Dokument: Strukturelle und funktionelle Charakterisierung von bakteriellen LOV-Domain Blue-Licht Photorezeptoren
| Titel: | Strukturelle und funktionelle Charakterisierung von bakteriellen LOV-Domain Blue-Licht Photorezeptoren | |||||||
| Weiterer Titel: | Structural and Functional Characterization of Bacterial LOV Domain-containing Blue-Light Photoreceptors | |||||||
| URL für Lesezeichen: | https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=15049 | |||||||
| URN (NBN): | urn:nbn:de:hbz:061-20100506-133431-0 | |||||||
| Kollektion: | Dissertationen | |||||||
| Sprache: | Englisch | |||||||
| Dokumententyp: | Wissenschaftliche Abschlussarbeiten » Dissertation | |||||||
| Medientyp: | Text | |||||||
| Autor: | Dr. Cao, Zhen [Autor] | |||||||
| Dateien: |
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| Dewey Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik » 540 Chemie | |||||||
| Beschreibung: | Summary
In the late 19th century, Charles Darwin and his son had noticed in several plant species an interesting feature: phototropism, a light dependent directional growth towards the light source. However, the responsible photoreceptor protein, phototropin with a conserved light, oxygen and voltage (LOV) domain, could only be identified until the end of 20th century. Later, it has been discovered that this conserved LOV signaling module is not restricted in plant; it is actually widely distributed in all three kingdoms of life with the only exception of animals. YtvA from Bacillus subtilis, a 261 amino acid protein was the first bacterial LOV-domain containing protein that has been proven to undergo a phototropin-like blue light induced photocycles. Since then, the knowledge about prokaryotic LOV domain-containing proteins was rapidly growing and many other bacterial LOV proteins with quite diversified downstream effector domains have also been characterized. This present thesis will try to broaden our knowledge about the molecular basis of signal transmission within several bacterial LOV domain-containing proteins. The connections between the structure of these proteins and their functions will also be part of this work. The study of YtvA from Bacillus subtilis has been continued in this present work, besides its recently discovered NTP-binding function, the inter-domain interaction of YtvA and the detailed communicating pathway have also been extensively investigated. A possible common connecting interface for the signal transmission in this protein was examined. The structure of another LOV domain from Bacillus amyloliquefaciens also adds further information on LOV domain dimerization and presents a novel type dimmer formation. Some other bacterial LOV-containing proteins with different effector domains have also been characterized for the first time, including a blue light regulated two-component signaling protein from Pseudomonas syringae and a LOV-containing GGDEF/EAL protein from Synechococcus, both of the two have combined the blue light sensing LOV domain to some well-established signaling modules that are found widely distributed in many bacterial species. | |||||||
| Lizenz: |  Urheberrechtsschutz | |||||||
| Fachbereich / Einrichtung: | Mathematisch- Naturwissenschaftliche Fakultät | |||||||
| Dokument erstellt am: | 06.05.2010 | |||||||
| Dateien geändert am: | 06.05.2010 | |||||||
| Promotionsantrag am: | 15.03.2005 | |||||||
| Datum der Promotion: | 30.04.2010 |
