Dokument: AIRBORNE NICKEL EXPOSURE: CAN IT INDUCE NICKEL SENSITIZATION?

Titel:AIRBORNE NICKEL EXPOSURE: CAN IT INDUCE NICKEL SENSITIZATION?
Weiterer Titel:A POPULATION BASED STUDY WITH 6-YEAR-OLD CHILDREN
URL für Lesezeichen:https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=24125
URN (NBN):urn:nbn:de:hbz:061-20130312-130602-4
Kollektion:Dissertationen
Sprache:Englisch
Dokumententyp:Wissenschaftliche Abschlussarbeiten » Dissertation
Medientyp:Text
Autor:Dr.med. Mann, Eugen [Autor]
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Dateien vom 12.03.2013 / geändert 12.03.2013
Beitragende:Prof. Dr. Ranft, Ulrich [Gutachter]
Prof. Dr. Homey, Bernhard [Gutachter]
Stichwörter:Sensitization; airborne exposure; ambient air; nickel hypersensitivity; environmental; patch test; children.
Dewey Dezimal-Klassifikation:600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit
Beschreibungen:Nickelexposition in der Luft: kann sie eine Nickelsensibilisierung hervorrufen? Eine populationsbezogene Studie über TH1-zellvermittelte Immunantwort mit Kindern im Einschulungsalter.

Die vorliegende Studie hatte den Zweck, den Zusammenhang zwischen der Nickelbelastung in Außenluft und der Ausprägung der gesundheitsrelevanten Faktoren – gemessen u.a. in Prävalenz der Nickelsensibilisierung, vorwiegend TH1-zellvermittelte Immunreaktion - bei sechsjährigen Kindern, die in unmittelbarer Nähe der Industriegebiete in der Bundesrepublik Deutschland wohnen, zu evaluieren. Belastung und Gesundheitseffekte wurden bei Kindern in Schulanfängeralter ermittelt. Der Wohnsitz der Studienteilehmer war in der Nähe der Industriequellen der drei unterschiedlichen „Hot Spots“ in NRW (Dortmund-Hörde, Duisburg-Nord und Duisburg-Süd), in einem ländlichen Gebiet ohne unmittelbarer industrieller Belastung (Stadt Borken in Westfalen), das als Referenzareal für die „Hot Spot“ dienen sollte, sowie in den Vergleichsarealen in anderen Gebieten Deutschlands: einer Stadt in Bayern (Augsburg) und einer Stadt in den neuen Bundesländern (Halle). Die Querschnittstudie wurde im Zeitraum zwischen März und Juni 2000 durchgeführt. Die Erfassung der Belastung beinhaltete Modellierung von Außenluftdaten und Messung der Nickelaufnahme mit Trinkwasser als Außenbelastung sowie die Human Biomonitoring (HBM), i.e. Erfassung der Nickelwerte in Morgenurin als innere Belastung. Gesundheitseffekte wurden mittels eines Fragebogens, des CAP-FEIA-Systems sowie des Epikutantests (ECT) erfasst. Der Einfluss der Belastungsfaktoren auf Nickelsensibilisierung wurde mittels linearer und logistischer Regressionsanalyse gemessen. Die wichtigen Ergebnisse waren wie folgt: die beobachtete Nickelsensibilisierungsprävalenz variierte in den Studienzentren zwischen 5.0% (Dortmund-Horde) und 38.1% (Halle). Kinder, die im „Hot Spot“ Dortmund-Hörde wohnten (v.a. erhöhte Chrom- und Nickelwerte in der Außenluft aus Stahlwerk), zeigten erhöhte Prävalenzen verschiedener Allergiesymptome und Sensibilisierungen, während Kinder, deren Wohnsitz in Duisburg-Nord lag (Kokerei, Stahlwerk, Hochofen und Sinteranlage), u.a. erhöhte akute Nickelkonzentrationen in Urin aufwiesen. In dieser Studie wurde ein positiver signifikanter Zusammenhang zwischen Nickelsensibilisierung und der akuten inneren Nickelbelastung gemessen in Nickelkonzentration im Morgenurin beobachtet. Des Weiteren, wurde ein tendenzieller, jedoch signifikanter Zusammenhang zwischen Nickelwerten in der Außenluft und Nickelkonzentration in Urin festgestellt. Zusammenfassend lässt sich festhalten, dass erhöhte Nickelbelastung in der Außenluft zu einem gewissen Grad zur Entstehung der Nickelsensibilisierung beitragen kann. Weitere Studien sind notwendig, um Hinweise dieser Studie in größeren Kollektiven in anderen Arealen mit bekannter erhöhter Nickelbelastung in Außenluft zu verifizieren.

The present study aimed to evaluate an association between exposure to nickel in ambient air and the health outcome measured in prevalence of nickel sensitization (prevalently TH1-cell-mediated delayed immune response (Type IV)) in children living close to industrial sources in Germany. Exposure and health outcome were assessed in children at school-beginner age residing in the vicinity of industrial sources of three different hot spots in the State of North Rhine Westphalia (Dortmund Hörde, Duisburg North and Duisburg South), in a rural town without nearby point sources of nickel (Borken), which served as a reference area for the hot spots, and in the comparison areas in other parts of Germany: a city in the State of Bavaria (Augsburg) and a city in the former socialist German Democratic Republic (Halle). The cross-sectional study was conducted between March and June 2000. Exposure assessment comprised modelling of the ambient air quality data and measuring of nickel uptake in tap water (external exposures) and human biomonitoring (HBM), i.e. the measurement of nickel in urine (internal exposure). Health outcome was determined by a questionnaire, a Pharmacia CAP-FEIA system and an epicutaneous patch test (ECT). The influence of exposure variables on nickel sensitization was measured by means of linear and logistic regression analysis. The most striking results were as follows. Children living in the hot spot Dortmund Hörde (increased chromium and nickel levels in ambient air from a steel mill) revealed a peerless prevalence of diverse allergic symptoms and sensitizations, whereas children residing in Duisburg North (a coking plant, sintering plant, steel mill and blast furnace) had elevated current nickel concentrations in urine. Sensitization to nickel in the present study was positively associated with the current internal nickel exposure, and a weak positive significant association between nickel levels in ambient air and in urine was observed. It is concluded that, despite improvements in the general air quality during the last decades, living in the proximity of industrial sources results to some extent in increased internal nickel exposure and in the nickel sensitization.
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Fachbereich / Einrichtung:Medizinische Fakultät
Dokument erstellt am:12.03.2013
Dateien geändert am:12.03.2013
Promotionsantrag am:20.05.2011
Datum der Promotion:18.01.2013
english
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