Dokument: Myelodysplastic Syndromes: evaluation of different prognostic scores in patients treated with chemotherapy
| Titel: | Myelodysplastic Syndromes: evaluation of different prognostic scores in patients treated with chemotherapy | |||||||
| Weiterer Titel: | Myelodysplastische Symdrome: Evaluation des prognostischen Wertes von WPSS und Vergleich mit den Indices IPSS und IPSS-R bezogen auf Patienten mit Chemotherapie | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=40371 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20161110-111700-2 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | Dott. (It) Martino, Samuela [Autor] | |||||||
| Dateien: |
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| Beitragende: | Prof. Dr. Germing, Ulrich [Gutachter] Prof. Dr. med Boeken, Udo [Gutachter] | |||||||
| Stichwörter: | MDS; WPSS; IPSS; IPSS-R; Prognosis | |||||||
| Dewey Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit | |||||||
| Beschreibung: | Myelodysplastic syndromes (MDS) are a heterogeneous group of pathologies that may have extremely different clinical developments. A proper classification score is useful not only for defining prognosis, but also to identify the best therapeutic approach. This was a multicenter study involving 375 patients from Germany and Italy. Our study started with the intent to investigate the validity of the WHO classification-based Prognostic Scoring System (WPSS) on the outcome of patients who underwent chemotherapy and/or treated with 5-Azacitidine. We extended then the analysis to compare this score with the well-known International Prognostic Scoring System (IPSS) and the most recently proposed Revised International Prognostic Scoring System (IPSS-R). The general overall survival (OS) was of 26 months. Based on the univariate analysis age, transfusion dependency, AML-evolution and chromosomal aberrations were significant predictors of patients’ outcome. Using proportional hazard regression multivariate analysis, the most significant independent variables for predicting the outcome of our patients were age, Hb according to IPSS classification, blast percentage and chromosomal aberrations stratified according to the new IPSS-R criteria. The WHO-classification showed a significant role to define the risk of AML-Transformation, together with chromosomal aberrations and the need of transfusions in follow up. Moreover, the evaluation of survival curves, according to the Kaplan-Meier method, shows that, even if the three scores have all a prognostic significance on OS, the new IPSS-R score provides a better stratification of patients as far as prognosis and risk of AML-evolution is concerned. | |||||||
| Lizenz: |  Urheberrechtsschutz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 10.11.2016 | |||||||
| Dateien geändert am: | 10.11.2016 | |||||||
| Promotionsantrag am: | 14.12.2015 | |||||||
| Datum der Promotion: | 26.10.2016 |
