Dokument: Impact of material properties, process parameters and roll compactor design on roll compaction

Titel:	Impact of material properties, process parameters and roll compactor design on roll compaction
URL für Lesezeichen:	https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=51572
URN (NBN):	urn:nbn:de:hbz:061-20191125-115554-0
Kollektion:	Dissertationen
Sprache:	Englisch
Dokumententyp:	Wissenschaftliche Abschlussarbeiten » Dissertation
Medientyp:	Text
Autor:	Szappanos-Csordas, Kitti [Autor]
Dateien:	[Dateien anzeigen] Adobe PDF [Details] 8,58 MB in einer Datei [ZIP-Datei erzeugen] Dateien vom 17.11.2019 / geändert 17.11.2019
Beitragende:	Prof. Dr. Kleinebudde, Peter [Gutachter] Prof. Dr. Breitkreutz, Jörg [Gutachter]
Dewey Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit
Beschreibung:	Impact of material properties, process parameters and roll compactor design on roll compaction Numerous types of roll compactors are on the market, which distinguish themselves in their configuration, design of roll compaction, performance and the extents to set the process parameters. Because of these discrepancies and the lack of knowledge in this field, the systematical investigation of different types or roll compactors was the main goal of the present thesis. Ribbons were manufactured using inclined, horizontal and vertical roll compaction designs, respectively. The impact of the process parameters, roll compaction design and the type of material on the ribbon and granule characteristics were systematically investigated within the scope of design of experiments. The performance of roll compactors was evaluated in regards to the precision and the deviation from the set value of HP/SCF and GW depending on the roll compaction design and used model materials. The best results for deviation from a set value, precision and settling time of the process data was found in case of the tested Mini-Pactor, while the tested BRC 25 roll compactor provided slightly higher deviations and less precise control in the actual test setting. The impact of material properties, process parameters and roll compaction design on roll compaction was investigated through the evaluation of the ribbon RD. The most significant process parameter was the HP/SCF independently from the implemented roll compaction design, type of roll compactor or model material. The compaction of mannitol powder led to the densest ribbons due to its sphere morphology and collapse under compaction resulting in high RD. The fraction of MCC had an adverse effect on the ribbon RD, as the MCC ribbons underwent elastic recovery after ejection from the nip zone. Two different techniques of the ribbon RD measurement were compared to each other; the GeoPyc powder pycnometry, as conventional method and the x-ray µCT, as a more established and complex method. However the x-ray µCT tool might provide more accurate RD results than the powder pycnometry, it is easier, faster and more cost-effective to measure the RD of ribbons by GeoPyc. Theoretical principles of the process transfer were shown, in which the ribbon RD-based transfer of roll compaction was successfully accomplished applying the calculated cf-s. One of the main drawbacks of roll compaction/dry granulation is the production of high amount of fines resulting in bimodal GSD. It was shown that the amount of fines is a function of the set HP/SCF, GW, the type of material and the used type of roll surface for the AlexanderWerk BT120 roll compactor and for the BRC 25 roll compactor. It was proved that the ribbon RD and the type of material govern the GSD through the effect of roll compaction design and process parameters. The design of roll compaction had an influence on the ribbon and granule properties, but the influence of the process parameters and type of materials were found to be more important and can overrule the design effects.
Lizenz:	Urheberrechtsschutz
Fachbereich / Einrichtung:	Mathematisch- Naturwissenschaftliche Fakultät
Dokument erstellt am:	25.11.2019
Dateien geändert am:	25.11.2019
Promotionsantrag am:	18.12.2018
Datum der Promotion:	30.01.2019