Dokument: Evaluation of iron status in voluntary blood donors

Titel:

Evaluation of iron status in voluntary blood donors

Weiterer Titel:

Evaluation of iron status in voluntary blood donors

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https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=42233

URN (NBN):

urn:nbn:de:hbz:061-20170502-094721-1

Kollektion:

Dissertationen

Sprache:

Englisch

Dokumententyp:

Wissenschaftliche Abschlussarbeiten » Dissertation

Medientyp:

Text

Autor:

Toolabi, Abdolmajid [Autor]

Dateien:

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Dateien vom 02.05.2017 / geändert 02.05.2017

Beitragende:

Prof. Dr. Dr. Giers, Günther [Gutachter]
Prof. Dr. Gattermann, Norbert [Gutachter]

Stichwörter:

Blood donation; Iron deficiency; Iron stores; Ferritin; Hemoglobin; Dusseldorf

Dewey Dezimal-Klassifikation:

600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit

Beschreibungen:

Introduction:

Blood is a vital fluid for human life. Essential needs of all cells and organs of the body are provided by blood. Human with all the scientific and technological progresses have been so far failed to find a proper alternative for blood. In fact, blood donation is called "life donation".
However, blood donors are more susceptible to iron deficiency, since in each blood donation they will lose between 200 to 250 mg of their iron stores.

Aim of study:
Iron deficiency is one of the well-known risk factors of blood donation attempts deferral worldwide. Hence, aim of this study is to evaluate iron status of blood donors with more laboratory examinations. This is investigated to see if iron deficiency can be one of the possible reasons for the decrease in statistics of blood donation in the University Hospital Dusseldorf.

Materials and methods:
During this study, randomly 280 volunteer's data inclusive 30 first-time donors and 250 frequent donors (more than one donation) with equal male to female ratio and average age of 34.9 years have been analyzed after receiving statement of University Ethic Commission.
For all donors, complete blood count (CBC) test and special iron tests including serum iron, serum ferritin, transferrin and transferrin receptors have been done and relevant information was extracted. Evaluation of the data was conducted using with the statistical software SPSS (version 20) and R (version 3.0.1).

Results:
The relationship between serum ferritin level and the number of donations was statistically significant (P 0.000). Overall 21.77% (61 of 280) of all donors had iron store deficiency (serum ferritin < 15µg/l) including 60 frequent donors and only one first time donor. 26% of all donors with more than 5 donations had a latent iron deficiency. A significant relationship was observed between ferritin level and donor’s gender (P<0.05). Iron store depletion among the female donors occurs about two times more common than among the males (28.57% (40) vs. 15% (21).

Conclusion:
According to the results obtained, as the blood donation count increases, serum ferritin level decreases. It is based on international experiences and confirms previous studies on the impact of blood donation on depletion of the body iron storage. Iron store deficiency can also be one of the reasons for the decrease in the number of blood donation in the University Hospital Dusseldorf. That is why donors who are at this stage and do not receive iron supplements, can get close to the iron deficiency anemia in the near future. Indeed, their hemoglobin level can be lower than the standard value for blood donation. Hence, they would not be able to donate blood anymore. The results also indicate the need to regulatory monitoring the iron status of voluntary blood donors.

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Lizenz:

Urheberrechtsschutz

Fachbereich / Einrichtung:

Medizinische Fakultät

Dokument erstellt am:

02.05.2017

Dateien geändert am:

02.05.2017

Promotionsantrag am:

10.04.2014

Datum der Promotion:

11.04.2017

Heinrich-Heine-Universität Düsseldorf

Dokument: Evaluation of iron status in voluntary blood donors