Dokument: Beeinträchtigte taktile zeitliche Diskrimination bei Patienten mit hepatischer Enzephalopathie
| Titel: | Beeinträchtigte taktile zeitliche Diskrimination bei Patienten mit hepatischer Enzephalopathie | |||||||
| Weiterer Titel: | Impaired Tactile Temporal Discrimination in Patients With Hepatic Encephalopathy | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=54401 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20201013-112204-0 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Deutsch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | Lazar, Moritz [Autor] | |||||||
| Dateien: |
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| Beitragende: | Prof. Dr. Schnitzler, Alfons [Gutachter] Prof. Dr. Seitz, Rüdiger [Gutachter] | |||||||
| Dewey Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit | |||||||
| Beschreibungen: | Das sensorische System erhält und verarbeitet kontinuierlich Stimuli aus der
Umwelt. Um zwei einzelne Stimuli als zeitlich getrennte Ereignisse unterscheiden zu können, muss die zeitliche Distanz, d. h. die Asynchronität der Stimuli (stimulus onset asynchrony, SOA) eine bestimmte Dauer überschreiten. Wenn zwei Stimuli diese zeitliche Reizschwelle unterschreiten, werden sie als ein einzelnes, gemeinsames Ereignis interpretiert. Für Patienten mit hepatischer Enzephalopathie (HE) wurden in der Vergangenheit bereits verschiedene Einschränkungen sensorischer Qualitäten beschrieben wie z. B. eine verlangsamte visuelle zeitliche Diskrimination mittels der sogenannten kritischen Flimmerfrequenz (critical flicker frequency, CFF). Die vorliegende Arbeit untersuchte nun die taktile zeitliche Diskriminationsfähigkeit von Patienten mit HE unter der Annahme, dass diese Patientengruppe längere SOAs benötigt, um zwei Stimuli als zeitlich getrennte Ereignisse wahrnehmen zu können. Um diese Hypothese zu überprüfen, wurden Patienten mit unterschiedlichen Schweregraden der HE sowie altersentsprechende, gesunde Probanden einem taktilen zeitlichen Diskriminationstest unterzogen. Alle Teilnehmer erhielten mehrfach zwei taktile Stimuli mit unterschiedlichen SOAs, die über Ringelektroden am linken Zeigefinger appliziert wurden. Nach jeder Stimulation sollten die Probanden berichten, ob sie 1 oder 2 Stimuli wahrgenommen hatten. Es zeigte sich, dass HE Patienten einen signifikant längeren SOA (Median: 154,4 ms, erstes Quartil: 103,5 ms, drittes Quartil: 169,3 ms) benötigten, um zwei Stimuli als getrennte Ereignisse wahrnehmen zu können als gesunde Probanden gleichen Alters (Median: 96,8 ms, erstes Quartil: 31,4 ms, drittes Quartil: 124,1 ms, p < 0,01). Darüber hinaus konnte gezeigt werden, dass die Fähigkeit zur zeitlichen, taktilen Diskrimination negativ mit der Fähigkeit zur zeitlichen visuellen Diskrimination korrelierte (r = -0,37, p = 0,033). Diese Ergebnisse zeigen, dass die taktile zeitliche Diskrimination bei Patienten mit HE beeinträchtigt ist. Darüber hinaus deuten sie darauf hin, dass taktile und visuelle Einschränkungen HE Patienten in ähnlicher Weise betreffen. Dies könnte für einen gemeinsamen zugrundeliegenden, pathophysiologischen Schlüssel- Mechanismus sprechen. Ein solcher Mechanismus könnte die postulierte, globale Verlangsamung neuronaler Oszillationen bei HE Patienten sein.The sensory system continuously receives and processes stimuli from the external world. To discriminate two stimuli as two temporally separated events the temporal distance between those stimuli or the stimulus onset asynchrony (SOA) needs to exceed a certain threshold. If the SOA is shorter than the specific threshold, two stimuli will be perceived as one single event. It is known that patients with hepatic encephalopathy (HE) present a broad variety of neuropsychiatric symptoms, e.g. impairments of the sensory modality. The deterioration of the visual temporal discrimination ability can be measured by the critical flicker frequency (CFF). In the present work, the tactile temporal discrimination of patients with HE is analyzed, assuming that longer SOAs are needed to perceive two stimuli as temporally separated events. To test this hypothesis patients with varying grades of HE and age-matched healthy controls performed a tactile temporal discrimination task. All participants received multiple pairs of tactile stimuli with varying SOAs, applied by ringelectrodes to the left index finger. After each stimulation participants reported whether they perceived the simulation as 1 or 2 separate stimuli. HE patients needed a significantly longer SOA (median: 154.4 ms, first quartile: 103.5 ms, third quartile: 169.3 ms) to discriminate between two stimuli in comparison to healthy individuals (median: 96.8 ms, first quartile: 31.4 ms, third quartile: 124.1 ms, p < 0.01). In addition, it was shown that the tactile temporal discrimination ability correlates negatively with the visual temporal discrimination ability (r = -0.37, p = 0.033). The present results provide evidence that the tactile temporal discrimination is substantially impaired in patients with HE. Furthermore, the findings indicate that both the tactile temporal discrimination ability as well as the visual temporal discrimination ability in HE patients deteriorate in parallel. This outcome argues for a common underlying pathophysiological key mechanism. Such a mechanism can be represented by the known global slowing of neuronal oscillations in patients with HE. | |||||||
| Quelle: | AGARWAL, R. & BAID, R. 2016. Asterixis. J Postgrad Med, 62, 115-7.
AHBOUCHA, S. 2011. Neurosteroids and hepatic encephalopathy: an update on possible pathophysiologic mechanisms. Curr Mol Pharmacol, 4, 1-13. AMER, K., HASHIM, M. S., ABD EL SAMEEA, E., OBADA, M., EL HELBAWY, M. G., EDREES, A., SALMAN, T. A., AL HADDAD, O. & SALAMA, M. 2013. Evaluation of rifaximin in Egyptian patients with hepatic encephalopathy. Egyptian Liver Journal, 3, 113-117. AMODIO, P. & GATTA, A. 2005. Neurophysiological investigation of hepatic encephalopathy. Metab Brain Dis, 20, 369-79. ANTELMI, E., ERRO, R., ROCCHI, L., LIGUORI, R., TINAZZI, M., DI STASIO, F., BERARDELLI, A., ROTHWELL, J. C. & BHATIA, K. P. 2017. Neurophysiological correlates of abnormal somatosensory temporal discrimination in dystonia. Mov Disord, 32, 141-148. ARTIEDA, J., MURUZABAL, J., LARUMBE, R., GARCIA DE CASASOLA, C. & OBESO, J. A. 1992. Cortical mechanisms mediating asterixis. Mov Disord, 7, 209-16. BAJAJ, J. S., SCHUBERT, C. M., HEUMAN, D. M., WADE, J. B., GIBSON, D. P., TOPAZ, A., SAEIAN, K., HAFEEZULLAH, M., BELL, D. E., STERLING, R. K., STRAVITZ, R. T., LUKETIC, V., WHITE, M. B. & SANYAL, A. J. 2010. Persistence of cognitive impairment after resolution of overt hepatic encephalopathy. Gastroenterology, 138, 2332-40. BAJAJ, J. S., WADE, J. B. & SANYAL, A. J. 2009. Spectrum of neurocognitive impairment in cirrhosis: Implications for the assessment of hepatic encephalopathy. Hepatology, 50, 2014-21. BAUMGARTEN, T. J., KONIGS, S., SCHNITZLER, A. & LANGE, J. 2017a. Subliminal stimuli modulate somatosensory perception rhythmically and provide evidence for discrete perception. Sci Rep, 7, 43937. BAUMGARTEN, T. J., NEUGEBAUER, J., OELTZSCHNER, G., FULLENBACH, N. D., KIRCHEIS, G., HAUSSINGER, D., LANGE, J., WITTSACK, H. J., BUTZ, M. & SCHNITZLER, A. 2018. Connecting occipital alpha band peak frequency, visual temporal resolution, and occipital GABA levels in healthy participants and hepatic encephalopathy patients. Neuroimage Clin, 20, 347-356. BAUMGARTEN, T. J., SCHNITZLER, A. & LANGE, J. 2015. Beta oscillations define discrete perceptual cycles in the somatosensory domain. Proc Natl Acad Sci U S A, 112, 12187-92. BAUMGARTEN, T. J., SCHNITZLER, A. & LANGE, J. 2016. Prestimulus Alpha Power Influences Tactile Temporal Perceptual Discrimination and Confidence in Decisions. Cereb Cortex, 26, 891-903. BAUMGARTEN, T. J., SCHNITZLER, A. & LANGE, J. 2017b. Beyond the Peak - Tactile Temporal Discrimination Does Not Correlate with Individual Peak Frequencies in Somatosensory Cortex. Front Psychol, 8, 421. BAUMGARTEN, T. J. L., M.; FÜLLENBACH, N.-D.; JÖRDENS, M. S.; HÄUSSINGER, D.; SCHNITZLER, A.; LANGE, J. Neuronal oscillatory activity and temporal perception in the tactile domain - Alterations in hepatic encephalopathy. Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2019 Chicago. BERGER, H. 1929. Über das Elektroenkephalogramm des Menschen. Archiv für Psychiatrie und Nervenkrankheiten, 87, 527-570. 4. Literaturverzeichnis 33 BICKFORD, R. G. & BUTT, H. R. 1955. Hepatic coma: the electroencephalographic pattern. J Clin Invest, 34, 790-9. BLAUENFELDT, R. A., OLESEN, S. S., HANSEN, J. B., GRAVERSEN, C. & DREWES, A. M. 2010. Abnormal brain processing in hepatic encephalopathy: evidence of cerebral reorganization? Eur J Gastroenterol Hepatol, 22, 1323-30. BRADLEY, D., WHELAN, R., KIMMICH, O., O'RIORDAN, S., MULROONEY, N., BRADY, P., WALSH, R., REILLY, R. B., HUTCHINSON, S., MOLLOY, F. & HUTCHINSON, M. 2012. Temporal discrimination thresholds in adult-onset primary torsion dystonia: an analysis by task type and by dystonia phenotype. J Neurol, 259, 77-82. BRENNER, M., BUTZ, M., MAY, E. S., KAHLBROCK, N., KIRCHEIS, G., HAUSSINGER, D. & SCHNITZLER, A. 2015. Patients with manifest hepatic encephalopathy can reveal impaired thermal perception. Acta Neurol Scand, 132, 156-63. BROWN, P. 2003. Oscillatory nature of human basal ganglia activity: relationship to the pathophysiology of Parkinson's disease. Mov Disord, 18, 357-63. BUSCH, N. A., DUBOIS, J. & VANRULLEN, R. 2009. The phase of ongoing EEG oscillations predicts visual perception. J Neurosci, 29, 7869-76. BUTTERWORTH, R. F. 2019. Hepatic Encephalopathy in Cirrhosis: Pathology and Pathophysiology. Drugs, 79, 17-21. BUTZ, M., MAY, E. S., HAUSSINGER, D. & SCHNITZLER, A. 2013. The slowed brain: cortical oscillatory activity in hepatic encephalopathy. Arch Biochem Biophys, 536, 197-203. BUTZ, M., TIMMERMANN, L., GROSS, J., POLLOK, B., SUDMEYER, M., KIRCHEIS, G., HAUSSINGER, D. & SCHNITZLER, A. 2014. Cortical activation associated with asterixis in manifest hepatic encephalopathy. Acta Neurol Scand, 130, 260-7. BUZSAKI, G. & DRAGUHN, A. 2004. Neuronal oscillations in cortical networks. Science, 304, 1926-9. BUZSAKI, G., LOGOTHETIS, N. & SINGER, W. 2013. Scaling brain size, keeping timing: evolutionary preservation of brain rhythms. Neuron, 80, 751-64. CALDERONE, D. J., LAKATOS, P., BUTLER, P. D. & CASTELLANOS, F. X. 2014. Entrainment of neural oscillations as a modifiable substrate of attention. Trends Cogn Sci, 18, 300-9. CAULI, O., RODRIGO, R., LLANSOLA, M., MONTOLIU, C., MONFORT, P., PIEDRAFITA, B., EL MLILI, N., BOIX, J., AGUSTI, A. & FELIPO, V. 2009. Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy. Metab Brain Dis, 24, 69-80. CECERE, R., REES, G. & ROMEI, V. 2015. Individual differences in alpha frequency drive crossmodal illusory perception. Curr Biol, 25, 231-235. CHAKRAVARTHI, R. & VANRULLEN, R. 2012. Conscious updating is a rhythmic process. Proc Natl Acad Sci U S A, 109, 10599-604. CHAUDHRY, V., CORSE, A. M., O'BRIAN, R., CORNBLATH, D. R., KLEIN, A. S. & THULUVATH, P. J. 1999. Autonomic and peripheral (sensorimotor) neuropathy in chronic liver disease: a clinical and electrophysiologic study. Hepatology, 29, 1698-703. COHEN, J. 1988. Statistical power analysis for the behavioral sciences. CONTE, A., FERRAZZANO, G., BELVISI, D., MANZO, N., BATTISTA, E., LI VOTI, P., NARDELLA, A., FABBRINI, G. & BERARDELLI, A. 2018. Somatosensory temporal discrimination in Parkinson's disease, dystonia and essential tremor: 4. Literaturverzeichnis 34 Pathophysiological and clinical implications. Clin Neurophysiol, 129, 1849- 1853. CONTE, A., KHAN, N., DEFAZIO, G., ROTHWELL, J. C. & BERARDELLI, A. 2013. Pathophysiology of somatosensory abnormalities in Parkinson disease. Nat Rev Neurol, 9, 687-97. CONTE, A., LEODORI, G., FERRAZZANO, G., DE BARTOLO, M. I., MANZO, N., FABBRINI, G. & BERARDELLI, A. 2016. Somatosensory temporal discrimination threshold in Parkinson's disease parallels disease severity and duration. Clin Neurophysiol, 127, 2985-2989. CONTE, A., MODUGNO, N., LENA, F., DISPENZA, S., GANDOLFI, B., IEZZI, E., FABBRINI, G. & BERARDELLI, A. 2010. Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinson's disease. Brain, 133, 2656-63. CONTE, A., ROCCHI, L., NARDELLA, A., DISPENZA, S., SCONTRINI, A., KHAN, N. & BERARDELLI, A. 2012. Theta-burst stimulation-induced plasticity over primary somatosensory cortex changes somatosensory temporal discrimination in healthy humans. PLoS One, 7, e32979. CRADDOCK, M., POLIAKOFF, E., EL-DEREDY, W., KLEPOUSNIOTOU, E. & LLOYD, D. M. 2017. Pre-stimulus alpha oscillations over somatosensory cortex predict tactile misperceptions. Neuropsychologia, 96, 9-18. D. HAkUSSINGER, A. T. B., IN: J. RODES, J.-P. BENHAMOU, A.T. BLEI, J. REICHEN, M. RIZZETTO (EDS.) 2007. The Textbook of Hepatology: From Basic Science to Clinical Practise. Oxford: Wiley-Blackwell. DAVIES, M. G., ROWAN, M. J. & FEELY, J. 1990a. Flash visual evoked responses in the early encephalopathy of chronic liver disease. Scand J Gastroenterol, 25, 1205- 14. DAVIES, M. G., ROWAN, M. J. & FEELY, J. 1991. EEG and event related potentials in hepatic encephalopathy. Metab Brain Dis, 6, 175-86. DAVIES, M. G., ROWAN, M. J., MACMATHUNA, P., KEELING, P. W., WEIR, D. G. & FEELY, J. 1990b. The auditory P300 event-related potential: an objective marker of the encephalopathy of chronic liver disease. Hepatology, 12, 688-94. DUGUE, L., MARQUE, P. & VANRULLEN, R. 2011. The phase of ongoing oscillations mediates the causal relation between brain excitation and visual perception. J Neurosci, 31, 11889-93. FIORIO, M., EMADI ANDANI, M., RECCHIA, S. & TINAZZI, M. 2018. The somatosensory temporal discrimination threshold changes after a placebo procedure. Exp Brain Res, 236, 2983-2990. FIORIO, M., RECCHIA, S., CORRA, F., SIMONETTO, S., GARCIA-LARREA, L. & TINAZZI, M. 2012. Enhancing non-noxious perception: behavioural and neurophysiological correlates of a placebo-like manipulation. Neuroscience, 217, 96-104. FRITZ, C. O., MORRIS, P. E. & RICHLER, J. J. 2012. Effect size estimates: current use, calculations, and interpretation. J Exp Psychol Gen, 141, 2-18. GAETZ, W., EDGAR, J. C., WANG, D. J. & ROBERTS, T. P. 2011. Relating MEG measured motor cortical oscillations to resting gamma-aminobutyric acid (GABA) concentration. Neuroimage, 55, 616-21. GONZALEZ-BURGOS, G., HASHIMOTO, T. & LEWIS, D. A. 2010. Alterations of cortical GABA neurons and network oscillations in schizophrenia. Curr Psychiatry Rep, 12, 335-44. 4. Literaturverzeichnis 35 GÖRG, B., QVARTSKHAVA, N., BIDMON, H. J., PALOMERO-GALLAGHER, N., KIRCHEIS, G., ZILLES, K. & HAUSSINGER, D. 2010. Oxidative stress markers in the brain of patients with cirrhosis and hepatic encephalopathy. Hepatology, 52, 256-65. GÖRG, B., SCHLIESS, F. & HAUSSINGER, D. 2013. Osmotic and oxidative/nitrosative stress in ammonia toxicity and hepatic encephalopathy. Arch Biochem Biophys, 536, 158-63. GÖTZ, T., HUONKER, R., KRANCZIOCH, C., REUKEN, P., WITTE, O. W., GUNTHER, A. & DEBENER, S. 2013. Impaired evoked and resting-state brain oscillations in patients with liver cirrhosis as revealed by magnetoencephalography. Neuroimage Clin, 2, 873-82. GROISS, S. J., BUTZ, M., BAUMGARTEN, T. J., FULLENBACH, N. D., HAUSSINGER, D. & SCHNITZLER, A. 2019. GABA-ergic tone hypothesis in hepatic encephalopathy - Revisited. Clin Neurophysiol, 130, 911-916. GUERIT, J. M., AMANTINI, A., FISCHER, C., KAPLAN, P. W., MECARELLI, O., SCHNITZLER, A., UBIALI, E. & AMODIO, P. 2009. Neurophysiological investigations of hepatic encephalopathy: ISHEN practice guidelines. Liver Int, 29, 789-96. HAMMOND, C., BERGMAN, H. & BROWN, P. 2007. Pathological synchronization in Parkinson's disease: networks, models and treatments. Trends Neurosci, 30, 357-64. HAMMOUD, N. & JIMENEZ-SHAHED, J. 2019. Chronic Neurologic Effects of Alcohol. Clin Liver Dis, 23, 141-155. HANNULA, H., NEUVONEN, T., SAVOLAINEN, P., TUKIAINEN, T., SALONEN, O., CARLSON, S. & PERTOVAARA, A. 2008. Navigated transcranial magnetic stimulation of the primary somatosensory cortex impairs perceptual processing of tactile temporal discrimination. Neuroscience Letters, 437, 144- 147. HARRINGTON, D. L., HAALAND, K. Y. & KNIGHT, R. T. 1998. Cortical networks underlying mechanisms of time perception. J Neurosci, 18, 1085-95. HASSAN, S. S., BAUMGARTEN, T. J., ALI, A. M., FULLENBACH, N. D., JORDENS, M. S., HAUSSINGER, D., BUTZ, M., SCHNITZLER, A. & GROISS, S. J. 2019. Cerebellar inhibition in hepatic encephalopathy. Clin Neurophysiol, 130, 886-892. HÄUSSINGER, D. 2004. [Hepatic encephalopathy: clinical aspects and pathogenesis]. Dtsch Med Wochenschr, 129 Suppl 2, S66-7. HÄUSSINGER, D., LAUBENBERGER, J., VOM DAHL, S., ERNST, T., BAYER, S., LANGER, M., GEROK, W. & HENNIG, J. 1994. Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. Gastroenterology, 107, 1475-80. HÄUSSINGER, D. & SIES, H. 2013. Hepatic encephalopathy: clinical aspects and pathogenetic concept. Arch Biochem Biophys, 536, 97-100. HIRSH, I. J. & SHERRICK, C. E., JR. 1961. Perceived order in different sense modalities. J Exp Psychol, 62, 423-32. HOCKERSTEDT, K., KAJASTE, S., MUURONEN, A., RAININKO, R., SEPPALAINEN, A. M. & HILLBOM, M. 1992. Encephalopathy and neuropathy in end-stage liver disease before and after liver transplantation. J Hepatol, 16, 31-7. IEMI, L., CHAUMON, M., CROUZET, S. M. & BUSCH, N. A. 2017. Spontaneous Neural Oscillations Bias Perception by Modulating Baseline Excitability. J Neurosci, 37, 807-819. 4. Literaturverzeichnis 36 JENSEN, O., GIPS, B., BERGMANN, T. O. & BONNEFOND, M. 2014. Temporal coding organized by coupled alpha and gamma oscillations prioritize visual processing. Trends Neurosci, 37, 357-69. JONES, E. A., SCHAFER, D. F., FERENCI, P. & PAPPAS, S. C. 1984. The GABA hypothesis of the pathogenesis of hepatic encephalopathy: current status. Yale J Biol Med, 57, 301-16. JONES, S. R., KERR, C. E., WAN, Q., PRITCHETT, D. L., HAMALAINEN, M. & MOORE, C. I. 2010. Cued Spatial Attention Drives Functionally Relevant Modulation of the Mu Rhythm in Primary Somatosensory Cortex. Journal of Neuroscience, 30, 13760-13765. KAHLBROCK, N., BUTZ, M., MAY, E. S., BRENNER, M., KIRCHEIS, G., HAUSSINGER, D. & SCHNITZLER, A. 2012. Lowered frequency and impaired modulation of gamma band oscillations in a bimodal attention task are associated with reduced critical flicker frequency. Neuroimage, 61, 216-27. KEITEL, V., GORG, B., BIDMON, H. J., ZEMTSOVA, I., SPOMER, L., ZILLES, K. & HAUSSINGER, D. 2010. The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain. Glia, 58, 1794-805. KIRCHEIS, G., FLEIG, W. E., GORTELMEYER, R., GRAFE, S. & HAUSSINGER, D. 2007. Assessment of low-grade hepatic encephalopathy: a critical analysis. J Hepatol, 47, 642-50. KIRCHEIS, G. & HAUSSINGER, D. 2012. [Hepatic encephalopathy]. Dtsch Med Wochenschr, 137, 1582-5. KIRCHEIS, G., HILGER, N. & HAUSSINGER, D. 2014. Value of critical flicker frequency and psychometric hepatic encephalopathy score in diagnosis of low-grade hepatic encephalopathy. Gastroenterology, 146, 961-9. KIRCHEIS, G., WETTSTEIN, M., TIMMERMANN, L., SCHNITZLER, A. & HAUSSINGER, D. 2002. Critical flicker frequency for quantification of low-grade hepatic encephalopathy. Hepatology, 35, 357-66. KLINKE, R., PAPE, H.-C., KURTZ, A., SILBERNAGL, S., BAUMANN, R., BRENNER, B., GAY, R. & ROTHENBURGER, A. 2010. Physiologie. 6., vollständig überarb. Aufl. ed. Stuttgart u.a.: Thieme. KRISTOFFERSON, A. B. 1967. Successiveness Discrimination as a Two-State, Quantal Process. Science, 158, 1337-1339. KULLMANN, F., HOLLERBACH, S., HOLSTEGE, A. & SCHOLMERICH, J. 1995. Subclinical hepatic encephalopathy: the diagnostic value of evoked potentials. J Hepatol, 22, 101-10. KULLMANN, F., HOLLERBACH, S., LOCK, G., HOLSTEGE, A., DIERKS, T. & SCHOLMERICH, J. 2001. Brain electrical activity mapping of EEG for the diagnosis of (sub)clinical hepatic encephalopathy in chronic liver disease. Eur J Gastroenterol Hepatol, 13, 513-22. LACHMANN, V., GORG, B., BIDMON, H. J., KEITEL, V. & HAUSSINGER, D. 2013. Precipitants of hepatic encephalopathy induce rapid astrocyte swelling in an oxidative stress dependent manner. Arch Biochem Biophys, 536, 143-51. LACRUZ, F., ARTIEDA, J., PASTOR, M. A. & OBESO, J. A. 1991. The anatomical basis of somaesthetic temporal discrimination in humans. J Neurol Neurosurg Psychiatry, 54, 1077-81. LANDAU, AYELET N. & FRIES, P. 2012. Attention Samples Stimuli Rhythmically. Current Biology, 22, 1000-1004. 4. Literaturverzeichnis 37 LANDAU, A. N., SCHREYER, H. M., VAN PELT, S. & FRIES, P. 2015. Distributed Attention Is Implemented through Theta-Rhythmic Gamma Modulation. Curr Biol, 25, 2332-7. LANGE, J., HALACZ, J., VAN DIJK, H., KAHLBROCK, N. & SCHNITZLER, A. 2012. Fluctuations of prestimulus oscillatory power predict subjective perception of tactile simultaneity. Cereb Cortex, 22, 2564-74. LANGE, J., KEIL, J., SCHNITZLER, A., VAN DIJK, H. & WEISZ, N. 2014. The role of alpha oscillations for illusory perception. Behav Brain Res, 271, 294-301. LAZAR, M., BUTZ, M., BAUMGARTEN, T. J., FULLENBACH, N. D., JORDENS, M. S., HAUSSINGER, D., SCHNITZLER, A. & LANGE, J. 2018. Impaired Tactile Temporal Discrimination in Patients With Hepatic Encephalopathy. Frontiers in Psychology, 9. LEE, M. S., LEE, M. J., CONTE, A. & BERARDELLI, A. 2018. Abnormal somatosensory temporal discrimination in Parkinson's disease: Pathophysiological correlates and role in motor control deficits. Clin Neurophysiol, 129, 442-447. LIMBACH, K. & CORBALLIS, P. M. 2016. Prestimulus alpha power influences response criterion in a detection task. Psychophysiology, 53, 1154-1164. LORINCZ, M. L., KEKESI, K. A., JUHASZ, G., CRUNELLI, V. & HUGHES, S. W. 2009. Temporal framing of thalamic relay-mode firing by phasic inhibition during the alpha rhythm. Neuron, 63, 683-96. MANDIGA, P., FORIS, L. A., KASSIM, G. & BOLLU, P. C. 2020. Hepatic Encephalopathy. StatPearls. Treasure Island (FL): StatPearls Publishing StatPearls Publishing LLC. MAY, E. S., BUTZ, M., KAHLBROCK, N., BRENNER, M., HOOGENBOOM, N., KIRCHEIS, G., HAUSSINGER, D. & SCHNITZLER, A. 2014. Hepatic encephalopathy is associated with slowed and delayed stimulus-associated somatosensory alpha activity. Clin Neurophysiol, 125, 2427-35. MONTAGNESE, S., AMODIO, P. & MORGAN, M. Y. 2004. Methods for diagnosing hepatic encephalopathy in patients with cirrhosis: a multidimensional approach. Metab Brain Dis, 19, 281-312. MUTHUKUMARASWAMY, S. D., EDDEN, R. A., JONES, D. K., SWETTENHAM, J. B. & SINGH, K. D. 2009. Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humans. Proc Natl Acad Sci U S A, 106, 8356-61. OCHOA-SANCHEZ, R. & ROSE, C. F. 2018. Pathogenesis of Hepatic Encephalopathy in Chronic Liver Disease. J Clin Exp Hepatol, 8, 262-271. OELTZSCHNER, G., BUTZ, M., BAUMGARTEN, T. J., HOOGENBOOM, N., WITTSACK, H. J. & SCHNITZLER, A. 2015. Low visual cortex GABA levels in hepatic encephalopathy: links to blood ammonia, critical flicker frequency, and brain osmolytes. Metab Brain Dis, 30, 1429-38. OLDE DAMINK, S. W., DEUTZ, N. E., DEJONG, C. H., SOETERS, P. B. & JALAN, R. 2002. Interorgan ammonia metabolism in liver failure. Neurochem Int, 41, 177-88. OLESEN, S. S., GRAVERSEN, C., HANSEN, T. M., BLAUENFELDT, R. A., HANSEN, J. B., STEIMLE, K. & DREWES, A. 2011. Spectral and dynamic electroencephalogram abnormalities are correlated to psychometric test performance in hepatic encephalopathy. Scand J Gastroenterol, 46, 988-96. ORTIZ, M., JACAS, C. & CORDOBA, J. 2005. Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations. J Hepatol, 42 Suppl, S45-53. 4. Literaturverzeichnis 38 PASTOR, M. A., DAY, B. L., MACALUSO, E., FRISTON, K. J. & FRACKOWIAK, R. S. 2004. The functional neuroanatomy of temporal discrimination. J Neurosci, 24, 2585- 91. PRAKASH, R. & MULLEN, K. D. 2010. Mechanisms, diagnosis and management of hepatic encephalopathy. Nat Rev Gastroenterol Hepatol, 7, 515-25. RIDDLE, J., HWANG, K., CELLIER, D., DHANANI, S. & D'ESPOSITO, M. 2019. Causal Evidence for the Role of Neuronal Oscillations in Top-Down and Bottom-Up Attention. J Cogn Neurosci, 31, 768-779. ROCCHI, L., CASULA, E., TOCCO, P., BERARDELLI, A. & ROTHWELL, J. 2016. Somatosensory Temporal Discrimination Threshold Involves Inhibitory Mechanisms in the Primary Somatosensory Area. J Neurosci, 36, 325-35. ROMERO-GOMEZ, M., CORDOBA, J., JOVER, R., DEL OLMO, J. A., RAMIREZ, M., REY, R., DE MADARIA, E., MONTOLIU, C., NUNEZ, D., FLAVIA, M., COMPANY, L., RODRIGO, J. M. & FELIPO, V. 2007. Value of the critical flicker frequency in patients with minimal hepatic encephalopathy. Hepatology, 45, 879-85. SCHNITZLER, A. & GROSS, J. 2005. Normal and pathological oscillatory communication in the brain. Nat Rev Neurosci, 6, 285-96. SCHOk LMERICH, J. 2008. Leberzirrhose. Gastroenterologie - Das Referenzwerk für Klinik und Praxis. SENZOLO, M., AMODIO, P., D'ALOISO, M. C., FAGIUOLI, S., DEL PICCOLO, F., CANOVA, D., MASIER, A., BASSANELLO, M., ZANUS, G. & BURRA, P. 2005. Neuropsychological and neurophysiological evaluation in cirrhotic patients with minimal hepatic encephalopathy undergoing liver transplantation. Transplant Proc, 37, 1104-7. SERGEEVA, O. A. 2013. GABAergic transmission in hepatic encephalopathy. Arch Biochem Biophys, 536, 122-30. SHARMA, P., SHARMA, B. C., PURI, V. & SARIN, S. K. 2007. Critical flicker frequency: diagnostic tool for minimal hepatic encephalopathy. J Hepatol, 47, 67-73. SONG, K., MENG, M., CHEN, L., ZHOU, K. & LUO, H. 2014. Behavioral oscillations in attention: rhythmic alpha pulses mediated through theta band. J Neurosci, 34, 4837-44. STROUD, J. M. 1956. The fine structure of psychological time. STURM, W., WILLMES, K., ORGASS, B. & HARTJE, W. 1997. Do Specific Attention Deficits Need Specific Training? Neuropsychological Rehabilitation, 7, 81-103. TIMMERMANN, L., BUTZ, M., GROSS, J., PLONER, M., SUDMEYER, M., KIRCHEIS, G., HAUSSINGER, D. & SCHNITZLER, A. 2008. Impaired cerebral oscillatory processing in hepatic encephalopathy. Clin Neurophysiol, 119, 265-72. TIMMERMANN, L., GROSS, J., BUTZ, M., KIRCHEIS, G., HAUSSINGER, D. & SCHNITZLER, A. 2003. Mini-asterixis in hepatic encephalopathy induced by pathologic thalamo-motor-cortical coupling. Neurology, 61, 689-92. TIMMERMANN, L., GROSS, J., KIRCHEIS, G., HAUSSINGER, D. & SCHNITZLER, A. 2002. Cortical origin of mini-asterixis in hepatic encephalopathy. Neurology, 58, 295- 8. TINAZZI, M., FASANO, A., DI MATTEO, A., CONTE, A., BOVE, F., BOVI, T., PERETTI, A., DEFAZIO, G., FIORIO, M. & BERARDELLI, A. 2013. Temporal discrimination in patients with dystonia and tremor and patients with essential tremor. Neurology, 80, 76-84. 4. Literaturverzeichnis 39 TORLOT, F. J., MCPHAIL, M. J. & TAYLOR-ROBINSON, S. D. 2013. Meta-analysis: The diagnostic accuracy of critical flicker frequency in minimal hepatic encephalopathy. Aliment Pharmacol Ther, 37, 527-36. UHLHAAS, P. J. & SINGER, W. 2006. Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology. Neuron, 52, 155-68. VANRULLEN, R. 2006. The Continuous Wagon Wheel Illusion Is Associated with Changes in Electroencephalogram Power at 13 Hz. Journal of Neuroscience, 26, 502-507. VANRULLEN, R. 2016. Perceptual Cycles. Trends Cogn Sci, 20, 723-735. VARELA, F. J., TORO, A., JOHN, E. R. & SCHWARTZ, E. L. 1981. Perceptual framing and cortical alpha rhythm. Neuropsychologia, 19, 675-86. VILSTRUP, H., AMODIO, P., BAJAJ, J., CORDOBA, J., FERENCI, P., MULLEN, K. D., WEISSENBORN, K. & WONG, P. 2014. Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology, 60, 715-35. WAGER, T. D., RILLING, J. K., SMITH, E. E., SOKOLIK, A., CASEY, K. L., DAVIDSON, R. J., KOSSLYN, S. M., ROSE, R. M. & COHEN, J. D. 2004. Placebo-induced changes in FMRI in the anticipation and experience of pain. Science, 303, 1162-7. WEINBERGER, M. & DOSTROVSKY, J. O. 2011. A basis for the pathological oscillations in basal ganglia: the crucial role of dopamine. Neuroreport, 22, 151-6. WEISSENBORN, K. 2019. Hepatic Encephalopathy: Definition, Clinical Grading and Diagnostic Principles. Drugs, 79, 5-9. WEISSENBORN, K., GIEWEKEMEYER, K., HEIDENREICH, S., BOKEMEYER, M., BERDING, G. & AHL, B. 2005. Attention, memory, and cognitive function in hepatic encephalopathy. Metab Brain Dis, 20, 359-67. WUTZ, A., WEISZ, N., BRAUN, C. & MELCHER, D. 2014. Temporal windows in visual processing: "prestimulus brain state" and "poststimulus phase reset" segregate visual transients on different temporal scales. J Neurosci, 34, 1554- 65. YANG, S. S., CHU, N. S. & LIAW, Y. F. 1985. Somatosensory evoked potentials in hepat | |||||||
| Lizenz: |  Urheberrechtsschutz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 13.10.2020 | |||||||
| Dateien geändert am: | 13.10.2020 | |||||||
| Promotionsantrag am: | 07.10.2020 | |||||||
| Datum der Promotion: | 07.10.2020 |
