Dokument: The effect modification by the Mediterranean Diet (MeDi) on skin aging in elderly women exposed to air pollution

Titel:	The effect modification by the Mediterranean Diet (MeDi) on skin aging in elderly women exposed to air pollution
Weiterer Titel:	Die Effekt Modifizierung der mediterranen Diät (MeDi) auf die Hautalterung älterer Frauen die der Luftverschmutzung ausgesetzt sind
URL für Lesezeichen:	https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=58485
URN (NBN):	urn:nbn:de:hbz:061-20220117-082747-6
Kollektion:	Dissertationen
Sprache:	Englisch
Dokumententyp:	Wissenschaftliche Abschlussarbeiten » Dissertation
Medientyp:	Text
Autor:	Stender, Vanessa [Autor]
Dateien:	[Dateien anzeigen] Adobe PDF [Details] 3,21 MB in einer Datei [ZIP-Datei erzeugen] Dateien vom 05.01.2022 / geändert 05.01.2022
Beitragende:	Schikowski, Tamara [Gutachter] Prof. Dr. Jean Krutmann [Gutachter] Prof. Dr. Dragano, Nico [Gutachter] Haarmann-Stemmann, Thomas [Gutachter]
Stichwörter:	Mediteranean diet, skin aging, air pollution
Dewey Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit
Beschreibungen:	Einleitung: Seit Jahrzehnten ist bekannt, dass UV-Strahlung und Rauchen extrinsische Hautalterung verursachen können. Aber auch Luftverschmutzung hat einen Einfluss auf die Hautalterung, insbesondere auf die Bildung von Falten und Pigmentflecken. Dies konnte zuerst in der SALIA Studie (Study on the influence of air pollution on lung function, inflammation and aging) gezeigt werden. Ernährung ist ein weiterer Faktor, der zur Hautgesundheit beiträgt. Der Aufnahme von Antioxidantien in Form von Obst und Gemüse sowie der Kalorien Restriktion wird nachgesagt, der Alterung entgegenzuwirken. Belege dafür sind allerdings kaum vorhanden. Methoden: In der vorliegenden Arbeit wurde der Zusammenhang zwischen Hautalterung und mediterraner Ernährung bei 807 kaukasischen Frauen der SALIA Kohorte angeschaut. Dafür wurden Ergebnisse eines Fragebogens und eines erstellten MEDI Score basierend auf dem Score von Panagiotakos benutzt. Die Hautalterung wurde durch den SCINEXATM Score beurteilt. Die Luftverschmutzung (NO2, PM10, PM2.5, PM2.5coarse, O3) wurde anhand von Land-Nutzungs-Modellen bestimmt und anhand der Wohnadresse den einzelnen Probanden zugewiesen. Für die Statistik nutzten wir multiple logistische Regressionsmodelle, bezogen eine Interaktionsvariable (MEDI Score und Luftverschmutzungsparameter) ein und adjustierten für Kovariablen (Stadt oder Land, Sozialstatus, Alter, BMI, „Packyears“, Raucherstatus, Heizen mit fossilen Brennstoffen, Hauttyp, Lichtschutzfaktor, UV-Strahlung, Hormonersatztherapie, Sonnenbanknutzung). Ergebnisse: Höhere Belastungen mit NO2 korrelierten signifikant mit der Bildung von Pigmentflecken (Z-Scores). Höhere PM10 und PM2.5 Werte waren signifikant assoziiert mit der Bildung von Falten auf der Oberlippe, ebenso mit der gleichmäßigen Pigmentierung auf der Unterarminnenseite. In den Modellen ohne Adjustierung für die UV Variablen korrelierten NO2 und Ruß signifikant mit der Bildung von Nasolabialfalten. Der MEDI Score zeigte einzig einen schützenden Effekt für zigarettenpapierartige Fältelung auf dem Handrücken. Für viele andere Hautalterungsparameter zeigte der MEDI einen schädigenden Effekt. Der Antioxidantien Score zeigte nur für Pigmentflecken auf der Stirn einen schützenden Effekt. Die Interaktionsvariablen MEDI und PM10, genauso wie MEDI und PM2.5 zeigten eine schützende Tendenz auf die Faltenbildung (z-score). Diskussion: Es gibt keine Zweifel daran, dass Luftverschmutzung negativ auf die Hautalterung wirkt. Antioxidantien und gute Ernährung sind weit verbreitete Verjüngungsmethoden. Die Studien dazu widersprechen sich allerdings, zeigen nur kleine Effekte und klinische Daten die die sichtbaren Effekte belegen fehlen bislang. Durch diese Studie versuchten wir Klarheit zu schaffen, allerdings bleiben Zweifel daran ob Ernährung überhaupt einen Einfluss auf die Hautalterung hat. Introduction: For decades extrinsic skin aging is known as the result of UV radiation and smoking, but also air pollution has an impact on skin aging, presenting itself in wrinkle formation and pigment spots. This has been shown in the SALIA study (Study on the influence of air pollution on lung function, inflammation and aging) for the first time. Nutrition is a further factor contributing to skin health. Antioxidant uptake through fruits and vegetables as well as calorie restriction is rumored to delay aging effects. However, the evidence is very scarce. Methods: We assessed the association of skin aging with an adherence to the Mediterranean diet (MEDI) in 807 Caucasian women from the SALIA cohort study using results of a questionnaire and transforming them to a MEDI score based on the score of Panagiotakos. Skin aging was evaluated by the SCINEXA score. Air pollution (NO2, PM10, PM2.5, PM2.5 coarse, O3) was evaluated by land use regression models and assigned to the home address of the study subjects. We applied multiple logistic regression models, included an interaction variable (MEDI score and air pollutant) and adjusted for covariates (urban or rural, social status, age, BMI, packyears, smoking status, heating with fossil fuels, skin type, sun protection factor, UV radiation, hormone replacement therapy, sunbed use). Results: Higher NO2 exposure was significantly associated with the formation of pigment spots in general (z-scores). Higher PM10 and PM2.5 values were significantly associated with the formation of wrinkles on the upper lip as well as the even pigmentation on the forearm inside. In models without adjustment for UV covariates NO2 and PM2.5absorbance correlated significantly with the formation of nasolabialfolds. The MEDI score showed a protective effect on cigarette paper like skin on the back of the hands. For many other skin aging parameters the MEDI score presented a harmful correlation. The antioxidant score showed a protective effect on pigment spots on the forehead only. The interaction terms MEDI and PM10 as well as MEDI and PM2.5 showed a protective tendency on the wrinkle formation (z-score). Discussion: There is no doubt that air pollution has a negative impact on skin aging. Antioxidants and healthy nutrition is broadly promoted as a rejuvenation method, but the studies contradict each other, or just show small effects and clinical data showing a visible effect are missing. In this study we tried to get clarity, but there is still remaining doubts if nutrition has an impact on skin aging at all.
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Lizenz:	Urheberrechtsschutz
Fachbereich / Einrichtung:	Zentrale Einrichtungen » Universitäts- und Landesbibliothek (ULB)
Dokument erstellt am:	17.01.2022
Dateien geändert am:	17.01.2022
Promotionsantrag am:	12.04.2021
Datum der Promotion:	30.11.2021