Dokument: Pharmaceutical Care of Adolescents with Type 1 Diabetes Mellitus:
| Titel: | Pharmaceutical Care of Adolescents with Type 1 Diabetes Mellitus: | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=35510 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20151021-112208-6 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | PharmD Obarcanin, Emina [Autor] | |||||||
| Dateien: |
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| Beitragende: | Prof. Dr. Läer, Stephanie [Gutachter] Prof. Dr. Breitkreutz, Jörg [Gutachter] | |||||||
| Dewey Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit | |||||||
| Beschreibung: | Background:Physiological and psychological changes during puberty and low adherence to therapy regimens during adolescence result in a deterioration of glycemic control, increased morbidity and premature mortality. The benefit of pharmaceutical care (PhC) in adults with T2DM has been widely explored; however, evidence in adolescents with T1DM remains scarce. Objective: to evaluate the impact of PhC in T1DM adolescents on important clinical outcomes (e.g.HbA1c levels, incidence of severe hypoglycemia). Setting: Helios Pediatric Clinic and 12 community pharmacies, in Krefeld area, Germany, and the University Pediatric Clinic in Sarajevo, Bosnia-Herzegovina. Methods: this was a randomized, controlled, multicenter study including 68 adolescents with T1DM. Patients were randomly assigned to the intervention (n = 40) or control (n = 28) groups. Intervention patients received monthly PhC for 6 months and additional phone calls. Control patients received usual care. Main outcome measures: the change from baseline in HbA1c and the number of severe hypoglycemia events in the intervention and control groups. Additional outcomes, in the intervention group, were non-severe hypoglycemic events, patient wellbeing, satisfaction with PhC, DRPs and adherence to pediatric guidelines. Results: this study showed a significantly greater improvement from baseline in HbA1c in the intervention group versus the control group after 6 months (change from baseline −0.54 vs. +0.32 %, p = 0.0075), with an even more pronounced improvement after only 3 months (−1.09 vs. +0.23%, p = 0.00002). There was no significant between-group difference in the number of severe hypoglycemia events. Conclusion: improved clinical outcomes provide new evidence that PhC adds value in the management of T1DM adolescents. However, optimal methods of achieving sustained, long-term improvements require further study. | |||||||
| Lizenz: |  Urheberrechtsschutz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät » WE Pharmazie » Klinische Pharmazie und Pharmakotherapie | |||||||
| Dokument erstellt am: | 21.10.2015 | |||||||
| Dateien geändert am: | 21.10.2015 | |||||||
| Promotionsantrag am: | 14.10.2014 | |||||||
| Datum der Promotion: | 10.11.2014 |
