Dokument: The role of radiosurgery for the management of benign intracranial meningiomas
| Titel: | The role of radiosurgery for the management of benign intracranial meningiomas | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=44556 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20180104-151301-5 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | Dr Santacroce, Antonio [Autor] | |||||||
| Dateien: |
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| Beitragende: | Prof. Dr. Steiger, Hans-Jakob [Gutachter] Prof. Dr. Dr. Schipper, Jörg [Gutachter] | |||||||
| Stichwörter: | Control rate, Follow-up, Meningiomas, Multicenter study, Radiosurgery | |||||||
| Dewey Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit | |||||||
| Beschreibung: | BACKGROUND: Radiosurgery is the main alternative to microsurgical resection for benign
meningiomas. OBJECTIVE: To assess the long-term efficacy and safety of radiosurgery for meningiomas with respect to tumor growth and prevention of associated neurological deterioration. Medium- to long-term outcomes have been widely reported, but no large multicenter series with long-term follow-up have been published. METHODS: From 15 participating centers, we performed a retrospective observational analysis of 4565 consecutive patients harboring 5300 benign meningiomas. All were treated with Gamma Knife radiosurgery at least 5 years before assessment for this study. Clinical and imaging data were retrieved from each center and uniformly entered into a database by 1 author (A.S.). RESULTS: Median tumor volume was 4.8 cm3, and median dose to tumor margin was 14 Gy. All tumors with imaging follow-up < 24 months were excluded. Detailed results from 3768 meningiomas (71%) were analyzed. Median imaging follow-up was 63 months. The volume of treated tumors decreased in 2187 lesions (58%), remained unchanged in 1300 lesions (34.5%), and increased in 281 lesions (7.5%), giving a control rate of 92.5%. Only 84 (2.2%) enlarging tumors required further treatment. Five- and 10-year progression free survival rates were 95.2% and 88.6%, respectively. Tumor control was higher for imaging defined tumors vs grade I meningiomas (P< .001), for female vs male patients (P < .001), for sporadic vs multiple meningiomas (P< .001), and for skull base vs convexity tumors (P < .001). Permanent morbidity rate was 6.6% at the last follow-up. CONCLUSION: Radiosurgery is a safe and effective method for treating benign meningiomas even in the medium to long term. | |||||||
| Lizenz: |  Urheberrechtsschutz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 04.01.2018 | |||||||
| Dateien geändert am: | 04.01.2018 | |||||||
| Promotionsantrag am: | 12.10.2016 | |||||||
| Datum der Promotion: | 07.06.2017 |
