Dokument: Lipase Catalyzed Aminolysis as An Entry to Consecutive Multicomponent Reactions.
| Titel: | Lipase Catalyzed Aminolysis as An Entry to Consecutive Multicomponent Reactions. | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=30763 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20140925-145817-6 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | Ms. Hassan, Sidra [Autor] | |||||||
| Dateien: |
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| Beitragende: | Prof. Dr. Müller, Thomas J. J. [Betreuer/Doktorvater] Prof. Dr. Pietruszka, Jörg [Gutachter] | |||||||
| Dewey Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik » 540 Chemie | |||||||
| Beschreibung: | One of the hallmarks of multicomponent syntheses is the attainment of complexity in the target molecules using relatively simpler starting materials. Since the benign and selective nature of enzyme catalysis offers the possibility to introduce various sensitive functionalities and hence complexity in a product, therefore the concept of incorporation of biocatalysis in multicomponent syntheses was considered worth exploring. In present work, the entry to mutlicomponent syntheses comprises of Candida antarctica lipase B (CAL-B) catalyzed aminolysis of ester substrates furnishing corresponding propargylamides that not only individually act as irreversible cysteine protease inhibitors but can also successfully engage further in cycloaddition and coupling reactions. Thus the prime focus is to achieve the synergy between chemical catalysis (Cu, Pd) following the CAL-B catalyzed aminolysis, for the development of one-pot syntheses of such cycloadded and coupled products. This approach led to the development of three component one-pot synthesis of amide ligated 1,2,3-triazoles that have been established as peptidomimetics in their action, and to the one-pot palladium catalyzed Sonogashira coupling sequence | |||||||
| Lizenz: |  Urheberrechtsschutz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät » WE Chemie » Organische Chemie und Makromolekulare Chemie | |||||||
| Dokument erstellt am: | 25.09.2014 | |||||||
| Dateien geändert am: | 25.09.2014 | |||||||
| Promotionsantrag am: | 23.06.2014 | |||||||
| Datum der Promotion: | 09.07.2014 |
