Dokument: Zytoarchitektonische Parzellierung und funktionelle Charakterisierung vier neuer Areale im kaudalen parahippocampalen Kortex
| Titel: | Zytoarchitektonische Parzellierung und funktionelle Charakterisierung vier neuer Areale im kaudalen parahippocampalen Kortex | |||||||
| Weiterer Titel: | Cytoarchitectonic parcellation and functional characterization of four new areas in the caudal parahippocampal cortex | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=63651 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20230920-110648-0 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Deutsch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | Stenger, Sophie Marie [Autor] | |||||||
| Dateien: |
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| Beitragende: | Prof. Dr. med. Amunts, Katrin [Gutachter] Prof. Dr.med. Dr.rer.pol. Caspers, Svenja [Gutachter] | |||||||
| Stichwörter: | Zytoarchitektur, Human brain mapping, Gyrus parahippocampalis, Sulcus collateralis, parahippocampal place area, Julich-Brain | |||||||
| Dewey Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit | |||||||
| Beschreibungen: | Der kaudale parahippocampale Kortex (PHC) ist im ventralen temporalen Kortex und am Übergang zum okzipitalen Kortex lokalisiert. Hirnareale dieser Region sind mit verschiedenen Funktionen assoziiert. Hierzu zählen insbesondere die Verarbeitung visuell-räumlicher Informationen und das episodische Gedächtnis. Eine entsprechend differenzierte funktionelle Parzellierung des PHC ergibt sich aus den Ergebnissen verschiedener Neuroimaging-Studien. Die mikrostrukturellen Korrelate dieser unterschiedlichen Funktionen sind bisher jedoch weniger gut verstanden und historische zytoarchitektonische Karten bilden die funktionelle Heterogenität dieser Region nicht adäquat ab. Aus diesem Grund befasst sich diese Arbeit mit der Untersuchung der zytoarchitektonischen Parzellierung des Gyrus parahippocampalis und des Sulcus collateralis als mögliche Korrelate für die vielfältigen Funktionen dieser Hirnregion. Hierzu wurden Serien histologischer Hirnschnitte von zehn postmortalen humanen Gehirnen mithilfe einer beobachterunabhängigen Kartierungsmethode untersucht. Dabei wurden vier neue zytoarchitektonische Hirnareale - Ph1, Ph2, Ph3 und CoS1 - im Gyrus parahippocampalis und im Sulcus collateralis der zehn Gehirne identifiziert und kartiert, auf zwei Standardreferenzräume registriert und überlagert. Es wurden Wahrscheinlichkeitskarten berechnet, die die interindividuelle Variabilität zwischen den Gehirnen berücksichtigen. Darüber hinaus wurden diese Wahrscheinlichkeitskarten mit Daten funktioneller Neuroimaging-Studien verglichen. Dieser Vergleich ergab ein differenziertes Aktivierungsmuster innerhalb der vier neuen Areale für eine Vielzahl von Funktionen, die insbesondere die Verarbeitung visuell-räumlicher Informationen und das assoziative Gedächtnis betrafen. Die Karten sind über den Julich-Brain Atlas frei zugänglich. Sie können genutzt werden, um Informationen anderen Modalitäten, wie Netzwerke, genetische Expressionsmuster oder funktionelle Neuroimaging-Daten, mit dieser Region in Beziehung zu setzen. In diesem Zusammenhang können sie als anatomische Referenz dienen und zu einem besseren Verständnis der Beziehungen zwischen Struktur und Funktion des kaudalen parahippocampalen Kortex beitragen.The caudal parahippocampal cortex (PHC) is localized in the ventral temporal cortex and the transition to the occipital cortex. Brain areas of this region are associated with various functions. These include, in particular, the processing of visuo-spatial information and episodic memory. A correspondingly differentiated functional parcellation of the PHC results from findings of various neuroimaging studies. However, the microstructural correlates of these different functions have been less well understood so far and historical cytoarchitectonic maps do not adequately depict the functional heterogeneity of this region. For this reason, this work aimed to study the cytoarchitectural parcellation of the parahippocampal gyrus and the sulcus collateralis as putative correlates for the multifaceted functions of this brain region. For this purpose, series of histological brain sections from ten postmortem human brains were examined based on observer-independent mapping. Four new cytoarchitectonic brain areas – Ph1, Ph2, Ph3 and CoS1 – were identified and mapped in the parahippocampal gyrus and the collateral sulcus of ten brains, registered to two standard reference spaces, and superimposed. Probability maps were calculated, taking into account interindividual variability between brains. In addition, these probability maps were compared with data from functional neuroimaging studies. This comparison revealed a differentiated activation pattern within the four new areas for a variety of functions, which particularly concerned the processing of visuo-spatial information and associative memory. The maps are openly available in the Julich-Brain atlas. These maps are a beneficial tool to relate information from other modalities, such as networks, genetic expression patterns or functional neuroimaging, with this region. In this context, they can serve as an anatomical reference and contribute to a better understanding of the relationships between structure and function of the caudal parahippocampal cortex. | |||||||
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| Lizenz: |  Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät » Institute » C. u. O. Vogt-Institut für Hirnforschung | |||||||
| Dokument erstellt am: | 20.09.2023 | |||||||
| Dateien geändert am: | 20.09.2023 | |||||||
| Promotionsantrag am: | 28.01.2023 | |||||||
| Datum der Promotion: | 29.08.2023 |
