Dokument: Induktion der Cyclooxygenase 2-Expression durch UV-Strahlung über p38-MAP-Kinase-vermittelte mRNA-Stabilisierung
| Titel: | Induktion der Cyclooxygenase 2-Expression durch UV-Strahlung über p38-MAP-Kinase-vermittelte mRNA-Stabilisierung | |||||||
| Weiterer Titel: | Induction of Cyclooxygenase 2-expression by UV-irradiation via p38-MAP-Kinase-transmitted mRNA-stabilization | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=16020 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20101021-150851-5 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Deutsch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | Fugmann, Dominik [Autor] | |||||||
| Dateien: |
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| Stichwörter: | Cyclooxygenase 2 COX-2 p38 MAP-Kinase UV HaCat Keratinozyten mRNA-Stabilisierung | |||||||
| Dewey Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften » 610 Medizin und Gesundheit | |||||||
| Beschreibung: | COX-2 hat zahlreiche physiologische Aufgaben im menschlichen Organismus, ist jedoch auch an einigen pathophysiologischen Prozessen beteiligt: So gibt es Hinweise auf tumorpromovierende und karzinogene Wirkung der COX-2. Da UV-Strahlung Hauttumoren verursachen kann, sollte in der vorliegenden Arbeit ein Zusammenhang zwischen den UV-Qualitäten UVA- und UVB-Strahlung und der COX-2-Expression in HaCat-Zellen, immortalisierten menschlichen Keratinozyten, näher untersucht werden. Als ein mögliches Bindeglied zwischen UV-Bestrahlung und COX-2-Expression wird unter anderem ein Mitglied aus der Familie der MAP-Kinasen vermutet: Die p38-MAP-Kinase, so dass auch ihre Rolle bei der COX-2-Expression in der vorliegenden Arbeit näher untersucht werden sollte.
Die vorliegende Arbeit zeigt, dass UVB-Bestrahlung – im Gegensatz zu UVA-Bestrahlung – zu einer deutlichen Induktion der COX-2 führt, und zwar sowohl auf RNA-, als auch auf Proteinebene. Als Vermittler dieser Induktion wurde die p38-MAP-Kinase identifiziert: Eine Hemmung derselben vor Bestrahlung unterdrückte die vermehrte COX-2-Expression. Wesentlich zur vermehrten COX-2-Expression trägt bei, dass UVB-Bestrahlung zu einer langanhaltenden COX-2-mRNA-Stabilisierung führt – wohingegen eine Stabilisierung nach UVA-Bestrahlung nur sehr geringfügig nachzuweisen war. Die Stabilisierung ließ sich verhindern, indem die p38-MAPK vor Bestrahlung gehemmt wurde. Insgesamt konnte in der vorliegenden Arbeit also gezeigt werden, dass – im Gegensatz zur UVA-Strahlung – vor allem UVB-Strahlung eine vermehrte COX-2-Expression bewirkt, und zwar durch Stabilisierung der COX-2-mRNA. Diese wird vermittelt durch eine Aktivierung der p38-MAP-Kinase. | |||||||
| Quelle: | Anderson KE, Johnson TW, Lazovich D and Folsom AR. (2002). J Natl Cancer Inst, 94, 1168-1171.
Appleby SB, Ristimaki A, Neilson K, Narko K and Hla T. (1994). Biochem J, 302 ( Pt 3), 723-727. Armstrong BK and Kricker A. (2001). J Photochem Photobiol B, 63, 8-18. Assefa Z, Garmyn M, Bouillon R, Merlevede W, Vandenheede JR and Agostinis P. (1997). J Invest Dermatol, 108, 886-891. Bachelor MA, Cooper SJ, Sikorski ET and Bowden GT. (2005). Mol Cancer Res, 3, 90-99. Bachelor MA, Silvers AL and Bowden GT. (2002). Oncogene, 21, 7092-7099. Bagrodia S, Derijard B, Davis RJ and Cerione RA. (1995). J Biol Chem, 270, 27995-27998. Barnes NL, Warnberg F, Farnie G, White D, Jiang W, Anderson E and Bundred NJ. (2007). Br J Cancer, 96, 575-582. Becerra CR, Frenkel EP, Ashfaq R and Gaynor RB. (2003). Int J Cancer, 105, 868-872. Beelman CA and Parker R. (1995). Cell, 81, 179-183. Bender K, Blattner C, Knebel A, Iordanov M, Herrlich P and Rahmsdorf HJ. (1997). J Photochem Photobiol B, 37, 1-17. Bernstein P and Ross J. (1989). Trends Biochem Sci, 14, 373-377. Blank JL, Gerwins P, Elliott EM, Sather S and Johnson GL. (1996). J Biol Chem, 271, 5361-5368. Blattner C, Kannouche P, Litfin M, Bender K, Rahmsdorf HJ, Angulo JF and Herrlich P. (2000). Mol Cell Biol, 20, 3616-3625. Bode AM and Dong Z. (2003). Sci STKE, 2003, RE2. Bollig F, Winzen R, Kracht M, Ghebremedhin B, Ritter B, Wilhelm A, Resch K and Holtmann H. (2002). Eur J Biochem, 269, 5830-5839. Bomser JA. (2002). J Biochem Mol Toxicol, 16, 33-40. Boukamp P, Popp S, Altmeyer S, Hulsen A, Fasching C, Cremer T and Fusenig NE. (1997). Genes Chromosomes Cancer, 19, 201-214. Brannon TS, North AJ, Wells LB and Shaul PW. (1994). J Clin Invest, 93, 2230-2235. Brenneisen P, Sies H and Scharffetter-Kochanek K. (2002). Ann N Y Acad Sci, 973, 31-43. Brewer G. (1991). Mol Cell Biol, 11, 2460-2466. Brook M, Sully G, Clark AR and Saklatvala J. (2000). FEBS Lett, 483, 57-61. Buckman SY, Gresham A, Hale P, Hruza G, Anast J, Masferrer J and Pentland AP. (1998). Carcinogenesis, 19, 723-729. Burns K, Martinon F, Esslinger C, Pahl H, Schneider P, Bodmer JL, Di MF, French L and Tschopp J. (1998). J Biol Chem, 273, 12203-12209. Cadet J, Anselmino C, Douki T and Voituriez L. (1992). J Photochem Photobiol B, 15, 277-298. Canney PA, Machin MA and Curto J. (2006). Eur J Cancer, 42, 2751-2756. Carballo E, Lai WS and Blackshear PJ. (1998). Science, 281, 1001-1005. Casey JL, Koeller DM, Ramin VC, Klausner RD and Harford JB. (1989). EMBO J, 8, 3693-3699. Chandrasekharan S, Qiu TH, Alkharouf N, Brantley K, Mitchell JB and Liu ET. (2002). Mol Cell Biol, 22, 5235-5247. Chang HY, Nishitoh H, Yang X, Ichijo H and Baltimore D. (1998). Science, 281, 1860-1863. Chen CY, Gherzi R, Andersen JS, Gaietta G, Jurchott K, Royer HD, Mann M and Karin M. (2000). Genes Dev, 14, 1236-1248. Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M and Karin M. (2001a). Cell, 107, 451-464. Chen CY and Shyu AB. (1995). Trends Biochem Sci, 20, 465-470. Chen W and Bowden GT. (1999). Oncogene, 18, 7469-7476. Chen W, Dong Z, Valcic S, Timmermann BN and Bowden GT. (1999). Mol Carcinog, 24, 79-84. Chen W, Tang Q, Gonzales MS and Bowden GT. (2001b). Oncogene, 20, 3921-3926. Chulada PC, Thompson MB, Mahler JF, Doyle CM, Gaul BW, Lee C, Tiano HF, Morham SG, Smithies O and Langenbach R. (2000). Cancer Res, 60, 4705-4708. Chun KS, Akunda JK and Langenbach R. (2007). Cancer Res, 67, 2015-2021. Cobb MH. (1999). Prog Biophys Mol Biol, 71, 479-500. Cobb MH and Goldsmith EJ. (1995). J Biol Chem, 270, 14843-14846. Colville-Nash PR and Gilroy DW. (2001). BioDrugs, 15, 1-9. Comes F, Matrone A, Lastella P, Nico B, Susca FC, Bagnulo R, Ingravallo G, Modica S, Lo SG, Moschetta A, Guanti G and Simone C. (2007). Cell Death Differ, 14, 693-702. Couttet P, Fromont-Racine M, Steel D, Pictet R and Grange T. (1997). Proc Natl Acad Sci U S A, 94, 5628-5633. Crofford LJ. (1997). J Rheumatol Suppl, 49, 15-19. Dang CT, Dannenberg AJ, Subbaramaiah K, Dickler MN, Moasser MM, Seidman AD, D'Andrea GM, Theodoulou M, Panageas KS, Norton L and Hudis CA. (2004). Clin Cancer Res, 10, 4062-4067. Davies NM, Good RL, Roupe KA and Yanez JA. (2004). J Pharm Pharm Sci, 7, 217-226. Day DA and Tuite MF. (1998). J Endocrinol, 157, 361-371. de Gruijl FR, van Kranen HJ and Mullenders LH. (2001). J Photochem Photobiol B, 63, 19-27. Deacon K and Blank JL. (1999). J Biol Chem, 274, 16604-16610. Dean JL, Brook M, Clark AR and Saklatvala J. (1999). J Biol Chem, 274, 264-269. Dehlin E, Wormington M, Korner CG and Wahle E. (2000). EMBO J, 19, 1079-1086. Denkert C, Koch I, von Keyserlingk N, Noske A, Niesporek S, Dietel M and Weichert W. (2006). Mod Pathol, 19, 1261-1269. Denkert C, Weichert W, Pest S, Koch I, Licht D, Köbel M, Reles A, Sehouli J, Dietel M and Hauptmann S. (2004a). Cancer Res, 64, 189-195. Denkert C, Weichert W, Winzer KJ, Müller BM, Noske A, Niesporek S, Kristiansen G, Guski H, Dietel M and Hauptmann S. (2004b). Clin Cancer Res, 10, 5580-5586. Denkert C, Winzer KJ, Müller BM, Weichert W, Pest S, Kobel M, Kristiansen G, Reles A, Siegert A, Guski H and Hauptmann S. (2003). Cancer, 97, 2978-2987. Derijard B, Raingeaud J, Barrett T, Wu IH, Han J, Ulevitch RJ and Davis RJ. (1995). Science, 267, 682-685. Dhanasekaran N, Tsim ST, Dermott JM and Onesime D. (1998). Oncogene, 17, 1383-1394. Dixon DA, Tolley ND, King PH, Nabors LB, McIntyre TM, Zimmerman GA and Prescott SM. (2001). J Clin Invest, 108, 1657-1665. DuBois RN, Giardiello FM and Smalley WE. (1996a). Gastroenterol Clin North Am, 25, 773-791. DuBois RN, Shao J, Tsujii M, Sheng H and Beauchamp RD. (1996b). Cancer Res, 56, 733-737. El-Rayes BF, Zalupski MM, Manza SG, Rusin B, Ferris AM, Vaishampayan U, Heilbrun LK, Venkatramanamoorthy R, Shields AF and Philip PA. (2008). Cancer Chemother Pharmacol, 61, 283-289. El-Rayes BF, Zalupski MM, Shields AF, Ferris AM, Vaishampayan U, Heilbrun LK, Venkatramanamoorthy R, Adsay V and Philip PA. (2005). Invest New Drugs, 23, 583-590. Englaro W, Derijard B, Ortonne JP and Ballotti R. (1998). Oncogene, 16, 661-664. Fabi A, Metro G, Papaldo P, Mottolese M, Melucci E, Carlini P, Sperduti I, Russillo M, Gelibter A, Ferretti G, Tomao S, Milella M and Cognetti F. (2008). Cancer Chemother Pharmacol, 62, 717-725. Ferrari V, Valcamonico F, Amoroso V, Simoncini E, Vassalli L, Marpicati P, Rangoni G, Grisanti S, Tiberio GA, Nodari F, Strina C and Marini G. (2006). Cancer Chemother Pharmacol, 57, 185-190. Figueroa A, Cuadrado A, Fan J, Atasoy U, Muscat GE, Munoz-Canoves P, Gorospe M and Munoz A. (2003). Mol Cell Biol, 23, 4991-5004. Fischer SM, Lo HH, Gordon GB, Seibert K, Kelloff G, Lubet RA and Conti CJ. (1999). Mol Carcinog, 25, 231-240. Fischer SM, Pavone A, Mikulec C, Langenbach R and Rundhaug JE. (2007). Mol Carcinog, 46, 363-371. Franklin CC, Srikanth S and Kraft AS. (1998). Proc Natl Acad Sci U S A, 95, 3014-3019. Freshney NW, Rawlinson L, Guesdon F, Jones E, Cowley S, Hsuan J and Saklatvala J. (1994). Cell, 78, 1039-1049. Fu JY, Masferrer JL, Seibert K, Raz A and Needleman P. (1990). J Biol Chem, 265, 16737-16740. Fusenig NE and Boukamp P. (1998). Mol Carcinog, 23, 144-158. Ganiatsas S, Kwee L, Fujiwara Y, Perkins A, Ikeda T, Labow MA and Zon LI. (1998). Proc Natl Acad Sci U S A, 95, 6881-6886. Gao M, Fritz DT, Ford LP and Wilusz J. (2000). Mol Cell, 5, 479-488. Gao M, Wilusz CJ, Peltz SW and Wilusz J. (2001). EMBO J, 20, 1134-1143. Gibson LL, Hahner L, Osborne-Lawrence S, German Z, Wu KK, Chambliss KL and Shaul PW. (2005). Circ Res, 96, 518-525. Goedert M, Cuenda A, Craxton M, Jakes R and Cohen P. (1997). EMBO J, 16, 3563-3571. Gorospe M, Wang X and Holbrook NJ. (1998). Mol Cell Biol, 18, 1400-1407. Gout S, Morin C, Houle F and Huot J. (2006). Cancer Res, 66, 9117-9124. Grether-Beck S, Buettner R and Krutmann J. (1997). Biol Chem, 378, 1231-1236. Guan Z, Buckman SY, Pentland AP, Templeton DJ and Morrison AR. (1998). J Biol Chem, 273, 12901-12908. Hanks SK and Hunter T. (1995). FASEB J, 9, 576-596. Harris RC and Breyer MD. (2006). Clin J Am Soc Nephrol, 1, 236-245. Harris RC, McKanna JA, Akai Y, Jacobson HR, DuBois RN and Breyer MD. (1994). J Clin Invest, 94, 2504-2510. Harris RE, Alshafie GA, Abou-Issa H and Seibert K. (2000). Cancer Res, 60, 2101-2103. Harris RE, Beebe-Donk J and Alshafie GA. (2007). Int J Biol Sci, 3, 328-334. Hawkey CJ. (2002). Gut, 50 Suppl 3, III25-III30. Hempel SL, Monick MM, He B, Yano T and Hunninghake GW. (1994). J Biol Chem, 269, 32979-32984. Hirai S, Izawa M, Osada S, Spyrou G and Ohno S. (1996). Oncogene, 12, 641-650. Hla T and Maciag T. (1991). J Biol Chem, 266, 24059-24063. Hla T and Neilson K. (1992). Proc Natl Acad Sci U S A, 89, 7384-7388. Hutchison M, Berman KS and Cobb MH. (1998). J Biol Chem, 273, 28625-28632. Ichijo H, Nishida E, Irie K, Ten DP, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K and Gotoh Y. (1997). Science, 275, 90-94. Iordanov MS, Choi RJ, Ryabinina OP, Dinh TH, Bright RK and Magun BE. (2002). Mol Cell Biol, 22, 5380-5394. Jacobs EJ, Connell CJ, Rodriguez C, Patel AV, Calle EE and Thun MJ. (2004). J Natl Cancer Inst, 96, 524-528. Jarvis B and Figgitt DP. (2003). Am J Clin Dermatol, 4, 203-213. Jiang Y, Chen C, Li Z, Guo W, Gegner JA, Lin S and Han J. (1996). J Biol Chem, 271, 17920-17926. Jun SS, Chen Z, Pace MC and Shaul PW. (1999). Circ Res, 84, 193-200. Kabuyama Y, Homma MK, Kurosaki T and Homma Y. (2002). Eur J Biochem, 269, 664-670. Kargman SL, O'Neill GP, Vickers PJ, Evans JF, Mancini JA and Jothy S. (1995). Cancer Res, 55, 2556-2559. Katiyar SK and Meeran SM. (2007). Free Radic Biol Med, 42, 299-310. Kaur BS, Khamnehei N, Iravani M, Namburu SS, Lin O and Triadafilopoulos G. (2002). Gastroenterology, 123, 60-67. Kawamori T, Rao CV, Seibert K and Reddy BS. (1998). Cancer Res, 58, 409-412. Kinoshita T, Takahashi Y, Sakashita T, Inoue H, Tanabe T and Yoshimoto T. (1999). Biochim Biophys Acta, 1438, 120-130. Kis B, Snipes JA and Busija DW. (2005). J Pharmacol Exp Ther, 315, 1-7. Klotz LO, Briviba K and Sies H. (1997). FEBS Lett, 408, 289-291. Klotz LO, Holbrook NJ and Sies H. (2001). Curr Probl Dermatol, 29, 95-113. Klotz LO, Pellieux C, Briviba K, Pierlot C, Aubry JM and Sies H. (1999). Eur J Biochem, 260, 917-922. Körner CG and Wahle E. (1997). J Biol Chem, 272, 10448-10456. Krutmann J. (1998). Eur J Dermatol, 8, 200-202. Kuwamura H, Tominaga K, Shiota M, Ashida R, Nakao T, Sasaki E, Watanabe T, Fujiwara Y, Oshitani N, Higuchi K, Ichijo H, Arakawa T and Iwao H. (2007). Oncol Rep, 17, 781-786. Labayle D, Fischer D, Vielh P, Drouhin F, Pariente A, Bories C, Duhamel O, Trousset M and Attali P. (1991). Gastroenterology, 101, 635-639. Lai WS, Carballo E, Strum JR, Kennington EA, Phillips RS and Blackshear PJ. (1999). Mol Cell Biol, 19, 4311-4323. Langenbach R, Loftin C, Lee C and Tiano H. (1999). Biochem Pharmacol, 58, 1237-1246. Larkins TL, Nowell M, Singh S and Sanford GL. (2006). BMC Cancer, 6, 181. Laroia G, Cuesta R, Brewer G and Schneider RJ. (1999). Science, 284, 499-502. Lasa M, Mahtani KR, Finch A, Brewer G, Saklatvala J and Clark AR. (2000). Mol Cell Biol, 20, 4265-4274. Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW and . (1994). Nature, 372, 739-746. Lee SH, Soyoola E, Chanmugam P, Hart S, Sun W, Zhong H, Liou S, Simmons D and Hwang D. (1992). J Biol Chem, 267, 25934-25938. Levine L. (1981). Adv Cancer Res, 35, 49-79. Levy NS, Chung S, Furneaux H and Levy AP. (1998). J Biol Chem, 273, 6417-6423. Li Z, Jiang Y, Ulevitch RJ and Han J. (1996). Biochem Biophys Res Commun, 228, 334-340. Lim L, Manser E, Leung T and Hall C. (1996). Eur J Biochem, 242, 171-185. Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL and Karin M. (1995). Science, 268, 286-290. Loflin P, Chen CY and Shyu AB. (1999). Genes Dev, 13, 1884-1897. Luo C, Kallajoki M, Gross R, Mulari M, Teros T, Ylinen L, Makinen M, Laine J and Simell O. (2002). Cell Tissue Res, 310, 169-175. Ma WJ, Cheng S, Campbell C, Wright A and Furneaux H. (1996). J Biol Chem, 271, 8144-8151. Mahns A, Melchheier I, Suschek CV, Sies H and Klotz LO. (2003). Free Radic Res, 37, 391-397. Mahns A, Wolber R, Stab F, Klotz LO and Sies H. (2004). Photochem Photobiol Sci, 3, 257-262. Marnett LJ. (1992). Cancer Res, 52, 5575-5589. Mertens S, Craxton M and Goedert M. (1996). FEBS Lett, 383, 273-276. Meves A, Stock SN, Beyerle A, Pittelkow MR and Peus D. (2001). Toxicol Lett, 122, 205-214. Minden A, Lin A, Claret FX, Abo A and Karin M. (1995). Cell, 81, 1147-1157. Ming XF, Kaiser M and Moroni C. (1998). EMBO J, 17, 6039-6048. Ming XF, Stoecklin G, Lu M, Looser R and Moroni C. (2001). Mol Cell Biol, 21, 5778-5789. Mitchell P, Petfalski E, Shevchenko A, Mann M and Tollervey D. (1997). Cell, 91, 457-466. Miyamoto T, Ogino N, Yamamoto S and Hayaishi O. (1976). J Biol Chem, 251, 2629-2636. Miyazawa K, Mori A, Miyata H, Akahane M, Ajisawa Y and Okudaira H. (1998). J Biol Chem, 273, 24832-24838. Muda M, Boschert U, Dickinson R, Martinou JC, Martinou I, Camps M, Schlegel W and Arkinstall S. (1996a). J Biol Chem, 271, 4319-4326. Muda M, Theodosiou A, Rodrigues N, Boschert U, Camps M, Gillieron C, Davies K, Ashworth A and Arkinstall S. (1996b). J Biol Chem, 271, 27205-27208. Mukherjee D, Gao M, O'Connor JP, Raijmakers R, Pruijn G, Lutz CS and Wilusz J. (2002). EMBO J, 21, 165-174. Müller-Decker K, Scholz K, Marks F and Furstenberger G. (1995). Mol Carcinog, 12, 31-41. Muzio M, Natoli G, Saccani S, Levrero M and Mantovani A. (1998). J Exp Med, 187, 2097-2101. Narisawa T, Sato M, Tani M, Kudo T, Takahashi T and Goto A. (1981). Cancer Res, 41, 1954-1957. Narko K, Ristimäki A, MacPhee M, Smith E, Haudenschild CC and Hla T. (1997). J Biol Chem, 272, 21455-21460. Nelson C, Rigel D, Smith S, Swanson N and Wolf J. (2004). J Drugs Dermatol, 3, 401-407. O'Banion MK, Winn VD and Young DA. (1992). Proc Natl Acad Sci U S A, 89, 4888-4892. Obata T, Brown GE and Yaffe MB. (2000). Crit Care Med, 28, N67-N77. Onoe Y, Miyaura C, Kaminakayashiki T, Nagai Y, Noguchi K, Chen QR, Seo H, Ohta H, Nozawa S, Kudo I and Suda T. (1996). J Immunol, 156, 758-764. Oshima M, Dinchuk JE, Kargman SL, Oshima H, Hancock B, Kwong E, Trzaskos JM, Evans JF and Taketo MM. (1996). Cell, 87, 803-809. Pages G, Berra E, Milanini J, Levy AP and Pouyssegur J. (2000). J Biol Chem, 275, 26484-26491. Pan CX, Loehrer P, Seitz D, Helft P, Juliar B, Ansari R, Pletcher W, Vinson J, Cheng L and Sweeney C. (2005). Oncology, 69, 63-70. Park GY and Christman JW. (2006). Am J Physiol Lung Cell Mol Physiol, 290, L797-L805. Peng SS, Chen CY, Xu N and Shyu AB. (1998). EMBO J, 17, 3461-3470. Pentland AP and Needleman P. (1986). J Clin Invest, 77, 246-251. Pentland AP, Schoggins JW, Scott GA, Khan KN and Han R. (1999). Carcinogenesis, 20, 1939-1944. Petersen AB, Gniadecki R, Vicanova J, Thorn T and Wulf HC. (2000). J Photochem Photobiol B, 59, 123-131. Peus D, Vasa RA, Beyerle A, Meves A, Krautmacher C and Pittelkow MR. (1999). J Invest Dermatol, 112, 751-756. Piazza GA, Alberts DS, Hixson LJ, Paranka NS, Li H, Finn T, Bogert C, Guillen JM, Brendel K, Gross PH, Sperl G, Ritchie J, Burt RW, Ellsworth L, Ahnen DJ and Pamukcu R. (1997). Cancer Res, 57, 2909-2915. Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ and Davis RJ. (1995). J Biol Chem, 270, 7420-7426. Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B and Davis RJ. (1996). Mol Cell Biol, 16, 1247-1255. Rana A, Gallo K, Godowski P, Hirai S, Ohno S, Zon L, Kyriakis JM and Avruch J. (1996). J Biol Chem, 271, 19025-19028. Ravanat JL, Douki T and Cadet J. (2001). J Photochem Photobiol B, 63, 88-102. Reddy BS, Maruyama H and Kelloff G. (1987). Cancer Res, 47, 5340-5346. Ridley SH, Dean JL, Sarsfield SJ, Brook M, Clark AR and Saklatvala J. (1998). FEBS Lett, 439, 75-80. Ristimaki A, Garfinkel S, Wessendorf J, Maciag T and Hla T. (1994). J Biol Chem, 269, 11769-11775. Ristimaki A, Narko K and Hla T. (1996). Biochem J, 318 ( Pt 1), 325-331. Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, Zamanillo D, Hunt T and Nebreda AR. (1994). Cell, 78, 1027-1037. Rouzer CA and Marnett LJ. (2003). Chem Rev, 103, 2239-2304. Sachs A. (1990). Curr Opin Cell Biol, 2, 1092-1098. Salmeron A, Ahmad TB, Carlile GW, Pappin D, Narsimhan RP and Ley SC. (1996). EMBO J, 15, 817-826. Samet JM, Fasano MB, Fonteh AN and Chilton FH. (1995). J Biol Chem, 270, 8044-8049. Sano H, Kawahito Y, Wilder RL, Hashiramoto A, Mukai S, Asai K, Kimura S, Kato H, Kondo M and Hla T. (1995). Cancer Res, 55, 3785-3789. Schaeffer HJ and Weber MJ. (1999). Mol Cell Biol, 19, 2435-2444. Sengupta S, Jang BC, Wu MT, Paik JH, Furneaux H and Hla T. (2003). J Biol Chem, 278, 25227-25233. Simmons DL, Botting RM and Hla T. (2004). Pharmacol Rev, 56, 387-437. Snipes JA, Kis B, Shelness GS, Hewett JA and Busija DW. (2005). J Pharmacol Exp Ther, 313, 668-676. Souza RF, Shewmake K, Pearson S, Sarosi GA, Jr., Feagins LA, Ramirez RD, Terada LS and Spechler SJ. (2004). Am J Physiol Gastrointest Liver Physiol, 287, G743-G748. Stasinopoulos I, O'Brien DR, Wildes F, Glunde K and Bhujwalla ZM. (2007). Mol Cancer Res, 5, 435-442. Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, Wakabayashi N, Saunders B, Shen Y, Fujimura T, Su LK and Levin B. (2000). N Engl J Med, 342, 1946-1952. Stoecklin G, Ming XF, Looser R and Moroni C. (2000). Mol Cell Biol, 20, 3753-3763. Suarez-Cuervo C, Merrell MA, Watson L, Harris KW, Rosenthal EL, Väänänen HK and Selander KS. (2004). Clin Exp Metastasis, 21, 525-533. Sully G, Dean JL, Wait R, Rawlinson L, Santalucia T, Saklatvala J and Clark AR. (2004). Biochem J, 377, 629-639. Sun Y and Sinicrope FA. (2005). Mol Cancer Ther, 4, 51-59. Sun Y, Tang XM, Half E, Kuo MT and Sinicrope FA. (2002). Cancer Res, 62, 6323-6328. Takekawa M, Posas F and Saito H. (1997). EMBO J, 16, 4973-4982. Tanoue T, Moriguchi T and Nishida E. (1999). J Biol Chem, 274, 19949-19956. Thompson HJ, Briggs S, Paranka NS, Piazza GA, Brendel K, Gross PH, Sperl GJ, Pamukcu R and Ahnen DJ. (1995). J Natl Cancer Inst, 87, 1259-1260. Thun MJ, Henley SJ and Patrono C. (2002). J Natl Cancer Inst, 94, 252-266. Tiano HF, Loftin CD, Akunda J, Lee CA, Spalding J, Sessoms A, Dunson DB, Rogan EG, Morham SG, Smart RC and Langenbach R. (2002). Cancer Res, 62, 3395-3401. Towbin H, Staehelin T and Gordon J. (1979). Proc Natl Acad Sci U S A, 76, 4350-4354. Trifan OC and Hla T. (2003). J Cell Mol Med, 7, 207-222. Trifan OC, Smith RM, Thompson BD and Hla T. (1999). J Biol Chem, 274, 34141-34147. Tsujii M and DuBois RN. (1995). Cell, 83, 493-501. Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M and DuBois RN. (1998). Cell, 93, 705-716. Tyrrell RM. (1996). Bioessays, 18, 139-148. van der Donk WA, Tsai AL and Kulmacz RJ. (2002). Biochemistry, 41, 15451-15458. van Hoof A and Parker R. (1999). Cell, 99, 347-350. van Laethem A, Nys K, van Kelst S, Claerhout S, Ichijo H, Vandenheede JR, Garmyn M and Agostinis P. (2006). Free Radic Biol Med, 41, 1361-1371. Vane JR. (1971). Nat New Biol, 231, 232-235. von Montfort C, Fernau NS, Beier JI, Sies H and Klotz LO. (2006). Free Radic Biol Med, 41, 1478-1487. Walenga RW, Kester M, Coroneos E, Butcher S, Dwivedi R and Statt C. (1996). Prostaglandins, 52, 341-359. Wang W, Furneaux H, Cheng H, Caldwell MC, Hutter D, Liu Y, Holbrook N and Gorospe M. (2000). Mol Cell Biol, 20, 760-769. Wang XS, Diener K, Manthey CL, Wang S, Rosenzweig B, Bray J, Delaney J, Cole CN, Chan-Hui PY, Mantlo N, Lichenstein HS, Zukowski M and Yao Z. (1997). J Biol Chem, 272, 23668-23674. Wesche H, Korherr C, Kracht M, Falk W, Resch K and Martin MU. (1997). J Biol Chem, 272, 7727-7731. Widmann C, Gibson S, Jarpe MB and Johnson GL. (1999). Physiol Rev, 79, 143-180. Williams CS, Tsujii M, Reese J, Dey SK and DuBois RN. (2000). J Clin Invest, 105, 1589-1594. Wilson KP, McCaffrey PG, Hsiao K, Pazhanisamy S, Galullo V, Bemis GW, Fitzgibbon MJ, Caron PR, Murcko MA and Su MS. (1997). Chem Biol, 4, 423-431. Winzen R, Kracht M, Ritter B, Wilhelm A, Chen CY, Shyu AB, Müller M, Gaestel M, Resch K and Holtmann H. (1999). EMBO J, 18, 4969-4980. Xu K and Shu HK. (2007). Cancer Res, 67, 6121-6129. Xu N, Chen CY and Shyu AB. (1997). Mol Cell Biol, 17, 4611-4621. Xu Y, Voorhees JJ and Fisher GJ. (2006). Am J Pathol, 169, 823-830. Yamagata K, Andreasson KI, Kaufmann WE, Barnes CA and Worley PF. (1993). Neuron, 11, 371-386. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E and Matsumoto K. (1995). Science, 270, 2008-2011. Yanase H, Ando H, Horikawa M, Watanabe M, Mori T and Matsuda N. (2001). Pigment Cell Res, 14, 103-109. Yang X, Khosravi-Far R, Chang HY and Baltimore D. (1997). Cell, 89, 1067-1076. Yang X, Wang W, Fan J, Lal A, Yang D, Cheng H and Gorospe M. (2004). J Biol Chem, 279, 49298-49306. Yokoyama C and Tanabe T. (1989). Biochem Biophys Res Commun, 165, 888-894. Young PR, McLaughlin MM, Kumar S, Kassis S, Doyle ML, McNulty D, Gallagher TF, Fisher S, McDonnell PC, Carr SA, Huddleston MJ, Seibel G, Porter TG, Livi GP, Adams JL and Lee JC. (1997). J Biol Chem, 272, 12116-12121. Zhang S, Han J, Sells MA, Chernoff J, Knaus UG, Ulevitch RJ and Bokoch GM. (1995). J Biol Chem, 270, 23934-23936. Zhang Y, Dong Z, Nomura M, Zhong S, Chen N, Bode AM and Dong Z. (2001). J Biol Chem, 276, 20913-20923. | |||||||
| Lizenz: |  Urheberrechtsschutz | |||||||
| Fachbereich / Einrichtung: | Medizinische Fakultät | |||||||
| Dokument erstellt am: | 21.10.2010 | |||||||
| Dateien geändert am: | 14.09.2010 | |||||||
| Promotionsantrag am: | 01.03.2010 | |||||||
| Datum der Promotion: | 02.08.2010 |
