Dokument: Molekulare Grundlagen des embryo-maternalen Dialogs im Reproduktionstrakt der Frau
| Titel: | Molekulare Grundlagen des embryo-maternalen Dialogs im Reproduktionstrakt der Frau | |||||||
| Weiterer Titel: | Molecular basis of the embryo-maternal crosstalk in the female reproductive tract | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=15428 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20100707-100351-8 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | Dipl Biol Baston-Büst, Dunja [Autor] | |||||||
| Dateien: |
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| Beitragende: | PD Dr. Krüssel, Jan [Gutachter] Prof. Dr. Proksch, Peter [Gutachter] | |||||||
| Dewey Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik » 570 Biowissenschaften; Biologie | |||||||
| Beschreibung: | The successful implantation of an embryo depends on a synchronized molecular embryo-maternal dialogue enabling the necessary modifications of maternal tissue as well as
maturation and invasion of the embryo. The studies summarized in this work present cytokines, chemokines, angiogenic factors, proteinases, receptors, co-recectors and inhibitors involved in the complex network of interactions at the embryo-maternal interface. On the one hand, studies focussed on the embryo human and murine: describing the expression of the VEGF system as potent modulators of angiogenesis, the localization of the NRP-1 expression in the cytotrophoblast and the expression of proteinase inhibitors, cystatins, in order to regulate embryonic invasion. On the other hand, investigations focussed on factors expressed and regulating the maternal reproductive tract including fallopian tube and decidua were presented including the expression of the pro-invasive CTSS during secretory phase, the temporal but no spatial different expression of the members of the IL-1 system in the fallopian tube, the increase of NRP-1 expression during proliferative phase endometrium preparing angiogenesis for an implantation, the MAPK signalling cascade for the mediation of CXCL1 expression after contact with the embryo surrogate IL-1ß and the changes of chemokine and angiogenic factors profiling after knock-down of the chemokine co-receptor Sdc-1 in decidua in vitro. All of these findings underline the complexity of molecules involved in the embryo-maternal dialogue enabling a proper implantation and subsequent development of a successful pregnancy. | |||||||
| Lizenz: |  Urheberrechtsschutz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 07.07.2010 | |||||||
| Dateien geändert am: | 24.06.2010 | |||||||
| Promotionsantrag am: | 03.05.2010 | |||||||
| Datum der Promotion: | 02.06.2010 |
