Dokument: Enantioselective Gold-Catalyzed Desymmetrization of 1,4-Diyne Species and Its Application on Naturally Occurring Compound Synthesis
| Titel: | Enantioselective Gold-Catalyzed Desymmetrization of 1,4-Diyne Species and Its Application on Naturally Occurring Compound Synthesis | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=64737 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20240301-114038-2 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | Yu, Jhen-Kuei [Autor] | |||||||
| Dateien: |
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| Beitragende: | Prof. Dr. Czekelius, Constantin [Gutachter] Prof. Dr. Pietruszka, Jörg [Gutachter] | |||||||
| Dewey Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik » 540 Chemie | |||||||
| Beschreibung: | In this dissertation, an extensive application of 1,4-diyne substrates featuring quaternary centers in synthetic chemistry has been demonstrated. It begins by describing the preparation and functionalization of these substrates, highlighting their unique chemical properties. With readily available 1,4-diyne substrates prepared using self-developed methodology, their reactivity in the presence of cationic gold complexes is investigated.
Various gold-catalyzed intramolecular cyclic functionalizations on the alkyne group are explored, both in chiral and achiral fashion, including alkyne hydroxylation (Chapter 2), enyne isomerization (Chapter 3), and alkyne hydroamination (Chapter 4). These investigations not only provide insights into the mild gold-catalyzed cyclization of diverse substrates but also shed light on the mechanistic details of the processes. Furthermore, based on the knowledge and success gained from the enantioselective intramolecular hydroamination, the dissertation describes a diversity-oriented formal total synthesis of a wide range of naturally occurring compounds in the Amaryllidaceae family (Chapter 4). This work showcases the exploration of novel chemical substrates and provides mechanistic insights while facilitating the synthesis of these valuable natural products. | |||||||
| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät » WE Chemie » Organische Chemie und Makromolekulare Chemie | |||||||
| Dokument erstellt am: | 01.03.2024 | |||||||
| Dateien geändert am: | 01.03.2024 | |||||||
| Promotionsantrag am: | 31.08.2023 | |||||||
| Datum der Promotion: | 24.10.2023 |
