Dokument: Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) aktiviert β1-Integrin via CD63 und fördert Migration und Adhäsion hämatopoietischer Stamm- und Progenitorzellen
| Titel: | Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) aktiviert β1-Integrin via CD63 und fördert Migration und Adhäsion hämatopoietischer Stamm- und Progenitorzellen | |||||||
| Weiterer Titel: | The tissue inhibitor of metalloproteinases-1 improves migration and adhesion of hematopoietic stem and progenitor cells | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=29560 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20141016-101113-2 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Deutsch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | Wilk, Christian Matthias [Autor] | |||||||
| Dateien: |
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| Beitragende: | Prof. Dr. Haas, Rainer [Gutachter] Prof. Dr. Meisel, Roland [Gutachter] | |||||||
| Stichwörter: | TIMP-1, CD63, Transplantation, Homing, Engraftment | |||||||
| Dewey Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit | |||||||
| Beschreibung: | Homing and engraftment of hematopoietic stem and progenitor cells (HSPCs) during bone marrow transplantation are critically dependent on integrins such as b1-integrin. In the present study, we show that b1-integrin and the tetraspanin CD63 form a cell surface receptor complex for the soluble serum protein tissue inhibitor of metalloproteinases-1 (TIMP-1) on human CD34+ HSPCs. Through binding to this receptor complex, TIMP-1 activates b1-integrin, increases adhesion and migration of human CD34+ cells, and protects these cells from induced apoptosis. TIMP-1 stimulation in murine bone marrow mononuclear cells also promotes migration and adhesion; this is associated with augmented homing of murine mononuclear cells and of murine LSK+ cells during bone marrow transplantation. These results not only indicate that TIMP-1 is conducive to HSPC homing; they also identify CD63 and b1- integrin as a TIMP-1 receptor complex on HSPCs. | |||||||
| Lizenz: |  Urheberrechtsschutz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 16.10.2014 | |||||||
| Dateien geändert am: | 16.10.2014 | |||||||
| Promotionsantrag am: | 23.05.2013 | |||||||
| Datum der Promotion: | 29.04.2014 |
