| Titel: | Novel insight into G-protein mediated cellular Signaling in endothelial biology and chronobiology |
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=33100 |
| URN (NBN): | urn:nbn:de:hbz:061-20150108-105648-5 |
| Kollektion: | Dissertationen |
| Sprache: | Englisch |
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation |
| Medientyp: | Text |
| Autor: | M.Sc. Singh, Madhurendra [Autor]
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| Dateien: | |
| Dewey Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik » 570 Biowissenschaften; Biologie |
| Beschreibung: | Heptahelical receptors or GPCR (G-protein-coupled receptors) comprise the largest family of transmembrane receptors involved in intracellular signal transduction. The subgroup of Gi-proteins links GiPCR with adenylyl cyclases and phosphoinositide 3-kinases as major intracellular effectors. The major and highly homologous Gαi isoforms Gαi2 and Gαi3 are ubiquitously expressed with Gαi2 being typically present at much higher protein levels as Gαi3. The generation and phenotypic characterization of mouse lines with targeted loss-of-function mutations revealed isoform-specific as well as redundant biological functions of Gαi2 and Gαi3. Here, a further molecular and cell biological phenotyping of Gαi-deficient mouse lines was performed. The results presented in Part I suggest a novel isoform-specific regulatory role of Gαi3 in sexual-dimorphic, circadian clock gene expression and function in the liver. Part II of this thesis describes a novel antiapoplectic function of endothelial Gαi2 that is linked to vasotonus regulation and pathophysiologically associated with a cerebral stroke and ischemia phenotype
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| Lizenz: | 
Urheberrechtsschutz
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| Fachbereich / Einrichtung: | Medizinische Fakultät » Institute » Institut für Biochemie und Molekularbiologie II |
| Dokument erstellt am: | 08.01.2015 |
| Dateien geändert am: | 08.01.2015 |
| Promotionsantrag am: | 23.06.2014 |
| Datum der Promotion: | 27.10.2014 |
