Dokument: Development and Critical Evaluation of Membrane Electrodes as Electronic Tongue Sensors for Pharmaceutical Applications
| Titel: | Development and Critical Evaluation of Membrane Electrodes as Electronic Tongue Sensors for Pharmaceutical Applications | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=43997 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20171027-104726-5 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | Immohr, Laura Isabell [Autor] | |||||||
| Dateien: |
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| Beitragende: | Prof. Dr. Pein-Hackelbusch, Miriam [Gutachter] Prof. Dr. Breitkreutz, Jörg [Gutachter] | |||||||
| Stichwörter: | electronic tongues, membrane electrodes, sensors, taste assessment, taste-masking, pediatrics, oral pharmaceuticals | |||||||
| Dewey Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik » 570 Biowissenschaften; Biologie | |||||||
| Beschreibung: | This thesis addresses the urgent need for the definition of quality attributes for electronic tongue systems used for the taste assessment in the development of palatable oral pharmaceuticals on the basis of the sensor array. The preparation of polymer-based membrane electrodes provides insights in composition, manufacturing processes, performance and applications of the sensors. This knowledge was used for the definition of quality attributes for electronic tongue sensors regardless from the method of manufacturing or basic measurement principle including the stability of the sensor responses, the reproducibility, robustness and the sensitivity. These criteria opens the discussion for the legislation of electronic tongues by regulatory authorities.
The acquired knowledge on the composition of membrane electrodes for the characterization of multicomponent solutions was furthermore used for individual manufacturing of specialized electronic tongue sensors for specific pharmaceutical questions. As differences in taste and pharmacological activity of enantiomers is challenge in the characterization of oral pharmaceuticals, the incorporation of cyclodextrins in the polymer membranes that enabled the stereoselective analysis of pharmaceuticals was one of the major achievements of this thesis. Beside this, correlation of in-vitro and in-vivo taste data increased the clinical relevance of electronic tongues during this work and enabled their application for the development of taste-masked pharmaceuticals as well as it justified the implementation of electronic tongues for additional analytical tasks in the field of pharmaceutics. This approach facilitates the application of electronic tongue sensors for the taste-masking assessment of different multicomponent beverages and for the detection of drug release profiles in biorelevant artificial saliva demonstrating that the drawbacks of turbid and multicomponent sample media for the analytic by UV spectroscopy were overcome. With regard to the achievements in the comprehension of electronic tongue sensors and their application, this thesis offers the opportunity of standardizing the characterization of oral pharmaceuticals by electronic tongue systems with defined quality criteria for a future approach to approve electronic tongues by regulatory authorities. Furthermore, the superiority of the sensor arrays for special pharmaceutical and analytical applications was demonstrated and the relevance of electronic tongues as analytical tools in the field of pharmaceutical sciences was strengthen. | |||||||
| Lizenz: |  Urheberrechtsschutz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät » WE Pharmazie » Pharmazeutische Technologie und Biopharmazie | |||||||
| Dokument erstellt am: | 27.10.2017 | |||||||
| Dateien geändert am: | 27.10.2017 | |||||||
| Promotionsantrag am: | 03.04.2017 | |||||||
| Datum der Promotion: | 02.06.2017 |
