Dokument: Die Auswirkungen von kaltem, atmosphärischem Plasma auf die Durchblutung
| Titel: | Die Auswirkungen von kaltem, atmosphärischem Plasma auf die Durchblutung | |||||||
| Weiterer Titel: | The effects of cold atmospheric plasma on blood circulation | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=64406 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20231213-074441-5 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Deutsch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | Wurth, Michael [Autor] | |||||||
| Dateien: |
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| Beitragende: | Prof. Dr. rer. nat. Suschek, Christoph Viktor [Gutachter] Priv.-Doz. Dr. rer. nat. Mahotka, Czaba [Gutachter] | |||||||
| Dewey Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit | |||||||
| Beschreibungen: | Chronische Wunden, stellen vor allem im Rahmen zunehmender, zivilisatorischer Erkrankungen, wie die pAVK oder der Diabetes mellitus, ein großes Problem für die Betroffenen dar, welche mit einer deutlichen Reduktion der Lebensqualität einhergeht. Des Weiteren sind sie auch eine enorme Belastung für die Ressourcen unseres Gesundheitssystems. Neue Behandlungsmethoden, welche einfach, kostengünstig und effektiv sind, sind daher aktuell notwendiger denn je. Eine alternativeTherapieoption, wäre die Anwendung von kaltem, atmosphärischem Plasma, welchesein ionisiertes und elektrisch leitendes Gas darstellt und bei Raumtemperatur erzeugtwerden kann und reaktive Sauerstoffspezies und Stickstoffmonoxid und dessen Derivate produzieren kann. Diese wiederum sind wichtige Mediatoren bei Wundheilungsprozessen und nehmen Einfluss auf die Durchblutung und Immunreaktionen. Diese Arbeit beschäftigt sich vorrangig damit, ob Einflüsse auf die Durchblutung durch Anwendung direkten, kalten Plasmas vorhanden sind und ob diese durch verschiedene Einflussfaktoren wie Feuchtigkeit der Haut, erzeugte UV- Strahlung, (welche bei Plasmagenerierung anfällt) Anwendungsdauer der Plasmabehandlung oder durch Druck auf die Behandlungsstelle beeinflusst werden kann. Hierbei wurde eine direkte, atmosphärische DBD (dielectric-barrier-discharge) Plasmaquelle verwendet, welche über ein Handgerät verfügt, welches das Plasma direkt auf die Behandlungsstelle bringen kann. Die Durchblutungsparameter wie die relative Sauerstoffsättigung, relative Hämoglobinmenge, relativer Blutfluss und Blutflussgeschwindigkeit wurde durch Laser-Doppel-Spektroskopie in oberflächlichen und tiefen Hautschichten an derBehandlungsstelle erfasst. Hierfür wurde ein O2C-Gerät der Firma „LEA-Medizin- Technik-Gießen“ verwendet, welche die Parameter durch Auflegen einer fiberoptischen Glassonde direkt erfassen kann. Insgesamt wurden 24 Probanden einer Plasmabehandlung unterzogen, aufgeteilt auf verschiedene Behandlungszeiten. Die Durchblutungsparameter wurden unter standardisieren Bedingungen erfasst, um Störfaktoren möglich gering zu halten. Es wurden mehrere Referenzmessungen vor der Behandlung durchgeführt und unmittelbar nach der Plasmabehandlung in regelmäßigen zeitlichen Abständen die Parameter protokolliert.
In meiner Arbeit konnte kein signifikanter Effekt auf die Durchblutung, sowohl in oberflächlichen, als auch in tieferen Hautschichten nachgewiesen werden. Auch eine Erhöhung der Behandlungszeit auf 360s änderte daran nichts. Mögliche effektsteigernde oder effektsenkende Einflüsse, wie die Feuchtigkeit der Haut, oder UV- Strahlung nahmen ebenfalls keinen signifikanten Einfluss darauf.Chronic wounds, especially in the context of increasing civilizational diseases, such as PAD or diabetes mellitus, represent a major problem for those affected, which is accompanied by a significant reduction in quality of life. Furthermore, they are also an enormous burden on the resources of our health system. New treatment methods that are simple, cost-effective and effective are therefore currently more necessary than ever. An alternative therapy option would be the application of cold, atmospheric plasma, which is an ionized and electrically conductive gas and can be generated at room temperature and can produce reactive oxygen species and nitric oxide and its derivatives. These in turn are important mediators in wound healing processes and influence blood circulation and immune reactions. This thesis is primarily concerned with whether influences on blood circulation are present through the application of direct, cold plasma and whether this can be influenced by various influencing factors such as moisture of the skin, UV radiation generated, (which occurs during plasma generation) application period of the plasma treatment, or pressure generated by the handheld device on the treatment site. A direct, atmospheric DBD (dielectric-barrier-discharge) plasma source was used, which has a handheld device that can deliver the plasma directly to the treatment site.The blood flow parameters such as relative oxygen saturation, relative hemoglobin amount, relative blood flow and blood flow velocity were recorded by laser double spectroscopy in superficial and deep skin layers at the treatment site. For this purpose, an O2C device from the company "LEA-Medizin-Technik-Gießen" was used, which can directly record the parameters by placing a fiber-optic glass probe. A total of 24 subjects underwent plasma treatment, divided into different treatment times. The blood flow parameters were recorded under standardized conditions in order to keep disturbing factors as low as possible. Several reference measurements were carried out before the treatment and the parameters were logged at regular intervals immediately after the plasma treatment. In my work, no significant effect on blood circulation could be detected, both in superficial and deeper skin layers. Even increasing the treatment time to 360s did not change this.Possible effect-enhancing or effect-reducing influences, such as the moisture of the skin, or UV radiation also had no significant influence on this. | |||||||
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| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 13.12.2023 | |||||||
| Dateien geändert am: | 13.12.2023 | |||||||
| Promotionsantrag am: | 25.06.2013 | |||||||
| Datum der Promotion: | 22.08.2023 |
