Dokument: Ross-Operation versus mechanischer Klappenersatz als Strategie zur operativen Behandlung der erkrankten Aortenklappe

Titel:	Ross-Operation versus mechanischer Klappenersatz als Strategie zur operativen Behandlung der erkrankten Aortenklappe
URL für Lesezeichen:	https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=38559
URN (NBN):	urn:nbn:de:hbz:061-20160610-085621-4
Kollektion:	Dissertationen
Sprache:	Deutsch
Dokumententyp:	Wissenschaftliche Abschlussarbeiten » Dissertation
Medientyp:	Text
Autor:	Dr. Smiris, Konstantinos [Autor]
Dateien:	[Dateien anzeigen] Adobe PDF [Details] 1019,4 KB in einer Datei [ZIP-Datei erzeugen] Dateien vom 10.06.2016 / geändert 10.06.2016
Beitragende:	Prof. Dr. Lichtenberg, Artur [Gutachter] PD Dr. Kindgen-Milles, Detlef [Gutachter]
Stichwörter:	Ross-Operation, mechanischer Aortenklappenersatz, full root, reinforcement
Dewey Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit
Beschreibung:	Den primären Therapieansatz bei der operativen Versorgung von Aortenklappenvitien stellt die Aortenklappenrekonstruktion dar. Sofern diese nicht möglich ist, gilt der Aortenklappenersatz als Standardverfahren. Hierbei treten jedoch klappenspezifische Komplikationen auf. Diese sind besonders bei mechanischen Aortenklappenprothesen, welche bei jüngeren Patienten indiziert sind, gravierend. Die Ross-Operation bietet für diese Patienten eine geeignete Alternative. Allerdings gibt es mehrere Abwandlungen der Operationstechnik, die dementsprechend auch das Langzeitergebnis beeinflussen. In unserer Klinik wurde die Ross-Operation ab 2009 als „full root mit reinforcement“, also als kompletter Wurzelersatz mit Verstärkung, durchgeführt. Es wurden insgesamt 100 Patienten nachuntersucht, die im Zeitraum 08/2008 bis 02/2014 eine isolierte Ross-Operation (Ross-Gruppe) oder einen mechanischen Klappenersatz erhalten haben (mAKE-Gruppe). Unter Berücksichtigung der Strukturgleichheit ergab sich aus einer „matched pair“-Analyse eine endgültige Stichprobe von 80 Patienten. Diese unterteilt sich in jeweils 40 Patienten für jede Gruppe. Die Nachuntersuchung erfolgte Ende 2014, wobei der Schwerpunkt, auf der echokardiografischen 2-Jahres-Nachkontrolle, dem postoperativen Verlauf sowie dem aktuellen Gesundheitszustand liegt. Die zu erhebenden Parameter umfassen echokardiografische Ergebnisse, unter Berücksichtigung der Druckgradienten an der Aortenklappe, das peri- und postoperative Ergebnis, insbesondere hinsichtlich postoperativer Komplikationen, sowie die jetzige Lebensqualität der Patienten nach dem EQ-5D-3L Fragebogen. Trotz längerer Operationszeit und intraoperativer Ischämiezeit des Herzens, zeigte die Ross-Gruppe, eine geringere postoperative Beatmungszeit und Gesamtaufenthaltsdauer. Hinsichtlich der perioperativen und frühpostoperativen Komplikationen, der Lebensqualität und des Einflusses der unterschiedlichen Hämodynamik auf die Herzfunktion, fanden sich keine statistisch signifikanten Unterschiede zwischen den beiden Gruppen. Die gemessenen Druckgradienten waren in der Ross-Gruppe signifikant niedriger und mit den Ergebnissen anderer Arbeitsgruppen vergleichbar. Die Gesundheitsempfindung der Patienten nach Ross-Operation war signifikant höher. Die Risikofaktorenanalyse ergab ein Risiko für Verziehungen des Autografts bei vorangegangener Operation an der Aortenklappe sowie bei akuter Aortenklappenendokarditis. Die Inzidenz schwerer thromboembolischer Komplikationen sowie die Mortalität waren zum Zeitpunkt der Nachuntersuchung in der Patientengruppe nach mechanischen Klappenersatz signifikant höher. Die vorliegende Studie konnte nachweisen, dass die Ross-Operation als eine vom Gesamtrisiko her vergleichbare Alternative zum mechanischen Klappenersatz zu werten ist, die bei symptomatischen Patienten, die nicht voroperiert sind und keine Endokarditis haben, in Erwägung gezogen werden sollte.
Quelle:	AICHER, D., HOLZ, A., FELDNER, S., KOLLNER, V. & SCHAFERS, H. J. 2011. Quality of life after aortic valve surgery: replacement versus reconstruction. J Thorac Cardiovasc Surg, 142, e19-24. ALAVI, S. H. & KHERADVAR, A. 2015. A Hybrid Tissue-Engineered Heart Valve. Ann Thorac Surg, 99, 2183-7. ALJASSIM, O., SVENSSON, G., PERROTTA, S., JEPPSSON, A. & BECH-HANSSEN, O. 2011. Dilatation of the pulmonary autograft and native aorta after the Ross procedure: a comprehensive echocardiographic study. J Thorac Cardiovasc Surg, 142, 634-40, 640.e1. ANDREAS, M., WIEDEMANN, D., SEEBACHER, G., RATH, C., AREF, T., ROSENHEK, R., HEINZE, G., EIGENBAUER, E., SIMON, P., RUETZLER, K., HIESMAYR, J. M., MORITZ, A., LAUFER, G. & KOCHER, A. 2014. The Ross procedure offers excellent survival compared with mechanical aortic valve replacement in a real-world setting. Eur J Cardiothorac Surg, 46, 409-13; discussion 413-4. ANGELONI, E., MELINA, G., PIBAROT, P., BENEDETTO, U., REFICE, S., CIAVARELLA, G. M., ROSCITANO, A., SINATRA, R. & PEPPER, J. R. 2012. Impact of prosthesis-patient mismatch on the regression of secondary mitral regurgitation after isolated aortic valve replacement with a bioprosthetic valve in patients with severe aortic stenosis. Circ Cardiovasc Imaging, 5, 36-42. BACH, D. S., SAKWA, M. P., GOLDBACH, M., PETRACEK, M. R., EMERY, R. W. & MOHR, F. W. 2002. Hemodynamics and early clinical performance of the St. Jude Medical Regent mechanical aortic valve. Ann Thorac Surg, 74, 2003-9; discussion 2009. BECKMANN, A., HAMM, C., FIGULLA, H. R., CREMER, J., KUCK, K. H., LANGE, R., ZAHN, R., SACK, S., SCHULER, G. C., WALTHER, T., BEYERSDORF, F., BOHM, M., HEUSCH, G., FUNKAT, A. K., MEINERTZ, T., NEUMANN, T., PAPOUTSIS, K., SCHNEIDER, S., WELZ, A. & MOHR, F. W. 2012. The German Aortic Valve Registry (GARY): a nationwide registry for patients undergoing invasive therapy for severe aortic valve stenosis. Thorac Cardiovasc Surg, 60, 319-25. BENTALL, H. & DE BONO, A. 1968. A technique for complete replacement of the ascending aorta. Thorax, 23, 338-9. BLOME-EBERWEIN, S. A., MROWINSKI, D., HOFMEISTER, J. & HETZER, R. 1996. Impact of mechanical heart valve prosthesis sound on patients' quality of life. Ann Thorac Surg, 61, 594-602. BOTHA, C. A. 2005. The Ross operation: utilization of the patient's own pulmonary valve as a replacement device for the diseased aortic valve. Expert Rev Cardiovasc Ther, 3, 1017-26. BROWN, J. M., O'BRIEN, S. M., WU, C., SIKORA, J. A., GRIFFITH, B. P. & GAMMIE, J. S. 2009. Isolated aortic valve replacement in North America comprising 108,687 patients in 10 years: changes in risks, valve types, and outcomes in the Society of Thoracic Surgeons National Database. J Thorac Cardiovasc Surg, 137, 82-90. BROWN, J. W., ELKINS, R. C., CLARKE, D. R., TWEDDELL, J. S., HUDDLESTON, C. B., DOTY, J. R., FEHRENBACHER, J. W. & TAKKENBERG, J. J. 2010a. Performance of the CryoValve SG human decellularized pulmonary valve in 342 patients relative to the conventional CryoValve at a mean follow-up of four years. J Thorac Cardiovasc Surg, 139, 339-48. BROWN, J. W., RUZMETOV, M., SHAHRIARI, A., RODEFELD, M. D., TURRENTINE, M. W. & MAHOMED, Y. 2011. The Ross full root replacement in adults with bicuspid aortic valve disease. J Heart Valve Dis, 20, 332-9; discussion 340. BROWN, J. W., RUZMETOV, M., SHAHRIARI, A. P., RODEFELD, M. D., MAHOMED, Y. & TURRENTINE, M. W. 2010b. Modification of the Ross aortic valve replacement to prevent late autograft dilatation. Eur J Cardiothorac Surg, 37, 1002-7. CABROL, C., CABROL, A., GUIRAUDON, G. & BERTRAND, M. 1966. [Treatment of aortic insufficiency by means of aortic annuloplasty]. Arch Mal Coeur Vaiss, 59, 1305-12. CARR-WHITE, G. S., AFOKE, A., BIRKS, E. J., HUGHES, S., O'HALLORAN, A., GLENNEN, S., EDWARDS, S., EASTWOOD, M. & YACOUB, M. H. 2000. Aortic root characteristics of human pulmonary autografts. Circulation, 102, Iii15-21. CARR-WHITE, G. S., KILNER, P. J., HON, J. K., RUTLEDGE, T., EDWARDS, S., BURMAN, E. D., PENNELL, D. J. & YACOUB, M. H. 2001. Incidence, location, pathology, and significance of pulmonary homograft stenosis after the Ross operation. Circulation, 104, I16-20. CARREL, T., SCHWERZMANN, M., ECKSTEIN, F., AYMARD, T. & KADNER, A. 2008. Preliminary results following reinforcement of the pulmonary autograft to prevent dilatation after the Ross procedure. J Thorac Cardiovasc Surg, 136, 472-5. CHARITOS, E. I., HANKE, T., STIERLE, U., ROBINSON, D. R., BOGERS, A. J., HEMMER, W., BECHTEL, M., MISFELD, M., GORSKI, A., BOEHM, J. O., REIN, J. G., BOTHA, C. A., LANGE, R., HOERER, J., MORITZ, A., WAHLERS, T., FRANKE, U. F., BREUER, M., FERRARI-KUEHNE, K., HETZER, R., HUEBLER, M., ZIEMER, G., TAKKENBERG, J. J. & SIEVERS, H. H. 2009. Autograft reinforcement to preserve autograft function after the ross procedure: a report from the german-dutch ross registry. Circulation, 120, S146-54. CHARITOS, E. I., TAKKENBERG, J. J., HANKE, T., GORSKI, A., BOTHA, C., FRANKE, U., DODGE-KHATAMI, A., HOERER, J., LANGE, R., MORITZ, A., FERRARI-KUEHNE, K., HETZER, R., HUEBLER, M., BOGERS, A. J., STIERLE, U., SIEVERS, H. H. & HEMMER, W. 2012. Reoperations on the pulmonary autograft and pulmonary homograft after the Ross procedure: An update on the German Dutch Ross Registry. J Thorac Cardiovasc Surg, 144, 813-21; discussion 821-3. CHEN, C., RODRIGUEZ, L., GUERRERO, J. L., MARSHALL, S., LEVINE, R. A., WEYMAN, A. E. & THOMAS, J. D. 1991. Noninvasive estimation of the instantaneous first derivative of left ventricular pressure using continuous-wave Doppler echocardiography. Circulation, 83, 2101-10. CHEUNG, D. Y., DUAN, B. & BUTCHER, J. T. 2015. Current progress in tissue engineering of heart valves: multiscale problems, multiscale solutions. Expert Opin Biol Ther, 15, 1155-72. CHIKWE, J., KAMATH, A. & STELZER, P. 2011. Ross procedure. Multimed Man Cardiothorac Surg, 2011, mmcts.2009.004176. CONKLIN, L. D. & REARDON, M. J. 2001. Technical aspects of the Ross procedure. Tex Heart Inst J, 28, 186-9. DA COSTA, F. D., SANTOS, L. R., COLLATUSSO, C., MATSUDA, C. N., LOPES, S. A., CAUDURO, S., RODERJAN, J. G. & INGHAM, E. 2009. Thirteen years' experience with the Ross Operation. J Heart Valve Dis, 18, 84-94. DAVID, T. E. 2013. Surgical treatment of aortic valve disease. Nat Rev Cardiol, 10, 375-86. DAVID, T. E., FEINDEL, C. M., DAVID, C. M. & MANLHIOT, C. 2014. A quarter of a century of experience with aortic valve-sparing operations. J Thorac Cardiovasc Surg, 148, 872-9; discussion 879-80. DAVID, T. E., OMRAN, A., WEBB, G., RAKOWSKI, H., ARMSTRONG, S. & SUN, Z. 1996. Geometric mismatch of the aortic and pulmonary roots causes aortic insufficiency after the Ross procedure. J Thorac Cardiovasc Surg, 112, 1231-7; discussion 1237-9. DAVID, T. E., WOO, A., ARMSTRONG, S. & MAGANTI, M. 2010. When is the Ross operation a good option to treat aortic valve disease? J Thorac Cardiovasc Surg, 139, 68-73; discussion 73-5. DIMITRAKAKIS, G., PODILA, S. R., O'KEEFE, P. A. & KULATILAKE, N. E. 2011. Biological glue: a word of careful assessment! Interact Cardiovasc Thorac Surg, 13, 244-5. ELKINS, R. C. 1999. The Ross operation: a 12-year experience. Ann Thorac Surg, 68, S14-8. ELKINS, R. C., DAWSON, P. E., GOLDSTEIN, S., WALSH, S. P. & BLACK, K. S. 2001. Decellularized human valve allografts. Ann Thorac Surg, 71, S428-32. ELKINS, R. C., THOMPSON, D. M., LANE, M. M., ELKINS, C. C. & PEYTON, M. D. 2008. Ross operation: 16-year experience. J Thorac Cardiovasc Surg, 136, 623-30, 630.e1-5. FAGGIANO, P., ANTONINI-CANTERIN, F., RIBICHINI, F., D'ALOIA, A., FERRERO, V., CERVESATO, E., PAVAN, D., BURELLI, C. & NICOLOSI, G. 2000. Pulmonary artery hypertension in adult patients with symptomatic valvular aortic stenosis. Am J Cardiol, 85, 204-8. FEIER, H., COLLART, F., GHEZ, O., RIBERI, A., CAUS, T., KREITMANN, B. & METRAS, D. 2005. Risk factors, dynamics, and cutoff values for homograft stenosis after the Ross procedure. Ann Thorac Surg, 79, 1669-75; discussion 1675. FRATER, R. W. 1986. Aortic valve insufficiency due to aortic dilatation: correction by sinus rim adjustment. Circulation, 74, I136-42. GOLCZYK, K., KOMPIS, M., ENGLBERGER, L., CARREL, T. P. & STALDER, M. 2010. Heart valve sound of various mechanical composite grafts, and the impact on patients' quality of life. J Heart Valve Dis, 19, 228-32. HAMMERMEISTER, K., SETHI, G. K., HENDERSON, W. G., GROVER, F. L., OPRIAN, C. & RAHIMTOOLA, S. H. 2000. Outcomes 15 years after valve replacement with a mechanical versus a bioprosthetic valve: final report of the Veterans Affairs randomized trial. J Am Coll Cardiol, 36, 1152-8. HINZ, A., KOHLMANN, T., STOBEL-RICHTER, Y., ZENGER, M. & BRAHLER, E. 2014. The quality of life questionnaire EQ-5D-5L: psychometric properties and normative values for the general German population. Qual Life Res, 23, 443-7. IUNG, B. & RODES-CABAU, J. 2014. The optimal management of anti-thrombotic therapy after valve replacement: certainties and uncertainties. Eur Heart J, 35, 2942-9. JASHARI, R., GOFFIN, Y., VANDERKELEN, A., VAN HOECK, B., DU VERGER, A., FAN, Y., HOLOVSKA, V. & BRAHY, O. 2010. European homograft bank: twenty years of cardiovascular tissue banking and collaboration with transplant coordination in Europe. Transplant Proc, 42, 183-9. JAZAYERI, S., GOMEZ, M. C., TATOU, E., ECARNOT, A., SALEH, M., BOUCHOT, O., RENAUD, C., BRENOT, R. & DAVID, M. 2003. Clinical experience and Doppler echocardiographic assessment of the first one hundred ATS AP (advanced performance) prosthetic valve in the aortic position. J Heart Valve Dis, 12, 628-34; discussion 634. JUTHIER, F., BANFI, C., VINCENTELLI, A., ENNEZAT, P. V., LE TOURNEAU, T., PINCON, C. & PRAT, A. 2010. Modified Ross operation with reinforcement of the pulmonary autograft: Six-year results. J Thorac Cardiovasc Surg, 139, 1420-3. KALFA, D., FEIER, H., LOUNDOU, A., FRAISSE, A., MACE, L., METRAS, D. & KREITMANN, B. 2011. Cryopreserved homograft in the Ross procedure: outcomes and prognostic factors. J Heart Valve Dis, 20, 571-81. KLIEVERIK, L. M., TAKKENBERG, J. J., BEKKERS, J. A., ROOS-HESSELINK, J. W., WITSENBURG, M. & BOGERS, A. J. 2007. The Ross operation: a Trojan horse? Eur Heart J, 28, 1993-2000. KOUCHOUKOS, N. T., MASETTI, P., NICKERSON, N. J., CASTNER, C. F., SHANNON, W. D. & DAVILA-ROMAN, V. G. 2004. The Ross procedure: long-term clinical and echocardiographic follow-up. Ann Thorac Surg, 78, 773-81; discussion 773-81. LEMAIRE, S. A., SCHMITTLING, Z. C., COSELLI, J. S., UNDAR, A., DEADY, B. A., CLUBB, F. J., JR. & FRASER, C. D., JR. 2002. BioGlue surgical adhesive impairs aortic growth and causes anastomotic strictures. Ann Thorac Surg, 73, 1500-5; discussion 1506. LIEBRICH, M., WEIMAR, T., TZANAVAROS, I., ROSER, D., DOLL, K. N. & HEMMER, W. B. 2014. The David Procedure for Salvage of a Failing Autograft After the Ross Operation. Ann Thorac Surg. LUCIANI, G. B. & MAZZUCCO, A. 2006. Aortic root disease after the Ross procedure. Curr Opin Cardiol, 21, 555-60. LUND, O., NIELSEN, S. L., ARILDSEN, H., ILKJAER, L. B. & PILEGAARD, H. K. 2000. Standard aortic St. Jude valve at 18 years: performance profile and determinants of outcome. Ann Thorac Surg, 69, 1459-65. MOKHLES, M. M., KORTKE, H., STIERLE, U., WAGNER, O., CHARITOS, E. I., BOGERS, A. J., GUMMERT, J., SIEVERS, H. H. & TAKKENBERG, J. J. 2011. Survival comparison of the Ross procedure and mechanical valve replacement with optimal self-management anticoagulation therapy: propensity-matched cohort study. Circulation, 123, 31-8. MOKHLES, M. M., RAJESWARAN, J., BEKKERS, J. A., BORSBOOM, G. J., ROOS-HESSELINK, J. W., STEYERBERG, E. W., BOGERS, A. J., TAKKENBERG, J. J. & BLACKSTONE, E. H. 2014. Capturing echocardiographic allograft valve function over time after allograft aortic valve or root replacement. J Thorac Cardiovasc Surg, 148, 1921-1928.e3. MOKHLES, M. M., RIZOPOULOS, D., ANDRINOPOULOU, E. R., BEKKERS, J. A., ROOS-HESSELINK, J. W., LESAFFRE, E., BOGERS, A. J. & TAKKENBERG, J. J. 2012. Autograft and pulmonary allograft performance in the second post-operative decade after the Ross procedure: insights from the Rotterdam Prospective Cohort Study. Eur Heart J, 33, 2213-24. MOSTELLER, R. D. 1987. Simplified calculation of body-surface area. N Engl J Med, 317, 1098. NAIDOO, R., PEARSE, B., TESAR, P. J., YAP, S. A., BARNETT, A. G. & FAYERS, T. 2014. Long-term outcomes following Medtronic Open Pivot valved conduit. J Heart Valve Dis, 23, 105-11. NISHIMURA, R. A., OTTO, C. M., BONOW, R. O., CARABELLO, B. A., ERWIN, J. P., 3RD, GUYTON, R. A., O'GARA, P. T., RUIZ, C. E., SKUBAS, N. J., SORAJJA, P., SUNDT, T. M., 3RD, THOMAS, J. D., ANDERSON, J. L., HALPERIN, J. L., ALBERT, N. M., BOZKURT, B., BRINDIS, R. G., CREAGER, M. A., CURTIS, L. H., DEMETS, D., GUYTON, R. A., HOCHMAN, J. S., KOVACS, R. J., OHMAN, E. M., PRESSLER, S. J., SELLKE, F. W., SHEN, W. K., STEVENSON, W. G. & YANCY, C. W. 2014. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Thorac Cardiovasc Surg, 148, e1-e132. NIWAYA, K., KNOTT-CRAIG, C. J., LANE, M. M., CHANDRASEKAREN, K., OVERHOLT, E. D. & ELKINS, R. C. 1999. Cryopreserved homograft valves in the pulmonary position: risk analysis for intermediate-term failure. J Thorac Cardiovasc Surg, 117, 141-6; discussion 46-7. NOTZOLD, A., HUPPE, M., SCHMIDTKE, C., BLOMER, P., UHLIG, T. & SIEVERS, H. H. 2001. Quality of life in aortic valve replacement: pulmonary autografts versus mechanical prostheses. J Am Coll Cardiol, 37, 1963-6. OTTO, C. M., BURWASH, I. G., LEGGET, M. E., MUNT, B. I., FUJIOKA, M., HEALY, N. L., KRAFT, C. D., MIYAKE-HULL, C. Y. & SCHWAEGLER, R. G. 1997. Prospective study of asymptomatic valvular aortic stenosis. Clinical, echocardiographic, and exercise predictors of outcome. Circulation, 95, 2262-70. OTTO, C. M., KUUSISTO, J., REICHENBACH, D. D., GOWN, A. M. & O'BRIEN, K. D. 1994. Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies. Circulation, 90, 844-53. OURY, J. H., MACKEY, S. K. & DURAN, C. M. 1999. Critical analysis of the Ross procedure: do its problems justify wider application? Semin Thorac Cardiovasc Surg, 11, 55-61. PELLIKKA, P. A., SARANO, M. E., NISHIMURA, R. A., MALOUF, J. F., BAILEY, K. R., SCOTT, C. G., BARNES, M. E. & TAJIK, A. J. 2005. Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up. Circulation, 111, 3290-5. PRASONGSUKARN, K., JAMIESON, W. R. & LICHTENSTEIN, S. V. 2005. Performance of bioprostheses and mechanical prostheses in age group 61-70 years. J Heart Valve Dis, 14, 501-8, 510-1; discussion 509. PRETORIUS, V., JONES, A., TAYLOR, D., COE, Y. & ROSS, D. B. 2008. Percutaneous valved stent repair of a failed homograft: implications for the Ross procedure. Can J Cardiol, 24, e54-5. RAANANI, E., YAU, T. M., DAVID, T. E., DELLGREN, G., SONNENBERG, B. D. & OMRAN, A. 2000. Risk factors for late pulmonary homograft stenosis after the Ross procedure. Ann Thorac Surg, 70, 1953-7. RAJA, S. G., BENEDETTO, U. & AMRANI, M. 2013. Aortic valve replacement through J-shaped partial upper sternotomy. J Thorac Dis, 5 Suppl 6, S662-8. REECE, T. B., WELKE, K. F., O'BRIEN, S., GRAU-SEPULVEDA, M. V., GROVER, F. L. & GAMMIE, J. S. 2014. Rethinking the ross procedure in adults. Ann Thorac Surg, 97, 175-81. RICHARDS, A. M., NICHOLLS, M. G., IKRAM, H., HAMILTON, E. J. & RICHARDS, R. D. 1984. Syncope in aortic valvular stenosis. Lancet, 2, 1113-6. ROGER, V. L. & TAJIK, A. J. 1993. Progression of aortic stenosis in adults: new insights provided by Doppler echocardiography. J Heart Valve Dis, 2, 114-8. ROSS, D. N. 1962. Homograft replacement of the aortic valve. Lancet, 2, 487. RUEL, M., KULIK, A., LAM, B. K., RUBENS, F. D., HENDRY, P. J., MASTERS, R. G., BEDARD, P. & MESANA, T. G. 2005. Long-term outcomes of valve replacement with modern prostheses in young adults. Eur J Cardiothorac Surg, 27, 425-33; discussion 433. RYAN, W. H., PRINCE, S. L., CULICA, D. & HERBERT, M. A. 2011. The Ross procedure performed for aortic insufficiency is associated with increased autograft reoperation. Ann Thorac Surg, 91, 64-9; discussion 69-70. SANTINI, F., CASALI, G., VISCARDI, F., FAVARO, A., LUCIANI, G. B., PENTIRICCI, S., LUSINI, M., ROSSI, A. & MAZZUCCO, A. 2002. The CarboMedics prosthetic heart valve: experience with 1,084 implants. J Heart Valve Dis, 11, 121-6; discussion 27. SCHMIDTKE, C., DAHMEN, G., GRAF, B. & SIEVERS, H. H. 2007. Pulmonary homograft muscle reduction to reduce the risk of homograft stenosis in the Ross procedure. J Thorac Cardiovasc Surg, 133, 190-5. SCHMIDTKE, C., HUPPE, M., BERNDT, S., NOTZOLD, A. & SIEVERS, H. H. 2001. [Quality of life after aortic valve replacement. Self-management or conventional anticoagulation therapy after mechanical valve replacement plus pulmonary autograft]. Z Kardiol, 90, 860-6. SIEVERS, H. H. 2002. [Status of aortic valve reconstruction and Ross operation in aortic valve diseases]. Herz, 27, 435-44. SIEVERS, H. H., STIERLE, U., CHARITOS, E. I., HANKE, T., GORSKI, A., MISFELD, M. & BECHTEL, M. 2010a. Fourteen years' experience with 501 subcoronary Ross procedures: surgical details and results. J Thorac Cardiovasc Surg, 140, 816-22, 822.e1-5. SIEVERS, H. H., STIERLE, U., CHARITOS, E. I., HANKE, T., MISFELD, M., MATTHIAS BECHTEL, J. F., GORSKI, A., FRANKE, U. F., GRAF, B., ROBINSON, D. R., BOGERS, A. J., DODGE-KHATAMI, A., BOEHM, J. O., REIN, J. G., BOTHA, C. A., LANGE, R., HOERER, J., MORITZ, A., WAHLERS, T., BREUER, M., FERRARI-KUEHNE, K., HETZER, R., HUEBLER, M., ZIEMER, G., TAKKENBERG, J. J. & HEMMER, W. 2010b. Major adverse cardiac and cerebrovascular events after the Ross procedure: a report from the German-Dutch Ross Registry. Circulation, 122, S216-23. SIEVERS, H. H., STIERLE, U., CHARITOS, E. I., TAKKENBERG, J. J., HORER, J., LANGE, R., FRANKE, U., ALBERT, M., GORSKI, A., LEYH, R. G., RISO, A., SACHWEH, J., MORITZ, A., HETZER, R. & HEMMER, W. 2015. A multicentre evaluation of the autograft procedure for young patients undergoing aortic valve replacement: update on the German Ross Registrydagger. Eur J Cardiothorac Surg. SLIWA, K., CARRINGTON, M., MAYOSI, B. M., ZIGIRIADIS, E., MVUNGI, R. & STEWART, S. 2010. Incidence and characteristics of newly diagnosed rheumatic heart disease in urban African adults: insights from the heart of Soweto study. Eur Heart J, 31, 719-27. SMEDIRA, N. G., BLACKSTONE, E. H., ROSELLI, E. E., LAFFEY, C. C. & COSGROVE, D. M. 2006. Are allografts the biologic valve of choice for aortic valve replacement in nonelderly patients? Comparison of explantation for structural valve deterioration of allograft and pericardial prostheses. J Thorac Cardiovasc Surg, 131, 558-564.e4. STELZER, P. & ELKINS, R. C. 1987. Pulmonary autograft: an American experience. J Card Surg, 2, 429-33. STELZER, P., JONES, D. J. & ELKINS, R. C. 1989. Aortic root replacement with pulmonary autograft. Circulation, 80, Iii209-13. STELZER, P., WEINRAUCH, S. & TRANBAUGH, R. F. 1998. Ten years of experience with the modified Ross procedure. J Thorac Cardiovasc Surg, 115, 1091-100. STEWART, B. F., SISCOVICK, D., LIND, B. K., GARDIN, J. M., GOTTDIENER, J. S., SMITH, V. E., KITZMAN, D. W. & OTTO, C. M. 1997. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol, 29, 630-4. SWINKELS, B. M., DE MOL, B. A., KELDER, J. C., VERMEULEN, F. E. & TEN BERG, J. M. 2015. Long-term bleeding events after mechanical aortic valve replacement in patients under the age of 60. Neth Heart J, 23, 111-5. TAKKENBERG, J. J., KLIEVERIK, L. M., SCHOOF, P. H., VAN SUYLEN, R. J., VAN HERWERDEN, L. A., ZONDERVAN, P. E., ROOS-HESSELINK, J. W., EIJKEMANS, M. J., YACOUB, M. H. & BOGERS, A. J. 2009. The Ross procedure: a systematic review and meta-analysis. Circulation, 119, 222-8. TASCA, G., BRUNELLI, F., CIRILLO, M., DALLATOMBA, M., MHAGNA, Z., TROISE, G. & QUAINI, E. 2005. Impact of valve prosthesis-patient mismatch on left ventricular mass regression following aortic valve replacement. Ann Thorac Surg, 79, 505-10. TASCA, G., MHAGNA, Z., PEROTTI, S., CENTURINI, P. B., SABATINI, T., AMADUCCI, A., BRUNELLI, F., CIRILLO, M., DALLA TOMBA, M., QUAINI, E., TROISE, G. & PIBAROT, P. 2006. Impact of prosthesis-patient mismatch on cardiac events and midterm mortality after aortic valve replacement in patients with pure aortic stenosis. Circulation, 113, 570-6. THADEN, J. J., NKOMO, V. T. & ENRIQUEZ-SARANO, M. 2014. The global burden of aortic stenosis. Prog Cardiovasc Dis, 56, 565-71. UNGERLEIDER, R. M., OOTAKI, Y., SHEN, I. & WELKE, K. F. 2010. Modified Ross procedure to prevent autograft dilatation. Ann Thorac Surg, 90, 1035-7; discussion 1037. UYSAL, F., BOSTAN, O. M., SIGNAK, I. S., SEMIZEL, E. & CIL, E. 2013. Evaluation of subvalvular aortic stenosis in children: a 16-year single-center experience. Pediatr Cardiol, 34, 1409-14. VAHANIAN, A. & IUNG, B. 2012. The new ESC/EACTS guidelines on the management of valvular heart disease. Arch Cardiovasc Dis, 105, 465-7. VAN GELDORP, M. W., ERIC JAMIESON, W. R., KAPPETEIN, A. P., YE, J., FRADET, G. J., EIJKEMANS, M. J., GRUNKEMEIER, G. L., BOGERS, A. J. & TAKKENBERG, J. J. 2009. Patient outcome after aortic valve replacement with a mechanical or biological prosthesis: weighing lifetime anticoagulant-related event risk against reoperation risk. J Thorac Cardiovasc Surg, 137, 881-6, 886e1-5. VAN GELDORP, M. W., HEUVELMAN, H. J., KAPPETEIN, A. P., BUSSCHBACH, J. J., TAKKENBERG, J. J. & BOGERS, A. J. 2013. The effect of aortic valve replacement on quality of life in symptomatic patients with severe aortic stenosis. Neth Heart J, 21, 28-35. VARADARAJAN, P., PATEL, R., TURK, R., KAMATH, A. R., SAMPATH, U., KHANDHAR, S. & PAI, R. G. 2013. Etiology impacts survival in patients with severe aortic regurgitation: results from a cohort of 756 patients. J Heart Valve Dis, 22, 42-9. WALTHER, T., FALK, V., LANGEBARTELS, G., KRUGER, M., BERNHARDT, U., DIEGELER, A., GUMMERT, J., AUTSCHBACH, R. & MOHR, F. W. 1999. Prospectively randomized evaluation of stentless versus conventional biological aortic valves: impact on early regression of left ventricular hypertrophy. Circulation, 100, Ii6-10. WEIMAR, T., CHARITOS, E. I., LIEBRICH, M., ROSER, D., TZANAVAROS, I., DOLL, N. & HEMMER, W. B. 2014. Quo vadis pulmonary autograft--the ross procedure in its second decade: a single-center experience in 645 patients. Ann Thorac Surg, 97, 167-74. WEIMAR, T., ROSER, D., LIEBRICH, M., HORKE, A., DOLL, N. & HEMMER, W. B. 2013. Strategies for biological heart valve replacement: stentless xenografts fail to evolve into an alternative pulmonary valve substitute in a Ross procedure. Biotechnol J, 8, 345-51. WILSON, W. M., GRIGG, L. E., GORELIK, A. & SKILLINGTON, P. 2014. Long term follow-up after aortic valve replacement (Ross procedure): echocardiographic determinants of ventricular recovery. Heart Lung Circ, 23, 132-43. YACOUB, M. H. & COHN, L. H. 2004a. Novel approaches to cardiac valve repair: from structure to function: Part I. Circulation, 109, 942-50. YACOUB, M. H. & COHN, L. H. 2004b. Novel approaches to cardiac valve repair: from structure to function: Part II. Circulation, 109, 1064-72. YACOUB, M. H., EL-HAMAMSY, I., SIEVERS, H. H., CARABELLO, B. A., BONOW, R. O., STELZER, P., DA COSTA, F. D., SCHAFERS, H. J., SKILLINGTON, P., CHARITOS, E. I., LUCIANI, G. B. & TAKKENBERG, J. J. 2014. Under-use of the Ross operation--a lost opportunity. Lancet, 384, 559-60. YACOUB, M. H., KLIEVERIK, L. M., MELINA, G., EDWARDS, S. E., SARATHCHANDRA, P., BOGERS, A. J., SQUARCIA, U., SANI, G., VAN HERWERDEN, L. A. & TAKKENBERG, J. J. 2006. An evaluation of the Ross operation in adults. J Heart Valve Dis, 15, 531-9.
Lizenz:	Urheberrechtsschutz
Bezug:	01.05.2013 bis 31.05.2016
Fachbereich / Einrichtung:	Medizinische Fakultät
Dokument erstellt am:	10.06.2016
Dateien geändert am:	10.06.2016
Promotionsantrag am:	30.06.2014
Datum der Promotion:	31.05.2016