Dokument: Delayed viral propagation during initial phase of infection leads to viral persistence
| Titel: | Delayed viral propagation during initial phase of infection leads to viral persistence | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=55013 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20211229-085818-8 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | Dr.rer.nat. Wang, Ruifeng [Autor] | |||||||
| Dateien: |
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| Beitragende: | Prof. Dr. med. Lang, Philipp [Gutachter] Prof. Dr. Schaal, Heiner [Gutachter] | |||||||
| Stichwörter: | Biology | |||||||
| Dewey Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik » 570 Biowissenschaften; Biologie | |||||||
| Beschreibung: | LCMV genome consists of two single-stranded RNA segments, L and S, which use an ambisense coding strategy to complete the viral RNA replication and protein translation. The S segment encodes the structural proteins: nucleoprotein (NP), and two glycoproteins, GP-1 and GP-2. The L segment directs the synthesis of the viral polymerase L and a small polypeptide Z. The viral RNA associated with the NP protein and the viral polymerase composes the viral ribonucleoprotein (RNP), which is the minimal infectious unit. Different proteins have distinct functions during viral infection. However, different point mutations in the proteins of LCMV result in the formation of acute and chronic infection,
Thus, we focus on two different strains of LCMV, WE and Docile, which are able to induce acute and chronic infection, respectively. We found that WE induced much more IFNα production and CTL expansion, while Docile did less so. Additionally, viral replication is faster in WE infected mice and APCs at early time points. Furthermore, we have shown that viral entry is faster during infection with LCMV WE. These findings indicate that delayed viral entry and viral replication during the initial phase of infection leads to viral persistence. | |||||||
| Lizenz: |  Urheberrechtsschutz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät » Institute » Institut für Molekulare Medizin | |||||||
| Dokument erstellt am: | 29.12.2021 | |||||||
| Dateien geändert am: | 29.12.2021 | |||||||
| Promotionsantrag am: | 15.10.2020 | |||||||
| Datum der Promotion: | 09.12.2020 |
