population of psychiatric inpatients: a retrospective study in Taiwan. Asia Pac Psychiatry. 2014 Jun;6(2):226-34. doi: 10.1111/j.1758-5872.2012.00223.x. Epub 2012 Jul 30. PMID: 23857729. Leonhart, R., & Lichtenberg, S. (2009). Lehrbuch Statistik. H. Huber. Locke, A. E., Kahali, B., Berndt, S. I., Justice, A. E., Pers, T. H., Day, F. R., Powell, C., Vedantam, S., Buchkovich, M. L., Yang, J., Croteau-Chonka, D. C., Esko, T., Fall, T., Ferreira, T., Gustafsson, S., Kutalik, Z., Luan, J., Mägi, R., Randall, J. C., … Speliotes, E. K. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518, 197. McElroy, S. L., Kotwal, R., Malhotra, S., Nelson, E. B., Keck, P. E., & Nemeroff, C. B. (2004). Are mood disorders and obesity related? A review for the mental health professional. The Journal of Clinical Psychiatry, 65(5), 634–651, quiz 730. Megna, J. L., Raj Kunwar, A., & Wade, M. J. (2006). A retrospective study of weight changes and the contributing factors in short term adult psychiatric inpatients. Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists, 18(3), 163–167. https://doi.org/10.1080/10401230600801168 Musil, R., Obermeier, M., Russ, P., & Hamerle, M. (2015). Weight gain and antipsychotics: A drug safety review. Expert Opinion on Drug Safety, 14(1), 73–96. https://doi.org/10.1517/14740338.2015.974549 Nasse, K. F. W. (1859). Allg Z Psychiatrie Psychisch-Gerichtliche Med 16. 541–602. Noordam, R., Aarts, N., Tiemeier, H., Hofman, A., Stricker, B. H., & Visser, L. E. (2015). Sex-specific association between antidepressant use and body weight in a population-based study in older adults. The Journal of Clinical Psychiatry, 76(6), e745-751. https://doi.org/10.4088/JCP.13m08896 Obesity Update—OECD. (o. J.). Abgerufen 4. Februar 2018, von http://www.oecd.org/health/obesity-update.htm Peet, M. (2004). Diet, diabetes and schizophrenia: Review and hypothesis. The British Journal of Psychiatry. Supplement, 47, S102-105. Safer, D. J. (2004). A comparison of risperidone-induced weight gain across the age span. Journal of Clinical Psychopharmacology, 24(4), 429–436. https://doi.org/10.1097/01.jcp.0000130558.86125.5b Schmidt, F. M., Lichtblau, N., Minkwitz, J., Chittka, T., Thormann, J., Kirkby, K. C., Sander, C., Mergl, R., Faßhauer, M., Stumvoll, M., Holdt, L. M., Teupser, D., Hegerl, U., & Himmerich, H. (2014). Cytokine levels in depressed and non-depressed subjects, and masking effects of obesity. Journal of Psychiatric Research, 55, 29–34. https://doi.org/10.1016/j.jpsychires.2014.04.021 Schoretsanitis, G., Drukker, M., Van Os, J., Schruers, K. R. J., & Bak, M. (2018). No differences in olanzapine- and risperidone-related weight gain between women and men: A meta-analysis of short- and middle-term treatment. Acta Psychiatrica Scandinavica. https://doi.org/10.1111/acps.12879 Schwartz, E., Charlotte, M., Slade, E., Medoff, D., Li, L., Dixon, L., Kilbourne, A., & Kreyenbuhl, J. (2015). Gender differences in antipsychotics prescribed to veterans with serious mental illness. General Hospital Psychiatry, 37(4), 347–351. https://doi.org/10.1016/j.genhosppsych.2015.03.018 Seeman, M. V. (2009). Secondary effects of antipsychotics: Women at greater risk than men. Schizophrenia Bulletin, 35(5), 937–948. https://doi.org/10.1093/schbul/sbn023 Sellayah, D., Cagampang, F. R., & Cox, R. D. (2014). On the evolutionary origins of obesity: A new hypothesis. Endocrinology, 155(5), 1573–1588. https://doi.org/10.1210/en.2013-2103 Serretti, A., & Mandelli, L. (2010). Antidepressants and Body Weight: A Comprehensive Review and Meta-Analysis. The Journal of Clinical Psychiatry, 71(10), 1259–1272. https://doi.org/10.4088/JCP.09r05346blu Shin, J. K., Barron, C. T., Chiu, Y.-L., Jang, S. H., Touhid, S., & Bang, H. (2012). Weight changes and characteristics of patients associated with weight gain during inpatient psychiatric treatment. Issues in Mental Health Nursing, 33(8), 505–512. https://doi.org/10.3109/01612840.2012.683931 Speakman, J. R. (2008). Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: The „drifty gene“ hypothesis. International Journal of Obesity (2005), 32(11), 1611–1617. https://doi.org/10.1038/ijo.2008.161 Stauffer, V. L., Sniadecki, J. L., Piezer, K. W., Gatz, J., Kollack-Walker, S., Hoffmann, V. P., Conley, R., & Durell, T. (2010). Impact of race on efficacy and safety during treatment with olanzapine in schizophrenia, schizophreniform or schizoaffective disorder. BMC Psychiatry, 10, 89. https://doi.org/10.1186/1471-244X-10-89 Stryjecki, C., Alyass, A., & Meyre, D. (2018). Ethnic and population differences in the genetic predisposition to human obesity. Obesity Reviews: An Official Journal of the International Association for the Study of Obesity, 19(1), 62–80. https://doi.org/10.1111/obr.12604 Sušilová, L., Češková, E., Hampel, D., Sušil, A., & Šimůnek, J. (2017). Changes in BMI in hospitalized patients during treatment with antipsychotics, depending on gender and other factors. International Journal of Psychiatry in Clinical Practice, 21(2), 112–117. https://doi.org/10.1080/13651501.2017.1291818 Thakore, J. H., Mann, J. N., Vlahos, I., Martin, A., & Reznek, R. (2002). Increased visceral fat distribution in drug-naive and drug-free patients with schizophrenia. International Journal of Obesity and Related Metabolic Disorders: Journal of the International Association for the Study of Obesity, 26(1), 137–141. https://doi.org/10.1038/sj.ijo.0801840 Uher, R., Farmer, A., Henigsberg, N., Rietschel, M., Mors, O., Maier, W., Kozel, D., Hauser, J., Souery, D., Placentino, A., Strohmaier, J., Perroud, N., Zobel, A., Rajewska-Rager, A., Dernovsek, M. Z., Larsen, E. R., Kalember, P., Giovannini, C., Barreto, M., … Aitchison, K. J. (2009). Adverse reactions to antidepressants. British Journal of Psychiatry, 195(3), 202–210. https://doi.org/10.1192/bjp.bp.108.061960 Verbrugge, L. M. (1982). Sex differentials in health. Public Health Reports (Washington, D.C.: 1974), 97(5), 417–437. Wang, Y., & Beydoun, M. A. (2007). The obesity epidemic in the United States--gender, age, socioeconomic, racial/ethnic, and geographic characteristics: A systematic review and meta-regression analysis. Epidemiologic Reviews, 29, 6–28. https://doi.org/10.1093/epirev/mxm007 WHO Expert Consultation. (2004). Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet (London, England), 363(9403), 157–163. https://doi.org/10.1016/S0140-6736(03)15268-3 Wiener, H. (2008). Pharmakokinetische und pharmakodynamische Unterschiede zwischen den Geschlechtern. Journal für Hypertonie - Austrian Journal of Hypertension, 12 (2), 22–25. | |||||||
Lizenz: | ![]() Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
Bezug: | Datenerhebung zwischen Mai 2003 und Juni 2006 in Deutschland (Düsseldorf und Ulm/Günzburg), Dänemark, Schweiz, Nigeria und Japan | |||||||
Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
Dokument erstellt am: | 08.03.2024 | |||||||
Dateien geändert am: | 08.03.2024 | |||||||
Promotionsantrag am: | 10.03.2023 | |||||||
Datum der Promotion: | 05.12.2023 |